Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

(2012) Mitsumasa Kurita et al.   NATURE NEUROSCIENCE

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin

(2012) R. L. Carhart-Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based drug screening for G-protein-coupled receptors

(2012) Brian K. Shoichet et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

Compensatory redistribution of neuroligins and N-cadherin following deletion of synaptic β1-integrin

(2011) Steven Mortillo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

(2011) Eneko Urizar et al.   Nature Chemical Biology

Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists

(2011) José L. Moreno et al.   NEUROSCIENCE LETTERS

Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: Antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients

(2010) Jesús A. García-Sevilla et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling

(2010) Ana C Magalhaes et al.   NATURE NEUROSCIENCE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

A Flow Cytometry-Based FRET Assay to Identify and Analyse Protein-Protein Interactions in Living Cells

(2010) Carina Banning et al.   PLoS One

Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

(2010) J. A. Hern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

(2009) Graeme Milligan   BRITISH JOURNAL OF PHARMACOLOGY

Functional crosstalk between GPCRs: with or without oligomerization

(2009) Laurent Prezeau et al.   CURRENT OPINION IN PHARMACOLOGY

Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer

(2009) Juan José Fung et al.   EMBO JOURNAL

Instability of a Class A G Protein-Coupled Receptor Oligomer Interface

(2009) J. M. Fonseca et al.   MOLECULAR PHARMACOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices

(2009) George K. Aghajanian   PSYCHOPHARMACOLOGY

Psychedelics and schizophrenia

(2009) Javier González-Maeso et al.   TRENDS IN NEUROSCIENCES

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways

(2009) Xavier Rovira et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Hallucinogen DOI Reduces Low-Frequency Oscillations in Rat Prefrontal Cortex: Reversal by Antipsychotic Drugs

(2008) Pau Celada et al.   BIOLOGICAL PSYCHIATRY

Dopamine D2 receptors form higher order oligomers at physiological expression levels

(2008) Wen Guo et al.   EMBO JOURNAL

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Detection of heteromerization of more than two proteins by sequential BRET-FRET

(2008) Paulina Carriba et al.   NATURE METHODS

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

(2008) Damien Maurel et al.   NATURE METHODS

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE