SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus

Sirt3 deficiency impairs neurovascular recovery in ischemic stroke

(2018) Xiao Yang et al.   CNS Neuroscience & Therapeutics

SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/β-catenin pathway

(2018) Rong Li et al.   EXPERIMENTAL CELL RESEARCH

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

(2018) José Teixeira et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Beneficial Effects of Flavonoids Against Parkinson's Disease

(2018) Un Ju Jung et al.   JOURNAL OF MEDICINAL FOOD

Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress

(2018) Jia Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nitric Oxide and Mitochondrial Function in Neurological Diseases

(2018) Mehdi Ghasemi et al.   NEUROSCIENCE

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway

(2018) Sindhu Ramesh et al.   PLoS One

Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions

(2018) Yufei Song et al.   Scientific Reports

Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition

(2018) Fernando Bartolome et al.   Alzheimers Research & Therapy

SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway

(2018) Meng Zhang et al.   Aging and Disease

Mitochondrial genome variability: the effect on cellular functional activity

(2018) Aleksandrina Volobueva et al.   Therapeutics and Clinical Risk Management

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

(2018) Yachun Han et al.   Redox Biology

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress

(2017) Han Shi et al.   HUMAN MOLECULAR GENETICS

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

(2017) Javier Traba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial SIRT3 and neurodegenerative brain disorders

(2017) Anamika et al.   JOURNAL OF CHEMICAL NEUROANATOMY

MicroRNA-27a-3p suppression of peroxisome proliferator-activated receptor-γ contributes to cognitive impairments resulting from sevoflurane treatment

(2017) Xiang Lv et al.   JOURNAL OF NEUROCHEMISTRY

Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity

(2017) Wei-Xing Zhao et al.   Journal of Neuroinflammation

Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity

(2017) Lingling Sun et al.   Journal of Neuroinflammation

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Cognitive Impairment and Overall Survival in Frail Surgical Patients

(2017) Salima S. Makhani et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

SIRT3 and mitochondrial metabolism in neurodegenerative diseases

(2017) Illari Salvatori et al.   NEUROCHEMISTRY INTERNATIONAL

SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway

(2017) De-Qi Jiang et al.   Frontiers in Cellular Neuroscience

Resveratrol Attenuates Neurodegeneration and Improves Neurological Outcomes after Intracerebral Hemorrhage in Mice

(2017) Frederick Bonsack et al.   Frontiers in Cellular Neuroscience

Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats

(2017) Jing Wu et al.   Frontiers in Cellular Neuroscience

SIRT3-KLF15 signaling ameliorates kidney injury induced by hypertension

(2017) Na Li et al.   Oncotarget

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

(2017) Vinodkumar B. Pillai et al.   Oncotarget

Honokiol suppresses formyl peptide-induced human neutrophil activation by blocking formyl peptide receptor 1

(2017) Fu-Chao Liu et al.   Scientific Reports

Comparison of Sirtuin 3 Levels in ALS and Huntington’s Disease—Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models

(2017) Eva Buck et al.   Frontiers in Molecular Neuroscience

Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells

(2017) Lian-Xiang Luo et al.   Frontiers in Pharmacology

Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction

(2016) Jhy-Shrian Huang et al.   BMC CANCER

Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection

(2016) Zhenhua Zeng et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications

(2016) Yi Lu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

Surgery-Induced Hippocampal Angiotensin II Elevation Causes Blood-Brain Barrier Disruption via MMP/TIMP in Aged Rats

(2016) Zhengqian Li et al.   Frontiers in Cellular Neuroscience

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

(2016) Kaname Akamata et al.   Oncotarget

Altered Mitochondrial Dynamics Contributes to Propofol-induced Cell Death in Human Stem Cell–derived Neurons

(2015) Danielle M. Twaroski et al.   ANESTHESIOLOGY

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

(2015) Huifeng Pi et al.   Autophagy

Honokiol improves learning and memory impairments induced by scopolamine in mice

(2015) Yan-Fang Xian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

4′-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation

(2015) Andrea Chicca et al.   Journal of Neuroinflammation

Surgery plus anesthesia induces loss of attention in mice

(2015) Quan Ren et al.   Frontiers in Cellular Neuroscience

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Disruption of Hippocampal Neuregulin 1–ErbB4 Signaling Contributes to the Hippocampus-dependent Cognitive Impairment Induced by Isoflurane in Aged Mice

(2014) Xiao-Min Li et al.   ANESTHESIOLOGY

MnTM-4-PyP Modulates Endogenous Antioxidant Responses and Protects Primary Cortical Neurons against Oxidative Stress

(2014) Kuo-Yuan Cheng et al.   CNS Neuroscience & Therapeutics

Posttreatment with propofol attenuates lipopolysaccharide-induced up-regulation of inflammatory molecules in primary microglia

(2014) Mian Peng et al.   INFLAMMATION RESEARCH

Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis

(2014) Dimiter B. Avtanski et al.   Molecular Oncology

Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline

(2013) Niccolò Terrando et al.   FASEB JOURNAL

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells

(2013) Dennis Y Chuang et al.   Journal of Neuroinflammation

Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABAAreceptor in mice

(2012) Wei-Min Qu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroprotection by Manganese Superoxide Dismutase (MnSOD) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke

(2012) Hai-Feng Huang et al.   CNS Neuroscience & Therapeutics

Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

(2011) Pratibha V Nerurkar et al.   Journal of Neuroinflammation

Effect of honokiol on activity of GAD65 and GAD67 in the cortex and hippocampus of mice

(2011) Tien-Hsiung Ku et al.   PHYTOMEDICINE

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

(2010) N. Terrando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA