CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

Adipose tissue as an immunological organ

(2015) Ryan W. Grant et al.   Obesity

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

(2014) Tracey McLaughlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Coinhibitory Suppression of T Cell Activation by CD40 Protects Against Obesity and Adipose Tissue Inflammation in Mice

(2014) Dennis Wolf et al.   CIRCULATION

CD40-Mediated Maintenance of Immune Homeostasis in the Adipose Tissue Microenvironment

(2014) Z. Yi et al.   DIABETES

Immune Cell Crosstalk in Obesity: A Key Role for Costimulation?

(2014) T. Seijkens et al.   DIABETES

Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation

(2014) Antonios Chatzigeorgiou et al.   HEPATOLOGY

Signals and pathways controlling regulatory T cells

(2014) Alexandria Huynh et al.   IMMUNOLOGICAL REVIEWS

Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice

(2014) S M van den Berg et al.   INTERNATIONAL JOURNAL OF OBESITY

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

(2014) A. Chatzigeorgiou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Appearance and disappearance of the mRNA signature characteristic of Tregcells in visceral adipose tissue: Age, diet, and PPARγ effects

(2014) Daniela Cipolletta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation

(2014) Kae Won Cho et al.   Cell Reports

CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance

(2013) Chang-An Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Immunological Goings-on in Visceral Adipose Tissue

(2013) Diane Mathis   Cell Metabolism

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

(2013) Tuo Deng et al.   Cell Metabolism

T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance

(2013) J. Zhong et al.   DIABETES

Adipose Tissue Macrophages Function As Antigen-Presenting Cells and Regulate Adipose Tissue CD4 + T Cells in Mice

(2013) David L. Morris et al.   DIABETES

CD40L Stimulates the Crosstalk Between Adipocytes and Inflammatory Cells

(2013) A. Chatzigeorgiou et al.   HORMONE AND METABOLIC RESEARCH

Neuropeptide Y Is Produced by Adipose Tissue Macrophages and Regulates Obesity-Induced Inflammation

(2013) Kanakadurga Singer et al.   PLoS One

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway

(2012) Qin-Qin Lin et al.   CYTOKINE

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

(2012) Shawn Winer et al.   IMMUNOLOGY AND CELL BIOLOGY

CX3CR1 Deficiency Does Not Influence Trafficking of Adipose Tissue Macrophages in Mice With Diet-Induced Obesity

(2012) David L. Morris et al.   Obesity

CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice

(2011) Marjorie Poggi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation

(2010) Michael Spencer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

(2010) Esther Lutgens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance

(2010) H. Yang et al.   JOURNAL OF IMMUNOLOGY

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

(2010) M. Feuerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac allograft acceptance induced by blockade of CD40-CD40L costimulation is dependent on CD4+CD25+ regulatory T cells

(2010) Xiaofeng Jiang et al.   SURGERY

CD40L-CD40 fuel ignites obesity

(2010) Marjorie Poggi et al.   THROMBOSIS AND HAEMOSTASIS

CD40L induces inflammation and adipogenesis in adipose cells – a potential link between metabolic and cardiovascular disease

(2010) Isabel Platzer et al.   THROMBOSIS AND HAEMOSTASIS

The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes

(2009) M. Poggi et al.   DIABETOLOGIA

Human Adipose Tissue Macrophages: M1 and M2 Cell Surface Markers in Subcutaneous and Omental Depots and after Weight Loss

(2009) Judith Aron-Wisnewsky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome

(2009) Ilkay Tugba Unek et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

(2009) Xia Yang et al.   NATURE GENETICS

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE