Article
Ophthalmology
Carlo Bellucci, Andrea Perrella, Maurizio Rossi, Annalaura Papapicco, Federico Spadini, Salvatore Antonio Tedesco, Stefano Gandolfi, Paolo Mora
Summary: This study evaluated the pupillary characteristics and response to light and drugs in eyes with posterior chamber (PC) placement of iris-claw intraocular lens (IC-IOL). The results showed that the IC-IOL group had a smaller pupil diameter under scotopic conditions and after pharmacological mydriasis, and a larger pupil diameter after pharmacological miosis compared to the control group. This study provides additional observations on drug-induced pupil motility in eyes with PC placement of IC-IOLs.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Joji Kotani, Hiroyuki Nakao, Isamu Yamada, Atsushi Miyawaki, Naomi Mambo, Yuko Ono
Summary: A new automatic mobile pupilometer has been developed to measure both the pupil diameter and light reflex of both pupils simultaneously, providing an important tool for clinical evaluation of patients' pupil conditions.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Weihua Ding, Zhichuan Chen, Yayun Gu, Zhengru Chen, Yanqiong Zheng, Fei Sun
Summary: The use of gold nanorods for mild testicular hyperthermia can achieve controllable male contraception, while a noninvasive targeting approach using iron oxide nanoparticles shows promise for future application. The magnetic properties and particle size of IONPs significantly affect their targeting ability in the testes.
Article
Pharmacology & Pharmacy
Kine Eide Kvitne, Ole Martin Drevland, Nora Haugli, Eline Skadberg, Hasse Khiabani Zare, Anders Asberg, Ida Robertsen
Summary: This study describes the intraindividual variability in absolute bioavailability and clearance of midazolam in healthy individuals. The results show that while the average intraindividual variability is low to moderate, there is considerable variability in the absolute bioavailability in a relatively large proportion of individuals.
CLINICAL PHARMACOKINETICS
(2023)
Article
Pharmacology & Pharmacy
Sara Shum, Danny D. Shen, Nina Isoherranen
Summary: Fentanyl, an opioid analgesic used to treat obstetrical pain, can cross the placental barrier and potentially be abused by pregnant women. A maternal-fetal physiologically based pharmacokinetic (mf-PBPK) model was developed to predict maternal and fetal exposure to fentanyl, demonstrating its utility in assessing drug impact on pregnant women and fetuses. The study establishes a modeling framework for predicting fentanyl exposure, which can be extended to assess fetal exposures to other drugs of abuse.
DRUG METABOLISM AND DISPOSITION
(2021)
Article
Biochemistry & Molecular Biology
Kaiwei Yang, Hailong Hu, Junlong Wu, Huina Wang, Zhaoxia Guo, Wei Yu, Lin Yao, Feng Ding, Tao Zhou, Wang Wang, Yunkai Wang, Lei Liu, Jing Guo, Shuaipeng Zhu, Xinhao Zhang, Shanbo Cao, Feng Lou, Yuanjie Niu, Dingwei Ye, Zhisong He
Summary: Current methods for early detection and MRD monitoring of urothelial carcinoma (UC) are invasive or suboptimal in sensitivity. A new workflow called utLIFE, based on UC-specific mutations and large copy number variations, can detect UC with high sensitivity and specificity. It has been validated in bladder cancer and upper tract urothelial carcinoma cohorts, showing improved sensitivity compared to cytology and fluorescence in situ hybridization (FISH).
Article
Engineering, Biomedical
Sarathkumar Loganathan, Soundarapandian Santhanakrishnan, Ravi Bathe, Muthukumaraswamy Arunachalam
Summary: This study proposed a method using nondestructive techniques to predict laser ablation profiles for high precision laser surgery, establishing a correlation between chemical composition of teeth and ablation parameters. By utilizing FTIR and Raman probes, the study successfully predicts laser ablation behavior in different materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Clinical Neurology
Christopher Blair, Leon Edwards, Cecilia Cappelen-Smith, Dennis Cordato, Andrew Cheung, Jason Wenderoth, Alex McQuinn, Nathan W. Manning
Summary: The study showed that patients who achieved reperfusion with a single pass during endovascular thrombectomy had better outcomes at 90 days compared to those who required multiple passes. Bridging intravenous thrombolysis did not provide additional benefit in first-pass patients but reduced the risk of disability and mortality in multiple-pass patients.
CEREBROVASCULAR DISEASES
(2021)
Article
Biochemical Research Methods
Lu-Ning Sun, Ye Shen, Yu-Qing Yang, Xiang-Long Chen, Feng-Ru Huang, Dun-Jian Wang, Ye Zhang, Da-Wei Wang, Yong-Qing Wang
Summary: A liquid chromatography with tandem mass spectrometry method was developed and validated for simultaneous quantification of cortisol and 6 beta-hydroxycortisol in plasma. The method showed good precision, accuracy, and stability under storage and processing conditions.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2023)
Article
Anesthesiology
Pyoyoon Kang, Sang-Hwan Ji, Jung-bin Park, Young-Eun Jang, Eun-Hee Kim, Ji-Hyun Lee, Jin-Tae Kim, Hee-Soo Kim
Summary: The effects of anesthetic agents on the Neurological Pupil index differ in pediatric patients. Sevoflurane leads to significantly lower Neurological Pupil index values, while propofol also reduces the index at all time points. Additionally, the effects on constriction velocity and dilation velocity differ between the two anesthetic agents.
PEDIATRIC ANESTHESIA
(2023)
Article
Rheumatology
Matthew G. G. Alben, Neil Gambhir, Dhruv Shankar, Dan Gordon, Joseph D. D. Zuckerman, Mandeep S. S. Virk
Summary: This study aims to calculate the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient acceptable symptom state (PASS) of Patient-Reported Outcomes Measurement Information System (PROMIS) in patients with nonoperative treatment for idiopathic adhesive capsulitis (IAC) using anchor-based and distribution-based methods.
CLINICAL RHEUMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Baohua Xu, Ting Yang, Jianxing Zhou, You Zheng, Jingting Wang, Qingxia Liu, Dandan Li, Yifan Zhang, Maobai Liu, Xuemei Wu
Summary: This study developed a population pharmacokinetics model for saliva and plasma, and evaluated its predictive performance in estimating the area under the concentration-time curve at steady state (AUC(ss)) based on saliva samples. The results showed that saliva can be used as an alternative matrix to plasma in therapeutic drug monitoring (TDM) of busulfan (BU). Bayesian maximum a posteriori (MAP) optimization was used to predict AUC(ss) from saliva concentration, which can be used for personalized dosing of BU.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2023)
Article
Hematology
Ahmad A. Alharbi, Abdullah A. Alharbi, Dhafer Salem Bashen, Tarek Owaidah
Summary: This study evaluated the safety and efficacy of IV-FCM in patients with IDA not responding to oral therapy, showing significant improvements in hemoglobin concentration and MCV with a low reversible risk of hyperferritinemia following multiple doses.
JOURNAL OF BLOOD MEDICINE
(2022)