Epigenomics and Interindividual Differences in Drug Response

Chemotherapeutic Drug-Induced ABCG2 Promoter Demethylation as a Novel Mechanism of Acquired Multidrug Resistance

(2015) Eran E. Bram et al.   NEOPLASIA

Clinical Significance of CDH13 Promoter Methylation in Serum Samples from Patients with Bladder Transitional Cell Carcinoma

(2013) YL Lin et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Epigenetic markers of prostate cancer in plasma circulating DNA

(2012) Rene Cortese et al.   HUMAN MOLECULAR GENETICS

Serum DNA methylation for monitoring response to neoadjuvant chemotherapy in breast cancer patients

(2012) Ayelet Avraham et al.   INTERNATIONAL JOURNAL OF CANCER

Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1

(2012) Oliver Kaut et al.   NEUROGENETICS

5-Hydroxymethylcytosine, the Sixth Base of the Genome

(2011) Martin Münzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibitors of histone demethylases

(2011) Brian Lohse et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

Detection of TFPI2 methylation in the serum of colorectal cancer patients

(2011) Kenji Hibi et al.   CANCER LETTERS

Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression

(2011) F. Aguilo et al.   CANCER RESEARCH

Mbd3/NURD Complex Regulates Expression of 5-Hydroxymethylcytosine Marked Genes in Embryonic Stem Cells

(2011) Ozlem Yildirim et al.   CELL

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

(2011) Kian Peng Koh et al.   Cell Stem Cell

An Epigenetic Marker Panel for Detection of Lung Cancer Using Cell-Free Serum DNA

(2011) S. Begum et al.   CLINICAL CANCER RESEARCH

Perspectives on Epigenetics and Its Relevance to Adverse Drug Reactions

(2011) M Kacevska et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Epigenetic-Based Therapies in Cancer

(2011) Sang-Hyun Song et al.   DRUGS

Alterations of microRNAs in Cisplatin-resistant Human Non-small Cell Lung Cancer Cells (A549/DDP)

(2011) Qi Wang et al.   EXPERIMENTAL LUNG RESEARCH

Xist regulation and function eXplored

(2011) Daphne B. Pontier et al.   HUMAN GENETICS

DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung

(2011) Xavier Tekpli et al.   INTERNATIONAL JOURNAL OF CANCER

Histone deacetylase 1 is required for Carbamazepine-induced CYP3A4 expression

(2011) Yin Wu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2

(2011) Wei Zhu et al.   MEDICAL ONCOLOGY

An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells

(2011) Yusuke Yamamoto et al.   Molecular Cancer

Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

(2011) Yufei Xu et al.   MOLECULAR CELL

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

MicroRNAs in body fluids—the mix of hormones and biomarkers

(2011) Maria Angelica Cortez et al.   Nature Reviews Clinical Oncology

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Global Analysis of DNA Methylation by Methyl-Capture Sequencing Reveals Epigenetic Control of Cisplatin Resistance in Ovarian Cancer Cell

(2011) Wei Yu et al.   PLoS One

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA pharmacogenomics: Post-transcriptional regulation of drug response

(2011) Jakob Lewin Rukov et al.   TRENDS IN MOLECULAR MEDICINE

Detection of Slit2 promoter hypermethylation in tissue and serum samples from breast cancer patients

(2011) Ga-Eon Kim et al.   VIRCHOWS ARCHIV

Interplay between microRNAs and the epigenetic machinery: An intricate network

(2010) Marilena V. Iorio et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Identification of Hypermethylated Genes Associated with Cisplatin Resistance in Human Cancers

(2010) Xiaofei Chang et al.   CANCER RESEARCH

MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

(2010) Elisa Giovannetti et al.   CANCER RESEARCH

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS

(2010) Eric Pasmant et al.   FASEB JOURNAL

Methylation patterns in cell-free plasma DNA reflect removal of the primary tumor and drug treatment of breast cancer patients

(2010) Thomas E. Liggett et al.   INTERNATIONAL JOURNAL OF CANCER

DNA Methylation Patterns of Ulcer-Healing Genes Associated with the Normal Gastric Mucosa of Gastric Cancers

(2010) Seung-Jin Hong et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Epigenetic Regulation in Estrogen Receptor Positive Breast Cancer—Role in Treatment Response

(2010) Thushangi N. Pathiraja et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

(2010) Yanqi Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

(2010) Myunggon Ko et al.   NATURE

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Identification of preferential target sites for human DNA methyltransferases

(2010) Si Ho Choi et al.   NUCLEIC ACIDS RESEARCH

Identification of MicroRNA-21 as a Biomarker for Chemoresistance and Clinical Outcome Following Adjuvant Therapy in Resectable Pancreatic Cancer

(2010) Jin-Hyeok Hwang et al.   PLoS One

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Pharmacogenomic biomarkers: new tools in current and future drug therapy

(2010) Sarah C. Sim et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis

(2009) Motoko Unoki et al.   BIOCHEMICAL PHARMACOLOGY

Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes

(2009) S. Hauswald et al.   CLINICAL CANCER RESEARCH

Histone acetyl transferases as emerging drug targets

(2009) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

(2009) Elmar W. Tobi et al.   HUMAN MOLECULAR GENETICS

Detection of circulating fetal nucleic acids: a review of methods and applications

(2009) E C W Hung et al.   JOURNAL OF CLINICAL PATHOLOGY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells

(2009) Peter G. Hawkins et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of Chemotherapeutic Drug Resistance in Cancer Therapy—A Quick Review

(2009) Fu-Shing Liu   Taiwanese Journal of Obstetrics & Gynecology

Histone modifying enzymes: Structures, mechanisms, and specificities

(2008) Ronen Marmorstein et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Identification of CDK10 as an Important Determinant of Resistance to Endocrine Therapy for Breast Cancer

(2008) Elizabeth Iorns et al.   CANCER CELL

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

(2008) S. Kuramochi-Miyagawa et al.   GENES & DEVELOPMENT

Down-regulation of Micro-RNA-1 (miR-1) in Lung Cancer

(2008) Mohd W. Nasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY