Immune deficiency vs. immune excess in inflammatory bowel diseases-STAT3 as a rheo-STAT of intestinal homeostasis

Vedolizumab for Induction and Maintenance of Remission in Ulcerative Colitis

(2015) Mahmoud H. Mosli et al.   INFLAMMATORY BOWEL DISEASES

Atypical Manifestation of LRBA Deficiency with Predominant IBD-like Phenotype

(2015) Nina Kathrin Serwas et al.   INFLAMMATORY BOWEL DISEASES

Noncanonical STAT3 Activation Regulates Excess TGF-β1 and Collagen I Expression in Muscle of Stricturing Crohn’s Disease

(2015) Chao Li et al.   JOURNAL OF IMMUNOLOGY

CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response

(2015) Brian C. Betts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell–iTreg cell balance

(2015) Rajatava Basu et al.   NATURE IMMUNOLOGY

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2

(2015) Maupali Dasgupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Intestinal Epithelial Stat3 Orchestrates Tissue Defense during Gastrointestinal Infection

(2015) Nadine Wittkopf et al.   PLoS One

STAT3 in Epithelial Cells Regulates Inflammation and Tumor Progression to Malignant State in Colon

(2015) Andrew V. Nguyen et al.   NEOPLASIA

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3

(2014) E. M. Haapaniemi et al.   BLOOD

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis

(2014) Sutapa Ray et al.   CELLULAR SIGNALLING

The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease

(2014) Holm H. Uhlig et al.   GASTROENTEROLOGY

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data

(2014) G.-B. Chen et al.   HUMAN MOLECULAR GENETICS

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection

(2014) Xiaohuan Guo et al.   IMMUNITY

PIAS3 suppresses acute graft- versus -host disease by modulating effector T and B cell subsets through inhibition of STAT3 activation

(2014) Sung-Hee Lee et al.   IMMUNOLOGY LETTERS

Comprehensive Intestinal T Helper Cell Profiling Reveals Specific Accumulation of IFN-γ+IL-17+Coproducing CD4+ T Cells in Active Inflammatory Bowel Disease

(2014) Anna-Maria Globig et al.   INFLAMMATORY BOWEL DISEASES

Stat3 Activation in Murine Colitis Induced by Enterotoxigenic Bacteroides fragilis

(2014) Elizabeth C. Wick et al.   INFLAMMATORY BOWEL DISEASES

Pleiotropic functions of TNF-  in the regulation of the intestinal epithelial response to inflammation

(2014) M. Leppkes et al.   INTERNATIONAL IMMUNOLOGY

STAT3 Activation in Th17 and Th22 Cells Controls IL-22–Mediated Epithelial Host Defense during Infectious Colitis

(2014) Ingo Backert et al.   JOURNAL OF IMMUNOLOGY

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

(2014) Sarah E Flanagan et al.   NATURE GENETICS

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

(2014) Lukas Schwab et al.   NATURE MEDICINE

Blau Syndrome, the prototypic auto-inflammatory granulomatous disease

(2014) Carine H Wouters et al.   Pediatric Rheumatology

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Mendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

(2014) Jacinta Bustamante et al.   SEMINARS IN IMMUNOLOGY

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

(2013) Holm H Uhlig   GUT

Deletion of Intestinal Epithelial Cell STAT3 Promotes T-Lymphocyte STAT3 Activation and Chronic Colitis Following Acute Dextran Sodium Sulfate Injury in Mice

(2013) Tara A. Willson et al.   INFLAMMATORY BOWEL DISEASES

Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation–polyendocrinopathy–enteropathy–X-linked–like syndrome

(2013) Gulbu Uzel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727

(2013) Qifang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome

(2013) Daniel Kotlarz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Controlling the frontier: Regulatory T-cells and intestinal homeostasis

(2013) Julia Bollrath et al.   SEMINARS IN IMMUNOLOGY

The ARNT–STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ+CD8αα+ cells

(2013) Kohei Nakajima et al.   Nature Communications

Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces

(2013) Blaise Corthésy   Frontiers in Immunology

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

The development of LTi cells

(2012) Marie Cherrier et al.   CURRENT OPINION IN IMMUNOLOGY

Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency

(2012) Fabian Hauck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation

(2012) Karin R. Engelhardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autosomal Dominant STAT3 Deficiency and Hyper-IgE Syndrome

(2012) Marie-Olivia Chandesris et al.   MEDICINE

Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity

(2012) Shensi Shen et al.   MOLECULAR CELL

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-10–Producing Regulatory B10 Cells Inhibit Intestinal Injury in a Mouse Model

(2011) Koichi Yanaba et al.   AMERICAN JOURNAL OF PATHOLOGY

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

(2011) J R Matthews et al.   CELL DEATH AND DIFFERENTIATION

Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

(2011) Ivan Monteleone et al.   GASTROENTEROLOGY

Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease: Figure 1

(2011) R Somasundaram et al.   GUT

Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis

(2011) K. Leiper et al.   GUT

Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells

(2011) Neil V. Morgan et al.   JOURNAL OF CLINICAL INVESTIGATION

STAT3 Genotypic Variation and Cellular STAT3 Activation and Colon Leukocyte Recruitment in Pediatric Crohn Disease

(2011) Tara A. Willson et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome

(2011) H R Conti et al.   Mucosal Immunology

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

(2011) Feng-Yen Li et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Array-Based Sequence Capture and Next-Generation Sequencing for the Identification of Primary Immunodeficiencies

(2011) S. Ghosh et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Human ITCH E3 Ubiquitin Ligase Deficiency Causes Syndromic Multisystem Autoimmune Disease

(2010) Naomi J. Lohr et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells

(2010) Jean-Marie Ramirez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility

(2010) M C Cénit et al.   GENES AND IMMUNITY

Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease

(2010) Elizabeth A Worthey et al.   GENETICS IN MEDICINE

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

Selective IgA Deficiency

(2010) Leman Yel   JOURNAL OF CLINICAL IMMUNOLOGY

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch–Belgian Cohort

(2009) Rinse K Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America

(2009) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Revisiting Crohn's disease as a primary immunodeficiency of macrophages: Figure 1.

(2009) Jean-Laurent Casanova et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hyperactivated B cells in human inflammatory bowel disease

(2009) Ansu Mammen Noronha et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' disease

(2008) D. E. Fassi et al.   GUT

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Phagocyte dysfunction and inflammatory bowel disease

(2008) Farooq Z. Rahman et al.   INFLAMMATORY BOWEL DISEASES

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Digestive histopathological presentation of IPEX syndrome

(2008) Natacha Patey-Mariaud de Serre et al.   MODERN PATHOLOGY

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

(2008) Andre Franke et al.   NATURE GENETICS

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA