TLR4 and AT1R mediate blood-brain barrier disruption, neuroinflammation, and autonomic dysfunction in spontaneously hypertensive rats

Intracranial Pressure During the Development of Renovascular Hypertension

(2021) Marcos Vinicius Fernandes et al.   HYPERTENSION

Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR

(2020) Meng-Lu Xu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Neuronal Networks in Hypertension

(2020) Patrice G. Guyenet et al.   HYPERTENSION

Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension

(2020) Monica M. Santisteban et al.   HYPERTENSION

Regulation of blood–brain barrier integrity by microglia in health and disease: A therapeutic opportunity

(2020) Patrick T Ronaldson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prevalence of Apparent Treatment-Resistant Hypertension in the United States

(2019) Robert M. Carey et al.   HYPERTENSION

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Toll-Like Receptor 4 and Blood Pressure: Lessons From Animal Studies

(2019) Kenia Pedrosa Nunes et al.   Frontiers in Physiology

Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension

(2019) Qing Yang et al.   Neuroscience Bulletin

Exercise Training Attenuates Hypertension Through TLR4/MyD88/NF-κB Signaling in the Hypothalamic Paraventricular Nucleus

(2019) Jie Qi et al.   Frontiers in Neuroscience

Kefir ameliorates hypertension via gut–brain mechanisms in spontaneously hypertensive rats

(2019) Mirian de Almeida Silva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Targeting TLR4 signaling pathways: can therapeutics pay the toll for hypertension?

(2018) Kenia Pedrosa Nunes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neurogenic hypertension: pathophysiology, diagnosis and management

(2018) Samuel J. Mann   CLINICAL AUTONOMIC RESEARCH

The benefits of soluble non-bacterial fraction of kefir on blood pressure and cardiac hypertrophy in hypertensive rats are mediated by an increase in baroreflex sensitivity and decrease in angiotensin-converting enzyme activity

(2018) Girlandia Alexandre Brasil et al.   NUTRITION

Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states

(2018) Roger A. Dampney et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rostral Ventrolateral Medulla and Hypertension

(2018) Patrice G. Guyenet et al.   HYPERTENSION

Microglia in the RVLM of SHR have reduced P2Y12R and CX3CR1 expression, shorter processes, and lower cell density

(2018) E. Myfanwy Cohen et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Recent Advances in Neurogenic Hypertension

(2017) Sean D. Stocker et al.   HYPERTENSION

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The interplay between Angiotensin II, TLR4 and hypertension

(2017) Vinicia Campana Biancardi et al.   PHARMACOLOGICAL RESEARCH

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

(2017) Sandra Zárate et al.   Frontiers in Aging Neuroscience

Maintenance of Blood-Brain Barrier Integrity in Hypertension: A Novel Benefit of Exercise Training for Autonomic Control

(2017) Leila Buttler et al.   Frontiers in Physiology

Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus

(2016) Vinicia Campana Biancardi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Astrocytes Contribute to Angiotensin II Stimulation of Hypothalamic Neuronal Activity and Sympathetic OutflowNovelty and Significance

(2016) Javier E. Stern et al.   HYPERTENSION

TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension

(2016) Hong-Bao Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats

(2016) Clênia de Oliveira Cavalcanti et al.   Frontiers in Physiology

The Sympathetic Nervous System Alterations in Human Hypertension

(2015) G. Grassi et al.   CIRCULATION RESEARCH

Angiotensin-II, the Brain, and Hypertension

(2015) Colin N. Young et al.   HYPERTENSION

Microglia Participate in Neurogenic Regulation of HypertensionNovelty and Significance

(2015) Xiao Z. Shen et al.   HYPERTENSION

TAK-242, an Antagonist for Toll-like Receptor 4, Protects against Acute Cerebral Ischemia/Reperfusion Injury in Mice

(2015) Fang Hua et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Toll-like receptor 4 inhibition within the paraventricular nucleus attenuates blood pressure and inflammatory response in a genetic model of hypertension

(2015) Rahul B Dange et al.   Journal of Neuroinflammation

Antihypertensive effects of probioticsLactobacillusstrains in spontaneously hypertensive rats

(2015) Manuel Gómez-Guzmán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Central blockade of TLR4 improves cardiac function and attenuates myocardial inflammation in angiotensin II-induced hypertension

(2014) Rahul B. Dange et al.   CARDIOVASCULAR RESEARCH

The Autonomic Nervous System and Hypertension

(2014) Giuseppe Mancia et al.   CIRCULATION RESEARCH

Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats

(2014) Xin-Ai Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities

(2014) Daniel B. Zoccal et al.   Frontiers in Physiology

Cardiac sympathetic dysfunction in the prehypertensive spontaneously hypertensive rat

(2013) Julia Shanks et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sympathetic Nervous System and Hypertension

(2013) Gerald F. DiBona   HYPERTENSION

Circulating Angiotensin II Gains Access to the Hypothalamus and Brain Stem During Hypertension via Breakdown of the Blood–Brain Barrier

(2013) Vinicia Campana Biancardi et al.   HYPERTENSION

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

Intra-carotid angiotensin II activates tyrosine hydroxylase-expressing rostral ventrolateral medulla neurons following blood–brain barrier disruption in rats

(2013) S.T. Yao et al.   NEUROSCIENCE

Partially Silencing Brain Toll-Like Receptor 4 Prevents in Part Left Ventricular Remodeling with Sympathoinhibition in Rats with Myocardial Infarction-Induced Heart Failure

(2013) Kiyohiro Ogawa et al.   PLoS One

Toll-Like Receptor 4 Antagonist Attenuates Intracerebral Hemorrhage–Induced Brain Injury

(2013) Yan-Chun Wang et al.   STROKE

Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats

(2012) Gisele F. Bomfim et al.   CLINICAL SCIENCE

Inflammatory cytokines in paraventricular nucleus modulate sympathetic activity and cardiac sympathetic afferent reflex in rats

(2011) Z. Shi et al.   Acta Physiologica

Autonomic-Immune-Vascular Interaction

(2011) Jasenka Zubcevic et al.   HYPERTENSION

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Brain AT1 Receptor Activates the Sympathetic Nervous System Through Toll-like Receptor 4 in Mice With Heart Failure

(2011) Kiyohiro Ogawa et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Contributions of vascular inflammation in the brainstem for neurogenic hypertension

(2011) Hidefumi Waki et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Brain Microglial Cytokines in Neurogenic Hypertension

(2010) Peng Shi et al.   HYPERTENSION

Centrally administered lipopolysaccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling

(2010) Zhi-Hua Zhang et al.   JOURNAL OF HYPERTENSION

Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation

(2010) Julius Benicky et al.   NEUROPSYCHOPHARMACOLOGY

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

(2009) K Takashima et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension

(2009) Y.-M. Kang et al.   CARDIOVASCULAR RESEARCH

Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery

(2009) Julius Benicky et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Validation of Volume-Pressure Recording Tail-Cuff Blood Pressure Measurements

(2008) M. Feng et al.   AMERICAN JOURNAL OF HYPERTENSION

Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: does it contribute to hypertension?

(2008) Annabel E. Simms et al.   JOURNAL OF PHYSIOLOGY-LONDON