Therapeutic potential of antisense oligonucleotides for the management of dyslipidemia
Published 2011 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Therapeutic potential of antisense oligonucleotides for the management of dyslipidemia
Authors
Keywords
-
Journal
Clinical Lipidology
Volume 6, Issue 6, Pages 675-692
Publisher
Future Medicine Ltd
Online
2011-12-01
DOI
10.2217/clp.11.59
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Anacetrapib and Dalcetrapib: Two Novel Cholesteryl Ester Transfer Protein Inhibitors
- (2011) Marta A Miyares ANNALS OF PHARMACOTHERAPY
- 760 MIPOMERSEN AN APOB SYNTHESIS INHIBITOR EVALUATION OF POTENTIAL TO REDUCE NECESSITY FOR LIPID-APHERESIS IN PATIENTS WITH HETEROZYGOUS FH AND CAD
- (2011) K.G. Parhofer et al. ATHEROSCLEROSIS SUPPLEMENTS
- Triglycerides and Cardiovascular Disease
- (2011) Michael Miller et al. CIRCULATION
- Emerging Targets for the Treatment of Dyslipidemia
- (2011) A. Tavridou et al. CURRENT MEDICINAL CHEMISTRY
- Functional validation of new pathways in lipoprotein metabolism identified by human genetics
- (2011) Robert C Bauer et al. CURRENT OPINION IN LIPIDOLOGY
- Antisense Oligonucleotides for the Treatment of Dyslipidemia
- (2011) I. Gouni-Berthold et al. CURRENT PHARMACEUTICAL DESIGN
- Lipoprotein(a): Medical Treatment Options for an Elusive Molecule
- (2011) Klaus G. Parhofer CURRENT PHARMACEUTICAL DESIGN
- Emerging options in the treatment of dyslipidemias: a bright future?
- (2011) Matilda Florentin et al. EXPERT OPINION ON EMERGING DRUGS
- Mipomersen, an antisense apolipoprotein B synthesis inhibitor
- (2011) Damon A Bell et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Cholesteryl ester transfer protein: The controversial relation to atherosclerosis and emerging new biological roles
- (2011) Helena C. F. Oliveira et al. IUBMB LIFE
- Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
- (2011) Katey J. Rayner et al. JOURNAL OF CLINICAL INVESTIGATION
- Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice
- (2011) Adam E. Mullick et al. JOURNAL OF LIPID RESEARCH
- Plasma apolipoprotein C-III metabolism in patients with chronic kidney disease
- (2011) Esther M. M. Ooi et al. JOURNAL OF LIPID RESEARCH
- Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism
- (2011) Guoping Li et al. JOURNAL OF LIPID RESEARCH
- Complexities of plasma apolipoprotein C-III metabolism: Fig. 1.
- (2011) Frank M. Sacks et al. JOURNAL OF LIPID RESEARCH
- APOLIPOPROTEIN B SYNTHESIS INHIBITION BY MIPOMERSEN REDUCES LOW-DENSITY LIPOPROTEIN CHOLESTEROL WHEN ADDED TO MAXIMALLY TOLERATED LIPID-LOWERING MEDICATION IN PATIENTS WITH SEVERE HETEROZYGOUS HYPERCHOLESTEROLEMIA
- (2011) Jean Claude Tardif et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Antisense Oligonucleotide Lowers Plasma Levels of Apolipoprotein (a) and Lipoprotein (a) in Transgenic Mice
- (2011) Esther Merki et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- SAFETY AND EFFICACY OF MIPOMERSEN ADMINISTERED AS ADD-ON THERAPY IN PATIENTS WITH HYPERCHOLESTEROLEMIA AND HIGH CARDIOVASCULAR RISK
- (2011) William C. Cromwell et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Targeting endogenous apo A-I—a new approach for raising HDL
- (2011) Prediman K. Shah Nature Reviews Cardiology
- Pharmacological strategies for lowering LDL cholesterol: statins and beyond
- (2011) Ariel Brautbar et al. Nature Reviews Cardiology
- HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms
- (2011) Mohamad Navab et al. Nature Reviews Cardiology
- Novel HDL-directed pharmacotherapeutic strategies
- (2011) Emil M. deGoma et al. Nature Reviews Cardiology
- Lowering apolipoprotein CIII delays onset of type 1 diabetes
- (2011) R. Holmberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of Mipomersen, an Apolipoprotein B Synthesis Inhibitor, on Low-Density Lipoprotein Cholesterol in Patients With Familial Hypercholesterolemia
- (2010) Fatima Akdim et al. AMERICAN JOURNAL OF CARDIOLOGY
- RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
- (2010) C. Frank Bennett et al. Annual Review of Pharmacology and Toxicology
- Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia
- (2010) Sandrine Caron et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assemblyThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.
