Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies

Antioxidant Therapy Does Not Ameliorate Oxidative Stress and Inflammation in Patients With End-Stage Renal Disease

(2015) Mohammad Kamgar et al.   JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION

Hypotensive effect of atorvastatin is not related to changes in inflammation and oxidative stress

(2014) Agnieszka M. Kuklińska et al.   Pharmacological Reports

Tetrahydrobiopterin and hypertension: more than an emigrating story

(2011) Judy Y. Lin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Racial Differences in Oxidative Stress and Inflammation: In Vitro and In Vivo

(2011) Deborah L. Feairheller et al.   CTS-Clinical and Translational Science

Antihypertensive effects exerted by enalapril in mild to moderate hypertension are not associated with changes in the circulating levels of nitric oxide-related markers

(2011) Pamela S. Silva et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

NADPH oxidase inhibitors: a patent review

(2011) Jung-Ae Kim et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

T Regulatory Lymphocytes Prevent Angiotensin II–Induced Hypertension and Vascular Injury

(2011) Tlili Barhoumi et al.   HYPERTENSION

Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR

(2011) Ana M. Briones et al.   Journal of the American Society of Hypertension

Antioxidants in Hypertension and Cardiovascular Disease

(2011) E. L. Schiffrin   MOLECULAR INTERVENTIONS

NOX Isoforms and Reactive Oxygen Species in Vascular Health

(2011) R. M. Touyz et al.   MOLECULAR INTERVENTIONS

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Vascular Structure and Oxidative Stress in Salt-Loaded Spontaneously Hypertensive Rats: Effects of Losartan and Atenolol

(2010) E. M. V. de Cavanagh et al.   AMERICAN JOURNAL OF HYPERTENSION

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

(2010) Anna E. Dikalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats

(2010) Kyu-Tae Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Impact of elevated dietary sodium intake on NAD(P)H oxidase and SOD in the cortex and medulla of the rat kidney

(2010) Edward J. Johns et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

(2010) Andreas Daiber   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

NADPH oxidase 4 is an oncoprotein localized to mitochondria

(2010) Kelly A. Graham et al.   CANCER BIOLOGY & THERAPY

Inhibition and Genetic Ablation of the B7/CD28 T-Cell Costimulation Axis Prevents Experimental Hypertension

(2010) Antony Vinh et al.   CIRCULATION

Nox Activator 1

(2010) Xi-Lin Niu et al.   CIRCULATION

Role of NADPH Oxidase in Endothelial Ischemia/Reperfusion Injury in Humans

(2010) Stavros P. Loukogeorgakis et al.   CIRCULATION

Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells

(2010) Augusto C. Montezano et al.   CIRCULATION RESEARCH

Upregulation of Nox4 by TGFβ1 Oxidizes SERCA and Inhibits NO in Arterial Smooth Muscle of the Prediabetic Zucker Rat

(2010) XiaoYong Tong et al.   CIRCULATION RESEARCH

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

(2010) Augusto C. Montezano et al.   CLINICAL SCIENCE

T lymphocytes: a role in hypertension?

(2010) Ernesto L Schiffrin   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Role of the adaptive immune system in hypertension

(2010) David G Harrison et al.   CURRENT OPINION IN PHARMACOLOGY

Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation

(2010) Davide Gianni et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Safety of sapropterin dihydrochloride (6r–bh4) in patients with pulmonary hypertension

(2010) Ivan M. Robbins et al.   EXPERIMENTAL LUNG RESEARCH

Reactive oxygen species and vascular biology: implications in human hypertension

(2010) Rhian M Touyz et al.   HYPERTENSION RESEARCH

Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters

(2010) Douglas Greig et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice

(2010) Nicolas Godin et al.   KIDNEY INTERNATIONAL

Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial

(2010) David R McCance et al.   LANCET

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

(2010) R.-F. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Global Noncommunicable Diseases — Where Worlds Meet

(2010) K.M. Venkat Narayan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vitamins C and E to Prevent Complications of Pregnancy-Associated Hypertension

(2010) James M. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of NOXO1 Activity through Reversible Interactions with p22phox and NOXA1

(2010) Sujit Dutta et al.   PLoS One

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction

(2009) Sachin A. Gupte et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nox5 and the Regulation of Cellular Function

(2009) David J.R. Fulton   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase 1 Deficiency Alters Caveolin Phosphorylation and Angiotensin II–Receptor Localization in Vascular Smooth Muscle

(2009) Olivier Basset et al.   ANTIOXIDANTS & REDOX SIGNALING

Cross-Talk Between Mitochondria and NADPH Oxidase: Effects of Mild Mitochondrial Dysfunction on Angiotensin II-Mediated Increase in Nox Isoform Expression and Activity in Vascular Smooth Muscle Cells

(2009) João Wosniak et al.   ANTIOXIDANTS & REDOX SIGNALING

Receptor Activation of NADPH Oxidases

(2009) Andreas Petry et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: Effects of nitrosothiol exposure

(2009) Denise C. Fernandes et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation

(2009) Moo Yeol Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

JAK/STAT Signaling Pathway Regulates Nox1 and Nox4-Based NADPH Oxidase in Human Aortic Smooth Muscle Cells

(2009) Adrian Manea et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hereditary Deficiency of gp91 phox Is Associated With Enhanced Arterial Dilatation

(2009) Francesco Violi et al.   CIRCULATION

Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes

(2009) Alan R. Collins et al.   CIRCULATION RESEARCH

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers

(2009) Daniela Giustarini et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

The redox state of glutathione regulates the hypoxic induction of HIF-1

(2009) Masamichi Tajima et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Crosstalk signaling between mitochondrial Ca2+ and ROS

(2009) Robert et al.   Frontiers in Bioscience-Landmark

Losartan Metabolite EXP3179 Blocks NADPH Oxidase-Mediated Superoxide Production by Inhibiting Protein Kinase C

(2009) Ana Fortuño et al.   HYPERTENSION

Angiotensin II, Oxidant Signaling, and Hypertension

(2009) Robin L. Davisson et al.   HYPERTENSION

Induction of Hypertension and Peripheral Inflammation by Reduction of Extracellular Superoxide Dismutase in the Central Nervous System

(2009) Heinrich E. Lob et al.   HYPERTENSION

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low-sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans

(2009) Y Al-Solaiman et al.   JOURNAL OF HUMAN HYPERTENSION

Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats

(2008) Emilie C. Viel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-β1 and insulin-like growth factor binding protein-3

(2008) Saleh Ismail et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Protein Tyrosine Phosphorylation and Protein Tyrosine Nitration in Redox Signaling

(2008) Hugo P. Monteiro et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes

(2008) Katrin Schröder et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of reactive oxygen species in brainstem in neural mechanisms of hypertension

(2008) Yoshitaka Hirooka   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Activation of NADPH oxidase 1 in tumour colon epithelial cells

(2008) Yukio Nisimoto et al.   BIOCHEMICAL JOURNAL

Redox-Sensitive Signaling by Angiotensin II Involves Oxidative Inactivation and Blunted Phosphorylation of Protein Tyrosine Phosphatase SHP-2 in Vascular Smooth Muscle Cells From SHR

(2008) Fatiha Tabet et al.   CIRCULATION RESEARCH

GPCR signalling in hypertension: role of GRKs

(2008) David M. Harris et al.   CLINICAL SCIENCE

Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension

(2008) Ramón Rodrigo et al.   CLINICAL SCIENCE

Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome

(2008) D. Walter Wray et al.   CLINICAL SCIENCE

Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase

(2008) Tomoko Nishino et al.   FEBS Journal

Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells

(2008) Desmond B. Jay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCɛ signaling axis in pulmonary artery smooth muscle cells

(2008) R RATHORE et al.   FREE RADICAL BIOLOGY AND MEDICINE

Renal Redox-Sensitive Signaling, but Not Blood Pressure, Is Attenuated by Nox1 Knockout in Angiotensin II–Dependent Chronic Hypertension

(2008) Alvaro Yogi et al.   HYPERTENSION

Lipid Rafts Keep NADPH Oxidase in the Inactive State in Human Renal Proximal Tubule Cells

(2008) Weixing Han et al.   HYPERTENSION

Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease

(2008) Tomasz J. Guzik et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade

(2008) Shan Chen et al.   KIDNEY INTERNATIONAL

Endothelin-1 and F2-isoprostane relate to and predict renal dysfunction in hypertensive patients

(2008) S. Cottone et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension

(2008) B. Klanke et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Excess Salt Causes Cerebral Neuronal Apoptosis and Inflammation in Stroke-Prone Hypertensive Rats Through Angiotensin II-Induced NADPH Oxidase Activation

(2008) Eiichiro Yamamoto et al.   STROKE

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH

Mechanisms underlying developmental programming of elevated blood pressure and vascular dysfunction: evidence from human studies and experimental animal models

(2007) Anne Monique Nuyt   CLINICAL SCIENCE

The Interaction Between Coronary Endothelial Dysfunction, Local Oxidative Stress, and Endogenous Nitric Oxide in Humans

(2007) Shahar Lavi et al.   HYPERTENSION