Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 167, Issue -, Pages 659-666Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.11.214
Keywords
Glycol chitosan/oxidized hyaluronic acid hydrogel film; Dual drug delivery; Ocular drug delivery
Funding
- Zhejiang Provincial Natural Science Foundation of China [LR18H300002, LQ20H180006, LQ20H18007, LY21H180004, LQ21H180011]
- National Natural Science Foundation of China [31671022, 81971732]
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In this study, a glycol chitosan/oxidized hyaluronic acid hydrogel film for dual ophthalmic drug delivery was fabricated successfully. The hydrogel films exhibited a stepwise release of levofloxacin and dexamethasone, demonstrating potent antibacterial and anti-inflammatory activities.
In the present study, we fabricated a glycol chitosan/oxidized hyaluronic acid hydrogel film with promising potential for the dual ophthalmic delivery of dexamethasone (Dex) and levofloxacin (Lev). Utilizing different oxidation degrees of oxidized hyaluronic acid (OHA), several blank hydrogel films and Lev-loaded hydrogel films were successfully fabricated. With an increase in the oxidation degree of OHA, the swelling ratio of the hydrogel films decreased accordingly. The hydrogel films displayed a stepwise release of Lev and Dex, with Lev rapidly released from the hydrogel film, followed by a sustained release of Dex. Lev-loaded hydrogel films revealed a potent capacity to inhibit bacterial growth in different bacterial strains. In lipopolysaccharide-activated RAW264.7 macrophages, the formulated hydrogel films displayed potent in vitro anti-inflammatory activity by significantly various inflammatory cytokines. Overall, the fabricated hydrogel film acting as a dual drug delivery system might be a promising vehicle for the treatment of postoperative endophthalmitis. (C) 2020 Elsevier B.V. All rights reserved.
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