- (2010) Angela C. Rutledge et al. Biochemistry and Cell Biology
- Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction
- (2010) Donald M. Lloyd-Jones et al. CIRCULATION
- Targeting ApoB as a therapeutic approach forthe treatment of dyslipidemia: the potential role of mipomersen
- (2010) Tiffany Thomas et al. Clinical Lipidology
- Gene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategies
- (2010) Sadik H Kassim et al. Clinical Lipidology
- Enigmatic Role of Lipoprotein(a) in Cardiovascular Disease
- (2010) Erdembileg Anuurad et al. CTS-Clinical and Translational Science
- Apolipoprotein B synthesis inhibition: results from clinical trials
- (2010) Maartje E Visser et al. CURRENT OPINION IN LIPIDOLOGY
- Combining genome-wide data from humans and animal models of dyslipidemia and atherosclerosis
- (2010) Stela Z Berisha et al. CURRENT OPINION IN LIPIDOLOGY
- MicroRNAs in lipid metabolism
- (2010) Carlos Fernández-Hernando et al. CURRENT OPINION IN LIPIDOLOGY
- Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2
- (2010) Arnold von Eckardstein et al. CURRENT OPINION IN LIPIDOLOGY
- Lipoprotein(a) as a cardiovascular risk factor: current status
- (2010) Børge G. Nordestgaard et al. EUROPEAN HEART JOURNAL
- Inflammation reduces HDL protection against primary cardiac risk
- (2010) James P. Corsetti et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Mipomersen as a potential adjunctive therapy for hypercholesterolemia
- (2010) Neeraj Patel et al. EXPERT OPINION ON PHARMACOTHERAPY
- Decreased Expression ofARV1Results in Cholesterol Retention in the Endoplasmic Reticulum and Abnormal Bile Acid Metabolism
- (2010) Fumin Tong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of Acyl-Coenzyme A:Cholesterol Acyltransferase 2 (ACAT2) Prevents Dietary Cholesterol-associated Steatosis by Enhancing Hepatic Triglyceride Mobilization
- (2010) Heather M. Alger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
- (2010) J. Mark Brown et al. JOURNAL OF LIPID RESEARCH
- Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy
- (2010) Fatima Akdim et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial
- (2010) Frederick J Raal et al. LANCET
- 24, 25-Dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression
- (2010) Kent R. Wehmeier et al. LIFE SCIENCES
- Biological, clinical and population relevance of 95 loci for blood lipids
- (2010) Tanya M. Teslovich et al. NATURE
- Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease
- (2010) Kitt Falk Petersen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomewide Association Studies and Assessment of the Risk of Disease
- (2010) Teri A. Manolio NEW ENGLAND JOURNAL OF MEDICINE
- Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease
- (2010) Christopher P. Cannon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates
- (2010) Ellen Marie Straarup et al. NUCLEIC ACIDS RESEARCH
- Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion
- (2010) Meenakshi Sundaram et al. Nutrition & Metabolism
- Molecular pathways and agents for lowering LDL-cholesterol in addition to statins
- (2010) Philippe Costet PHARMACOLOGY & THERAPEUTICS
- A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo
- (2010) Nidhi Gupta et al. PLoS One
- miR-33 links SREBP-2 induction to repression of sterol transporters
- (2010) T. J. Marquart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Framingham Heart Study's Impact on Global Risk Assessment
- (2010) Asaf Bitton et al. PROGRESS IN CARDIOVASCULAR DISEASES
- MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
- (2010) S. H. Najafi-Shoushtari et al. SCIENCE
- MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
- (2010) K. J. Rayner et al. SCIENCE
- RNAi and small interfering RNAs in human disease therapeutic applications
- (2010) Monica R. Lares et al. TRENDS IN BIOTECHNOLOGY
- microRNAs and cholesterol metabolism
- (2010) Kathryn J. Moore et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- High density lipoprotein: it's not just about lipid transport anymore
- (2010) Scott M. Gordon et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 Inhibition Prevents the Metabolic Syndrome and Atherosclerosis
- (2009) J. Mark Brown et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins
- (2009) Carlos O. Mendivil et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- MicroRNAs: Target Recognition and Regulatory Functions
- (2009) David P. Bartel CELL
- Development of Apolipoprotein B Antisense Molecules as a Therapy for Hyperlipidemia
- (2009) Tiffany Thomas et al. Current Atherosclerosis Reports
- Triglycerides as vascular risk factors: new epidemiologic insights
- (2009) William B Kannel et al. CURRENT OPINION IN CARDIOLOGY
- Growing Epidemic of Coronary Heart Disease in Low- and Middle-Income Countries
- (2009) Thomas A. Gaziano et al. CURRENT PROBLEMS IN CARDIOLOGY
- Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors
- (2009) M. J. Chapman et al. EUROPEAN HEART JOURNAL
- Antisense oligonucleotide pharmacokinetics and metabolism
- (2009) Richard S Geary Expert Opinion on Drug Metabolism & Toxicology
- Ribonuclease H: the enzymes in eukaryotes
- (2009) Susana M. Cerritelli et al. FEBS Journal
- Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids
- (2009) Claudio J. Villanueva et al. HEPATOLOGY
- Binding and Cleavage Specificities of Human Argonaute2
- (2009) Walt F. Lima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nonsynonymous Mutations withinAPOBin Human Familial Hypobetalipoproteinemia
- (2009) Shumei Zhong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia
- (2009) Maartje E. Visser et al. JOURNAL OF LIPID RESEARCH
- Anakinra for Rheumatoid Arthritis: A Systematic Review
- (2009) M. MERTENS et al. JOURNAL OF RHEUMATOLOGY
- Apolipoprotein C-III predicts cardiovascular mortality in severe coronary artery disease and is associated with an enhanced plasma thrombin generation
- (2009) O. OLIVIERI et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
- (2009) Robert Clarke et al. NEW ENGLAND JOURNAL OF MEDICINE
- SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
- (2009) D. M. Erion et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice
- (2008) Xing Xian Yu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Inhibition of ADRP prevents diet-induced insulin resistance
- (2008) Gladys M. Varela et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100
- (2008) Rosie Z. Yu et al. BIOCHEMICAL PHARMACOLOGY
- Knockdown of Acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice
- (2008) Ying Liu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Tumor necrosis factor alpha drugs in rheumatoid arthritis: systematic review and metaanalysis of efficacy and safety
- (2008) Alberto Alonso-Ruiz et al. BMC MUSCULOSKELETAL DISORDERS
- Antisense Oligonucleotide Directed to Human Apolipoprotein B-100 Reduces Lipoprotein(a) Levels and Oxidized Phospholipids on Human Apolipoprotein B-100 Particles in Lipoprotein(a) Transgenic Mice
- (2008) Esther Merki et al. CIRCULATION
- Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis
- (2008) J. Mark Brown et al. CIRCULATION
- Apolipoprotein CIII Links Hyperlipidemia With Vascular Endothelial Cell Dysfunction
- (2008) Akio Kawakami et al. CIRCULATION
- Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase
- (2008) Vladimir Savransky et al. CIRCULATION RESEARCH
- Lack of Pharmacokinetic Interaction of Mipomersen Sodium (ISIS 301012), a 2′-O-Methoxyethyl Modified Antisense Oligonucleotide Targeting Apolipoprotein B-100 Messenger RNA, with Simvastatin and Ezetimibe
- (2008) Rosie Z Yu et al. CLINICAL PHARMACOKINETICS
- Apolipoprotein C-III: understanding an emerging cardiovascular risk factor
- (2008) Esther M. M. Ooi et al. CLINICAL SCIENCE
- HDL metabolism in context: looking on the bright side
- (2008) Gerald F Watts et al. CURRENT OPINION IN LIPIDOLOGY
- Recurrence of Cardiovascular Events in Patients With Type 2 Diabetes: Epidemiology and risk factors
- (2008) C. B. Giorda et al. DIABETES CARE
- Antisense technology for the prevention or the treatment of cardiovascular disease: The next blockbuster?
- (2008) Vasilios G Athyros et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models
- (2008) Elizabeth P. Newberry et al. HEPATOLOGY
- An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor?
- (2008) D. C. Chan et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Liver lipid metabolism
- (2008) P. Nguyen et al. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
- Targeted Depletion of Hepatic ACAT2-driven Cholesterol Esterification Reveals a Non-biliary Route for Fecal Neutral Sterol Loss
- (2008) J. Mark Brown et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals
- (2008) Punit P. Seth et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection
- (2008) T. I. Pollin et al. SCIENCE
- Differential regulation of apolipoprotein A-I gene expression by vitamin D receptor modulators
- (2007) Kent R. Wehmeier et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Inhibition of microRNA with antisense oligonucleotides
- (2007) Christine C. Esau METHODS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More