Sensitivity of Intravenous and Oral Alfentanil and Pupillary Miosis as Minimal and Noninvasive Probes for Hepatic and First-Pass CYP3A Induction

Concurrent Assessment of Hepatic and Intestinal Cytochrome P450 3A Activities Using Deuterated Alfentanil

(2011) E D Kharasch et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

(2010) Antonia H. Tolson et al.   ADVANCED DRUG DELIVERY REVIEWS

Selection of Alternative CYP3A4 Probe Substrates for Clinical Drug Interaction Studies Using In Vitro Data and In Vivo Simulation

(2010) R. S. Foti et al.   DRUG METABOLISM AND DISPOSITION

Using drug probes to monitor hepatic drug metabolism in critically ill patients: midazolam, a flawed but useful tool for clinical investigation of CYP3A activity?

(2010) Chris Kirwan et al.   Expert Opinion on Drug Metabolism & Toxicology

Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport

(2009) Evan D. Kharasch et al.   ANESTHESIOLOGY

Towards a Quantitative Framework for the Prediction of DDIs Arising from Cytochrome P450 Induction

(2009) L. Almond et al.   CURRENT DRUG METABOLISM

Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

(2009) Evan D. Kharasch et al.   DRUG AND ALCOHOL DEPENDENCE

In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective

(2009) V. Chu et al.   DRUG METABOLISM AND DISPOSITION

Pregnane X Receptor (PXR) Regulates P-Glycoprotein at the Blood-Brain Barrier: Functional Similarities between Pig and Human PXR

(2009) M. Ott et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Scientific and Regulatory Perspectives on Metabolizing Enzyme−Transporter Interplay and Its Role in Drug Interactions: Challenges in Predicting Drug Interactions†

(2009) Lei Zhang et al.   MOLECULAR PHARMACEUTICS

Assessment of Blood–Brain Barrier Permeability Using the In Situ Mouse Brain Perfusion Technique

(2009) Rong Zhao et al.   PHARMACEUTICAL RESEARCH

Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4β-Hydroxycholesterol

(2008) KP Kanebratt et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: The role of complex biophase distribution kinetics

(2008) Dorien Groenendaal et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Limitations of Using a Single Postdose Midazolam Concentration to Predict CYP3A-Mediated Drug Interactions

(2008) Scott R. Penzak et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

(2008) Jason A. Zastre et al.   JOURNAL OF NEUROSCIENCE RESEARCH