Therapeutic potential of antisense oligonucleotides for the management of dyslipidemia
出版年份 2011 全文链接
标题
Therapeutic potential of antisense oligonucleotides for the management of dyslipidemia
作者
关键词
-
出版物
Clinical Lipidology
Volume 6, Issue 6, Pages 675-692
出版商
Future Medicine Ltd
发表日期
2011-12-01
DOI
10.2217/clp.11.59
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Anacetrapib and Dalcetrapib: Two Novel Cholesteryl Ester Transfer Protein Inhibitors
- (2011) Marta A Miyares ANNALS OF PHARMACOTHERAPY
- 760 MIPOMERSEN AN APOB SYNTHESIS INHIBITOR EVALUATION OF POTENTIAL TO REDUCE NECESSITY FOR LIPID-APHERESIS IN PATIENTS WITH HETEROZYGOUS FH AND CAD
- (2011) K.G. Parhofer et al. ATHEROSCLEROSIS SUPPLEMENTS
- Triglycerides and Cardiovascular Disease
- (2011) Michael Miller et al. CIRCULATION
- Emerging Targets for the Treatment of Dyslipidemia
- (2011) A. Tavridou et al. CURRENT MEDICINAL CHEMISTRY
- Functional validation of new pathways in lipoprotein metabolism identified by human genetics
- (2011) Robert C Bauer et al. CURRENT OPINION IN LIPIDOLOGY
- Antisense Oligonucleotides for the Treatment of Dyslipidemia
- (2011) I. Gouni-Berthold et al. CURRENT PHARMACEUTICAL DESIGN
- Lipoprotein(a): Medical Treatment Options for an Elusive Molecule
- (2011) Klaus G. Parhofer CURRENT PHARMACEUTICAL DESIGN
- Emerging options in the treatment of dyslipidemias: a bright future?
- (2011) Matilda Florentin et al. EXPERT OPINION ON EMERGING DRUGS
- Mipomersen, an antisense apolipoprotein B synthesis inhibitor
- (2011) Damon A Bell et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Cholesteryl ester transfer protein: The controversial relation to atherosclerosis and emerging new biological roles
- (2011) Helena C. F. Oliveira et al. IUBMB LIFE
- Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
- (2011) Katey J. Rayner et al. JOURNAL OF CLINICAL INVESTIGATION
- Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice
- (2011) Adam E. Mullick et al. JOURNAL OF LIPID RESEARCH
- Plasma apolipoprotein C-III metabolism in patients with chronic kidney disease
- (2011) Esther M. M. Ooi et al. JOURNAL OF LIPID RESEARCH
- Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism
- (2011) Guoping Li et al. JOURNAL OF LIPID RESEARCH
- Complexities of plasma apolipoprotein C-III metabolism: Fig. 1.
- (2011) Frank M. Sacks et al. JOURNAL OF LIPID RESEARCH
- APOLIPOPROTEIN B SYNTHESIS INHIBITION BY MIPOMERSEN REDUCES LOW-DENSITY LIPOPROTEIN CHOLESTEROL WHEN ADDED TO MAXIMALLY TOLERATED LIPID-LOWERING MEDICATION IN PATIENTS WITH SEVERE HETEROZYGOUS HYPERCHOLESTEROLEMIA
- (2011) Jean Claude Tardif et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Antisense Oligonucleotide Lowers Plasma Levels of Apolipoprotein (a) and Lipoprotein (a) in Transgenic Mice
- (2011) Esther Merki et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- SAFETY AND EFFICACY OF MIPOMERSEN ADMINISTERED AS ADD-ON THERAPY IN PATIENTS WITH HYPERCHOLESTEROLEMIA AND HIGH CARDIOVASCULAR RISK
- (2011) William C. Cromwell et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Targeting endogenous apo A-I—a new approach for raising HDL
- (2011) Prediman K. Shah Nature Reviews Cardiology
- Pharmacological strategies for lowering LDL cholesterol: statins and beyond
- (2011) Ariel Brautbar et al. Nature Reviews Cardiology
- HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms
- (2011) Mohamad Navab et al. Nature Reviews Cardiology
- Novel HDL-directed pharmacotherapeutic strategies
- (2011) Emil M. deGoma et al. Nature Reviews Cardiology
- Lowering apolipoprotein CIII delays onset of type 1 diabetes
- (2011) R. Holmberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of Mipomersen, an Apolipoprotein B Synthesis Inhibitor, on Low-Density Lipoprotein Cholesterol in Patients With Familial Hypercholesterolemia
- (2010) Fatima Akdim et al. AMERICAN JOURNAL OF CARDIOLOGY
- RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
- (2010) C. Frank Bennett et al. Annual Review of Pharmacology and Toxicology
- Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia
- (2010) Sandrine Caron et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assemblyThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.
- (2010) Angela C. Rutledge et al. Biochemistry and Cell Biology
- Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction
- (2010) Donald M. Lloyd-Jones et al. CIRCULATION
- Targeting ApoB as a therapeutic approach forthe treatment of dyslipidemia: the potential role of mipomersen
- (2010) Tiffany Thomas et al. Clinical Lipidology
- Gene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategies
- (2010) Sadik H Kassim et al. Clinical Lipidology
- Enigmatic Role of Lipoprotein(a) in Cardiovascular Disease
- (2010) Erdembileg Anuurad et al. CTS-Clinical and Translational Science
- Apolipoprotein B synthesis inhibition: results from clinical trials
- (2010) Maartje E Visser et al. CURRENT OPINION IN LIPIDOLOGY
- Combining genome-wide data from humans and animal models of dyslipidemia and atherosclerosis
- (2010) Stela Z Berisha et al. CURRENT OPINION IN LIPIDOLOGY
- MicroRNAs in lipid metabolism
- (2010) Carlos Fernández-Hernando et al. CURRENT OPINION IN LIPIDOLOGY
- Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2
- (2010) Arnold von Eckardstein et al. CURRENT OPINION IN LIPIDOLOGY
- Lipoprotein(a) as a cardiovascular risk factor: current status
- (2010) Børge G. Nordestgaard et al. EUROPEAN HEART JOURNAL
- Inflammation reduces HDL protection against primary cardiac risk
- (2010) James P. Corsetti et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Mipomersen as a potential adjunctive therapy for hypercholesterolemia
- (2010) Neeraj Patel et al. EXPERT OPINION ON PHARMACOTHERAPY
- Decreased Expression ofARV1Results in Cholesterol Retention in the Endoplasmic Reticulum and Abnormal Bile Acid Metabolism
- (2010) Fumin Tong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of Acyl-Coenzyme A:Cholesterol Acyltransferase 2 (ACAT2) Prevents Dietary Cholesterol-associated Steatosis by Enhancing Hepatic Triglyceride Mobilization
- (2010) Heather M. Alger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
- (2010) J. Mark Brown et al. JOURNAL OF LIPID RESEARCH
- Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy
- (2010) Fatima Akdim et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial
- (2010) Frederick J Raal et al. LANCET
- 24, 25-Dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression
- (2010) Kent R. Wehmeier et al. LIFE SCIENCES
- Biological, clinical and population relevance of 95 loci for blood lipids
- (2010) Tanya M. Teslovich et al. NATURE
- Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease
- (2010) Kitt Falk Petersen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomewide Association Studies and Assessment of the Risk of Disease
- (2010) Teri A. Manolio NEW ENGLAND JOURNAL OF MEDICINE
- Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease
- (2010) Christopher P. Cannon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates
- (2010) Ellen Marie Straarup et al. NUCLEIC ACIDS RESEARCH
- Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion
- (2010) Meenakshi Sundaram et al. Nutrition & Metabolism
- Molecular pathways and agents for lowering LDL-cholesterol in addition to statins
- (2010) Philippe Costet PHARMACOLOGY & THERAPEUTICS
- A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo
- (2010) Nidhi Gupta et al. PLoS One
- miR-33 links SREBP-2 induction to repression of sterol transporters
- (2010) T. J. Marquart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Framingham Heart Study's Impact on Global Risk Assessment
- (2010) Asaf Bitton et al. PROGRESS IN CARDIOVASCULAR DISEASES
- MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
- (2010) S. H. Najafi-Shoushtari et al. SCIENCE
- MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
- (2010) K. J. Rayner et al. SCIENCE
- RNAi and small interfering RNAs in human disease therapeutic applications
- (2010) Monica R. Lares et al. TRENDS IN BIOTECHNOLOGY
- microRNAs and cholesterol metabolism
- (2010) Kathryn J. Moore et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- High density lipoprotein: it's not just about lipid transport anymore
- (2010) Scott M. Gordon et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 Inhibition Prevents the Metabolic Syndrome and Atherosclerosis
- (2009) J. Mark Brown et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins
- (2009) Carlos O. Mendivil et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- MicroRNAs: Target Recognition and Regulatory Functions
- (2009) David P. Bartel CELL
- Development of Apolipoprotein B Antisense Molecules as a Therapy for Hyperlipidemia
- (2009) Tiffany Thomas et al. Current Atherosclerosis Reports
- Triglycerides as vascular risk factors: new epidemiologic insights
- (2009) William B Kannel et al. CURRENT OPINION IN CARDIOLOGY
- Growing Epidemic of Coronary Heart Disease in Low- and Middle-Income Countries
- (2009) Thomas A. Gaziano et al. CURRENT PROBLEMS IN CARDIOLOGY
- Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors
- (2009) M. J. Chapman et al. EUROPEAN HEART JOURNAL
- Antisense oligonucleotide pharmacokinetics and metabolism
- (2009) Richard S Geary Expert Opinion on Drug Metabolism & Toxicology
- Ribonuclease H: the enzymes in eukaryotes
- (2009) Susana M. Cerritelli et al. FEBS Journal
- Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids
- (2009) Claudio J. Villanueva et al. HEPATOLOGY
- Binding and Cleavage Specificities of Human Argonaute2
- (2009) Walt F. Lima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nonsynonymous Mutations withinAPOBin Human Familial Hypobetalipoproteinemia
- (2009) Shumei Zhong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia
- (2009) Maartje E. Visser et al. JOURNAL OF LIPID RESEARCH
- Anakinra for Rheumatoid Arthritis: A Systematic Review
- (2009) M. MERTENS et al. JOURNAL OF RHEUMATOLOGY
- Apolipoprotein C-III predicts cardiovascular mortality in severe coronary artery disease and is associated with an enhanced plasma thrombin generation
- (2009) O. OLIVIERI et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
- (2009) Robert Clarke et al. NEW ENGLAND JOURNAL OF MEDICINE
- SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
- (2009) D. M. Erion et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice
- (2008) Xing Xian Yu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Inhibition of ADRP prevents diet-induced insulin resistance
- (2008) Gladys M. Varela et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100
- (2008) Rosie Z. Yu et al. BIOCHEMICAL PHARMACOLOGY
- Knockdown of Acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice
- (2008) Ying Liu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Tumor necrosis factor alpha drugs in rheumatoid arthritis: systematic review and metaanalysis of efficacy and safety
- (2008) Alberto Alonso-Ruiz et al. BMC MUSCULOSKELETAL DISORDERS
- Antisense Oligonucleotide Directed to Human Apolipoprotein B-100 Reduces Lipoprotein(a) Levels and Oxidized Phospholipids on Human Apolipoprotein B-100 Particles in Lipoprotein(a) Transgenic Mice
- (2008) Esther Merki et al. CIRCULATION
- Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis
- (2008) J. Mark Brown et al. CIRCULATION
- Apolipoprotein CIII Links Hyperlipidemia With Vascular Endothelial Cell Dysfunction
- (2008) Akio Kawakami et al. CIRCULATION
- Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase
- (2008) Vladimir Savransky et al. CIRCULATION RESEARCH
- Lack of Pharmacokinetic Interaction of Mipomersen Sodium (ISIS 301012), a 2′-O-Methoxyethyl Modified Antisense Oligonucleotide Targeting Apolipoprotein B-100 Messenger RNA, with Simvastatin and Ezetimibe
- (2008) Rosie Z Yu et al. CLINICAL PHARMACOKINETICS
- Apolipoprotein C-III: understanding an emerging cardiovascular risk factor
- (2008) Esther M. M. Ooi et al. CLINICAL SCIENCE
- HDL metabolism in context: looking on the bright side
- (2008) Gerald F Watts et al. CURRENT OPINION IN LIPIDOLOGY
- Recurrence of Cardiovascular Events in Patients With Type 2 Diabetes: Epidemiology and risk factors
- (2008) C. B. Giorda et al. DIABETES CARE
- Antisense technology for the prevention or the treatment of cardiovascular disease: The next blockbuster?
- (2008) Vasilios G Athyros et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models
- (2008) Elizabeth P. Newberry et al. HEPATOLOGY
- An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor?
- (2008) D. C. Chan et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Liver lipid metabolism
- (2008) P. Nguyen et al. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
- Targeted Depletion of Hepatic ACAT2-driven Cholesterol Esterification Reveals a Non-biliary Route for Fecal Neutral Sterol Loss
- (2008) J. Mark Brown et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals
- (2008) Punit P. Seth et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection
- (2008) T. I. Pollin et al. SCIENCE
- Differential regulation of apolipoprotein A-I gene expression by vitamin D receptor modulators
- (2007) Kent R. Wehmeier et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Inhibition of microRNA with antisense oligonucleotides
- (2007) Christine C. Esau METHODS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started