Viral vector-mediated gene transfer for CNS disease

Gene Therapy for Lysosomal Storage Diseases (LSDs) in Large Animal Models

(2013) M. Haskins   ILAR JOURNAL

Preclinical Safety Validation of a Stabilized Viral Vector Direct Injection Approach to the Cervical Spinal Cord

(2009) Thais Federici et al.   CTS-Clinical and Translational Science

Adenoviral virotherapy for malignant brain tumors

(2009) Suvobroto Nandi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A human trial of HSV-mediated gene transfer for the treatment of chronic pain

(2009) D Wolfe et al.   GENE THERAPY

Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice

(2009) D M McCarty et al.   GENE THERAPY

Development of inducible EIAV-based lentiviral vector packaging and producer cell lines

(2009) H J Stewart et al.   GENE THERAPY

Transduction of Nonhuman Primate Brain with Adeno-Associated Virus Serotype 1: Vector Trafficking and Immune Response

(2009) Piotr Hadaczek et al.   HUMAN GENE THERAPY

Global diffuse distribution in the brain and efficient gene delivery to the dorsal root ganglia by intrathecal injection of adeno-associated viral vector serotype 1

(2009) Naotaka Iwamoto et al.   JOURNAL OF GENE MEDICINE

A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro®) after intracerebral administration

(2009) Gillian Langford et al.   JOURNAL OF GENE MEDICINE

Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system

(2009) Nikolaus R. McFarland et al.   JOURNAL OF NEUROCHEMISTRY

Recombinant Adeno-Associated Virus Serotype 6 (rAAV2/6)-Mediated Gene Transfer to Nociceptive Neurons through Different Routes of Delivery

(2009) Chris Towne et al.   Molecular Pain

Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons

(2009) Sandra Duque et al.   MOLECULAR THERAPY

Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

(2009) Robert H Kutner et al.   Nature Protocols

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

(2009) C. W. Christine et al.   NEUROLOGY

CERVICAL SPINAL CORD THERAPEUTICS DELIVERY

(2009) Jonathan Riley et al.   NEUROSURGERY

CNS-directed gene therapy for lysosomal storage diseases

(2008) Mark S Sands et al.   ACTA PAEDIATRICA

Development and Applications of Non-HIV-Based Lentiviral Vectors in Neurological Disorders

(2008) Chiara Valori et al.   CURRENT GENE THERAPY

Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders

(2008) Cecilia Lundberg et al.   CURRENT GENE THERAPY

Therapeutic potential of CERE-110 (AAV2-NGF): Targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons

(2008) Kathie M. Bishop et al.   EXPERIMENTAL NEUROLOGY

Survival advantage of neonatal CNS gene transfer for late infantile neuronal ceroid lipofuscinosis

(2008) Dolan Sondhi et al.   EXPERIMENTAL NEUROLOGY

Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery

(2008) Alan H. Nagahara et al.   EXPERIMENTAL NEUROLOGY

Clinical gene therapy using recombinant adeno-associated virus vectors

(2008) C Mueller et al.   GENE THERAPY

Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis by CNS Administration of a Serotype 2 Adeno-Associated Virus Expressing CLN2 cDNA

(2008) Stefan Worgall et al.   HUMAN GENE THERAPY

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

(2008) William J Marks et al.   LANCET NEUROLOGY

A Phase I Trial of Ad.hIFN-β Gene Therapy for Glioma

(2008) E Antonio Chiocca et al.   MOLECULAR THERAPY

Systemic AAV6 Delivery Mediating RNA Interference Against SOD1: Neuromuscular Transduction Does Not Alter Disease Progression in fALS Mice

(2008) Chris Towne et al.   MOLECULAR THERAPY

Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1

(2008) Edmund R Hollis II et al.   MOLECULAR THERAPY

Transgene Expression, Bioactivity, and Safety of CERE-120 (AAV2-Neurturin) Following Delivery to the Monkey Striatum

(2008) Christopher D Herzog et al.   MOLECULAR THERAPY

Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles

(2008) Wuping Li et al.   MOLECULAR THERAPY

Ark floats gene therapy's boat, for now

(2008) Randy Osborne   NATURE BIOTECHNOLOGY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease

(2008) Shilpa Ramaswamy et al.   NEUROBIOLOGY OF DISEASE

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease

(2008) J. L. Eberling et al.   NEUROLOGY

Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain

(2008) B. Storek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA