Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation

Resveratrol suppresses pulmonary tumor metastasis by inhibiting platelet-mediated angiogenic responses

(2017) Liwei He et al.   JOURNAL OF SURGICAL RESEARCH

Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective

(2017) Rindert Missiaen et al.   VASCULAR PHARMACOLOGY

Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies – A review

(2017) Ahmed M. Al-Abd et al.   Journal of Advanced Research

Nuclear PKM2 expression, an independent risk factor for ER after curative resection of hepatocellular carcinoma

(2016) Fangtian Fan et al.   BIOMEDICINE & PHARMACOTHERAPY

Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway

(2016) Wei Li et al.   EXPERIMENTAL CELL RESEARCH

PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis

(2016) Ji Liang et al.   Nature Communications

KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi’s sarcoma

(2015) Tao Ma et al.   ANGIOGENESIS

Lifespan and healthspan extension by resveratrol

(2015) Khushwant S. Bhullar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Norcantharidin combined with EGFR-TKIs overcomes HGF-induced resistance to EGFR-TKIs in EGFR mutant lung cancer cells via inhibition of Met/PI3k/Akt pathway

(2015) Hongyan Wu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Endothelial Metabolism Driving Angiogenesis

(2015) Anna Rita Cantelmo et al.   CANCER JOURNAL

The angiogenic responses induced by release of angiogenic proteins from tumor cell-activated platelets are regulated by distinct molecular pathways

(2015) Hongyan Wu et al.   IUBMB LIFE

By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice

(2015) Weiqi Dai et al.   Oncotarget

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma

(2015) Wei-Ren Liu et al.   Oncotarget

PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EGFR Activation

(2014) Fang-Tian Fan et al.   Asian Pacific Journal of Cancer Prevention

A potential novel treatment strategy: inhibition of angiogenesis and inflammation by resveratrol for regression of endometriosis in an experimental rat model

(2014) Pinar Ozcan Cenksoy et al.   GYNECOLOGICAL ENDOCRINOLOGY

Trans-3,4,5,4′-tetramethoxystilbene, a resveratrol analog, potently inhibits angiogenesis in vitro and in vivo

(2013) Liang-ke Chen et al.   ACTA PHARMACOLOGICA SINICA

Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase

(2013) Lilian S. Gomez et al.   BIOCHIMIE

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Incomplete and transitory decrease of glycolysis

(2013) Sandra Schoors et al.   CELL CYCLE

Role of Endothelial Cell Metabolism in Vessel Sprouting

(2013) Katrien De Bock et al.   Cell Metabolism

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Resveratrol has inhibitory effects on the hypoxia-induced inflammation and angiogenesis in human adipose tissue in vitro

(2013) Karina B. Cullberg et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1  Activation

(2013) K.-H. Jung et al.   JOURNAL OF NUCLEAR MEDICINE

α-santalol inhibits the angiogenesis and growth of human prostate tumor growth by targeting vascular endothelial growth factor receptor 2-mediated AKT/mTOR/P70S6K signaling pathway

(2013) Sarita Saraswati et al.   Molecular Cancer

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Resveratrol Inhibits Cancer Cell Metabolism by Down Regulating Pyruvate Kinase M2 via Inhibition of Mammalian Target of Rapamycin

(2012) Mohd Askandar Iqbal et al.   PLoS One

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Anti-Angiogenic Effects of Resveratrol on Cerebral Angiogenesis

(2011) Pei-Lin Chen et al.   CURRENT NEUROVASCULAR RESEARCH

Resveratrol Induces p53-independent, X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Bax Protein Oligomerization on Mitochondria to Initiate CytochromecRelease and Caspase Activation

(2011) Raghu Gogada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect

(2011) Minsuh Seo et al.   PLoS One

Resveratrol Regulates Pathologic Angiogenesis by a Eukaryotic Elongation Factor-2 Kinase-Regulated Pathway

(2010) Aslam A. Khan et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-oxidant Effects of Resveratrol on Mice with DSS-induced Ulcerative Colitis

(2010) Jun Yao et al.   ARCHIVES OF MEDICAL RESEARCH

Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: Pivotal roles of NF-κB and MAPK

(2009) Ok-Hwa Kang et al.   PHARMACOLOGICAL RESEARCH

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

(2008) B. Clem et al.   MOLECULAR CANCER THERAPEUTICS