E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation

Innate immune responses to DNA viruses

(2013) Ying Nie et al.   Protein & Cell

Linear Ubiquitination of NEMO Brakes the Antiviral Response

(2012) Yan-Yi Wang et al.   Cell Host & Microbe

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

(2011) Yukio Nakamura et al.   Nature Communications

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid

(2010) Weiguo Zou et al.   NATURE CELL BIOLOGY

WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells

(2009) Huiming Xu et al.   CELL RESEARCH

The HECT-Type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T-Cell Death by Catalyzing EGR2 Ubiquitination

(2009) A. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY