Article
Peripheral Vascular Disease
Mario Zanaty, Fernando A. C. Seara, Pablo Nakagawa, Guorui Deng, Natalia M. Mathieu, Kirthikaa Balapattabi, Sadashiva S. Karnik, Justin L. Grobe, Curt D. Sigmund
Summary: The study found that intracerebroventricular administration of TRV027 can increase aversion to saline and lower blood pressure in a model of salt-sensitive hypertension. Both TRV027 and losartan increased aversion to saline, with a more pronounced effect on highly aversive saline solutions.
Article
Cardiac & Cardiovascular Systems
Patrick J. Trainor, Michela Brambatti, Samantha M. Carlisle, Adam E. Mullick, Sanjiv J. Shah, Tanvir Kahlon, Diana Otero Mostacero, Hossein Mousavi, Erin S. Morgan, Yvonne Tami, Erin D. Michos, Pamela Ouyang, Sotirios Tsimikas, Andrew P. DeFilippis
Summary: This study explores the relationship between circulating angiotensinogen levels and ethnicity, sex, blood pressure (BP), and hypertension. The results suggest significant differences in angiotensinogen levels between sexes and ethnicities, with a positive association between levels and prevalent hypertension and BP, which differs between sexes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Miguel Vazquez-Moreno, Daniel Locia-Morales, Jose Peralta-Romero, Tanmay Sharma, David Meyre, Miguel Cruz, Eugenia Flores-Alfaro, Adan Valladares-Salgado
Summary: The AGT rs4762 A allele is positively associated with diastolic blood pressure in Mexican individuals with type 2 diabetes, particularly in those with diabetic nephropathy.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Health Care Sciences & Services
Qiao-Ying Wu, Yu Feng, Li-Li Wang, Xue-Hui Zhang
Summary: The study found that Apelin-12 levels decrease with disease progression, while AT1R and AGT levels increase. Changes in levels of Apelin-12, AT1R, and AGT are significant in judging the degree of renal fibrosis in patients with IgA nephropathy, with AGT levels showing the highest correlation with the degree of renal fibrosis.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Cell Biology
Janine Giovanella, Luana Maria Wollinger, Luisa Capra, Fabiane Dresch, Julia Pasqualini Genro, Veronica Contini
Summary: The study revealed significant interactions between genetic polymorphisms (rs699-AGT and rs1799722-BDKRB2) and the consumption of micronutrients (sodium, magnesium, and calcium) on blood pressure variation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Peripheral Vascular Disease
Cheol Ho Park, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Joongyub Lee, Suah Sung, Ji Yong Jung, Young Youl Hyun, Kook-Hwan Oh, Shin-Wook Kang, Seung Hyeok Han
Summary: This study found that higher systolic blood pressure (SBP) was associated with the progression of chronic kidney disease (CKD) when urinary angiotensinogen levels were low, but this association was not observed when urinary angiotensinogen levels were high. This finding suggests that intrarenal renin-angiotensin system activity may modify the relationship between SBP and adverse kidney outcome.
Article
Medicine, General & Internal
Akshay S. Desai, David J. Webb, Jorg Taubel, Sarah Casey, Yansong Cheng, Gabriel J. Robbie, Don Foster, Stephen A. Huang, Sean Rhyee, Marianne T. Sweetser, George L. Bakris
Summary: Zilebesiran, an investigational RNA interference therapeutic agent, showed dose-dependent decreases in serum angiotensinogen levels and sustained blood pressure-lowering effect for up to 24 weeks in patients with hypertension. High-salt diet attenuated the blood pressure-lowering effect, while coadministration with irbesartan augmented the effect. Mild injection-site reactions were observed in a few patients throughout the study.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ryousuke Satou, Martha Franco, Courtney M. Dugas, Akemi Katsurada, L. Gabriel Navar
Summary: This study demonstrates the beneficial effects of immunosuppression by mycophenolate mofetil (MMF) on the augmentation of intrarenal angiotensinogen (AGT) in hypertension. MMF treatment attenuates the activation of renal macrophages and the production of pro-inflammatory cytokines, leading to the normalization of AGT levels and the amelioration of hypertensive kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Rasmus Dreier, Ulrik B. Andersen, Julie L. Forman, Majid Sheykhzade, Martin Egfjord, Jorgen L. Jeppesen
Summary: Increasing potassium intake raises plasma potassium and aldosterone levels, potentiating AngII-stimulated aldosterone secretion without affecting systemic cardiovascular hemodynamics in healthy normotensive men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, William Wheatley, Jae Min Cho, J. David Symons, Donald E. Kohan
Summary: Loss of sPRR reduces baseline blood pressure, decreases Ang II-induced hypertension and renal injury, and is associated with greater endothelium-dependent vasorelaxation of resistance-sized arteries.
CIRCULATION RESEARCH
(2021)
Review
Medicine, General & Internal
Qian Zhang, Qingning Huang, Xianen Wang, Yong Wang, Xiaofang Hua
Summary: In this meta-analysis, AGT M235T was found to be associated with CAD susceptibility in the Eastern Asian population, particularly in the Chinese population. Additionally, the T174M polymorphism was also found to be correlated with CAD risk in the Eastern Asian population.
Article
Hematology
Jeff Z. Chen, Hisashi Sawada, Dien Ye, Yuriko Katsumata, Masayoshi Kukida, Satoko Ohno-Urabe, Jessica J. Moorleghen, Michael K. Franklin, Deborah A. Howatt, Mary B. Sheppard, Adam E. Mullick, Hong S. Lu, Alan Daugherty
Summary: Deletion of AT1aR and inhibition of Ang II production had similar effects in attenuating pathologies in the proximal thoracic aorta of male Fbn1(C1041G/+) mice. Inhibition of the renin-angiotensin system attenuated dysregulation of genes within the aorta related to pathology of Fbn1(C1041G/+) mice.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng
Summary: The study revealed that TMAO can enhance Ang II-induced hypertension and mediate Ang II-induced vasoconstriction, possibly through the PERK/ROS/CaMKII/PLC beta 3 pathway.
Article
Chemistry, Medicinal
Qi Zhang, Yue Shen, Sayeman Islam Niloy, Stephen T. O'Rourke, Chengwen Sun
Summary: This study found that chronic infusion of apelin-13 does not change blood pressure or heart rate, and does not alter Ang II-induced hypertension and cardiac hypertrophy. These findings suggest that an APJ receptor biased agonist could be a better therapeutic alternative for treatment of hypertension.
Article
Pharmacology & Pharmacy
Francesca E. Mowry, Sarah C. Peaden, Javier E. Stern, Vinicia C. Biancardi
Summary: The study demonstrates that inhibiting TLR4 and AT1R in hypertensive rats can restore neuroinflammation, blood-brain barrier disruption, and autonomic dysfunction, suggesting a potential therapeutic approach for hypertension.
PHARMACOLOGICAL RESEARCH
(2021)
