Article
Endocrinology & Metabolism
Joao Victor Salgado, Miguel Angelo Goes, Natalino Salgado Filho
Summary: The global nephrology community acknowledges the increasing burden of kidney disease and emphasizes on early diagnosis, understanding of disease progression, and development of new therapeutic interventions. FGF21 is considered a key regulator of lipid, glucose, and energy metabolism, as well as stress responses. While promising results have been shown with FGF21 analogs in metabolic disease, its exact role in kidney function remains poorly understood.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Transplantation
Wei Ling Lau, Yongen Chang, Nosratola D. Vaziri
Summary: The normal gut microbiome plays a crucial role in regulating host immunity and enterocyte metabolism. Chronic kidney disease can lead to dysbiosis and intestinal inflammation. Shifts in bacterial populations in the gut may contribute to the production of metabolites that affect the host immune system.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Chang-Sheng Sheng, Dan Wang, Jiangzi Yuan, Yi Cheng, Siming Sun, Yulin Yang, Ya Miao, Weiming Wang, Jingyan Tian, Zachary T. Bloomgarden
Summary: Non-albuminuric chronic kidney disease (CKD) is associated with increased risk of all-cause and cardiovascular mortality when eGFR is less than 45 mL/min/1.73 m(2). Increased albuminuria is associated with higher risk of primary outcome and all-cause mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Ruifeng Wang, Jingjing Zhang, Dandan Li, Guiling Liu, Yuqin Fu, Qing Li, Lei Zhang, Long Qian, Li Hao, Yiping Wang, David C. H. Harris, Deguang Wang, Qi Cao
Summary: This study investigated the frequency of circulating ILC subsets in various chronic kidney diseases (CKD) and found an increase in these subsets correlated with certain disease features. This suggests a possible role for ILCs in CKD.
CLINICAL IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Cong Li, Honghua Yu, Zhuoting Zhu, Xianwen Shang, Yu Huang, Charumathi Sabanayagam, Xiaohong Yang, Lei Liu
Summary: This study aimed to explore the association between blood pressure and the risk of diabetic microvascular complications (DMCs). The results showed that participants with higher systolic blood pressure had a lower risk of DMCs, and hypertension defined by the 2017 ACC/AHA guidelines may not have a significant impact on the incidence of DMCs compared to the JNC 7 criteria.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Urology & Nephrology
Sameera Gunawardena, Maleesha Dayaratne, Harshima Wijesinghe, Eranga Wijewickrama
Summary: Thirteen studies were included in the scoping review. Interstitial fibrosis was the predominant lesion in all studies. Although no characteristic histopathological feature could be found in CKDu-Sri Lanka or Mesoamerican nephropathy, there are noticeable differences between these two groups in the frequency and severity of the glomerular and tubulointerstitial changes.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Hyunwoo Kim, Miyeon Kim, Hwa-Young Lee, Ho-Young Park, Hyunjhung Jhun, Soohyun Kim
Summary: Diabetic nephropathy is a significant microvascular complication in diabetic patients, with current treatment options insufficient to prevent its progression. Recent studies suggest DN is an inflammatory disease, with immune cells potentially playing a role in its development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Khurrum Shahzad, Sameen Fatima, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Hamzah Khawaja, Saira Ambreen, Ahmed Elwakiel, Nora Kloeting, Matthias Blueher, Peter P. Nawroth, Peter R. Mertens, Sven Michel, Frank Jaschinski, Richard Klar, Berend Isermann
Summary: The study demonstrates that an ASO-based approach reducing CHOP expression can ameliorate DKD in mice, providing renal protection on top of ACE inhibition. Inhibition of CHOP not only improves glomerular damage, but also tubular damage. ASO therapies are a potential new approach to target maladaptive ER stress signaling and improve DKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Transplantation
Sok Cin Tye, Petra Denig, Hiddo J. L. Heerspink
Summary: The increasing prevalence of end-stage kidney disease worldwide is closely linked to the rising number of people with diabetes. Early diagnosis of chronic kidney disease in diabetic patients is crucial for slowing down kidney function decline and preventing ESKD. Tailoring individual treatment is necessary due to variation in CKD progression and treatment response among diabetic patients. Biomarker-based approaches show promise in identifying high-risk patients and guiding targeted therapy, potentially leading to a shift towards personalized medicine in diabetic kidney disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Cell Biology
Jiali Wang, Yongda Lin, Xiutian Chen, Yiping Liu, Tianbiao Zhou
Summary: Chronic kidney disease has significant impact on public health and requires more effective treatment tools. Mesenchymal stem cells show potential as a new tool for CKD treatment, with the ability to improve renal function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Nutrition & Dietetics
Guido Gembillo, Luca Visconti, Alfio Edoardo Giuffrida, Vincenzo Labbozzetta, Luigi Peritore, Antonella Lipari, Vincenzo Calabrese, Giorgina Barbara Piccoli, Massimo Torreggiani, Rossella Siligato, Domenico Santoro
Summary: Zinc plays a potential role in kidney and body homeostasis in diabetic patients and those at a high risk of developing diabetic kidney disease by counteracting diabetes-related risk factors and reducing oxidative stress levels, which can slow down the progression of kidney disease.
Review
Physiology
Xue Zhou, Yuefeng Zhang, Ning Wang
Summary: Chronic kidney disease is a progressive and incurable disease that can lead to various complications and it is crucial to prevent and treat it at an early stage. FGF21, as an important regulatory factor in cellular functions, may have a potential relationship with kidney diseases, but further studies are needed to explore its biological role in this context.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
David S. H. Bell, Janet B. B. McGill, Terri Jerkins
Summary: Patients with type 2 diabetes are at high risk of developing heart failure and chronic kidney disease. The focus has been on reducing the risk of cardiovascular disease through controlling blood glucose, lipids, and blood pressure, but even well-controlled patients can still develop heart failure or kidney disease. The use of additional treatments, such as sodium-glucose co-transporter-2 inhibitors and non-steroidal mineralocorticoid receptor antagonists, is now recommended to promote cardiorenal protection.
DIABETES OBESITY & METABOLISM
(2023)
Article
Urology & Nephrology
Nicholas L. S. Roberts, Jean L. Pierre, Vanessa Rouzier, Rodney Sufra, Stefano St-Preux, Lily D. Yan, Miranda Metz, Adrienne Clermont, Alexandra Apollon, Shalom Sabwa, Marie M. Deschamps, Justin R. Kingery, Robert Peck, Daniel Fitzgerald, Jean W. Pape, Sri Lekha Tummalapalli, Margaret L. McNairy
Summary: This study characterized the epidemiology of CKD in a population-based cohort in urban Haiti, and found that CKD was highly associated with diabetes and hypertension. It also highlighted the low proportion of CKD patients receiving guideline-recommended treatment, emphasizing the need for strengthening clinical management and nephrology care health infrastructure in Haiti.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Cell Biology
Che-Hao Tseng, Kavya M. Shah, I-Jen Chiu, Li-Li Hsiao
Summary: Diabetic kidney disease is one of the most prevalent complications of type 2 diabetes mellitus, causing a significant burden on patients worldwide. Recent studies have highlighted the relationship between autophagy and diabetic kidney disease, suggesting autophagy as a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Yong-Hui Mao, Qing-Hua Weng, Leng-Nan Xu, Xiang-Yu Li, Ban Zhao, Ying Sun, Jing-Jing Nie, Ji-Hong Hu, Qi Zhou, Li-Qun Zhang, Jian Guo, Ming-Zhang Zuo, Sadayoshi Ito, Jian-Ping Cai
FREE RADICAL RESEARCH
(2017)
Editorial Material
Peripheral Vascular Disease
Fumitoshi Satoh, Hironobu Sasano, Yuto Yamazaki, Sadayoshi Ito
Article
Peripheral Vascular Disease
Ryo Morimoto, Yoshikiyo Ono, Yuta Tezuka, Masataka Kudo, Sachiko Yamamoto, Toshiaki Arai, Celso E. Gomez-Sanchez, Hironobu Sasano, Sadayoshi Ito, Fumitoshi Satoh
Article
Medicine, General & Internal
Eikan Mishima, Kazuichi Maruyama, Toru Nakazawa, Takaaki Abe, Sadayoshi Ito
Article
Peripheral Vascular Disease
Eikan Mishima, Takehiro Suzuki, Kazumasa Seiji, Yasutoshi Akiyama, Hideki Ota, Junichiro Hashimoto, Kei Takase, Takaaki Abe, Sadayoshi Ito
JOURNAL OF CLINICAL HYPERTENSION
(2017)
Article
Biochemistry & Molecular Biology
Hiroki Shimada, Naotaka Kogure, Erika Noro, Masataka Kudo, Kaori Sugawara, Ikuko Sato, Kyoko Shimizu, Makoto Kobayashi, Dai Suzuki, Rehana Parvin, Takako Saito-Ito, Akira Uruno, Akiko Saito-Hakoda, William E. Rainey, Sadayoshi Ito, Atsushi Yokoyama, Akira Sugawara
Article
Medicine, General & Internal
Tetsuro Matsuhashi, Takeya Sato, Shin-ichiro Kanno, Takehiro Suzuki, Akihiro Matsuo, Yuki Oba, Motoi Kikusato, Emi Ogasawara, Tai Kudo, Kosuke Suzuki, Osamu Ohara, Hiroko Shimbo, Fumika Nanto, Hiroaki Yamaguchi, Daisuke Saigusa, Yasuno Mukaiyama, Akiko Watabe, Koichi Kikuchi, Hisato Shima, Eikan Mishima, Yasutoshi Akiyama, Yoshitsugu Oikawa, Hsin-Jung Ho, Yukako Akiyama, Chitose Suzuki, Mitsugu Uematsu, Masaki Ogata, Naonori Kumagai, Masaaki Toyomizu, Atsushi Hozawa, Nariyasu Mano, Yuji Owada, Setsuya Aiba, Teruyuki Yanagisawa, Yoshihisa Tomioka, Shigeo Kure, Sadayoshi Ito, Kazuto Nakada, Ken-ichiro Hayashi, Hitoshi Osaka, Takaaki Abe
Article
Multidisciplinary Sciences
Hisato Shima, Kensuke Sasaki, Takehiro Suzuki, Chikahisa Mukawa, Ten Obara, Yuki Oba, Akihiro Matsuo, Takayasu Kobayashi, Eikan Mishima, Shun Watanabe, Yasutoshi Akiyama, Koichi Kikuchi, Tetsuro Matsuhashi, Yoshitsugu Oikawa, Fumika Nanto, Yukako Akiyama, Hsin-Jung Ho, Chitose Suzuki, Daisuke Saigusa, Atsushi Masamune, Yoshihisa Tomioka, Takao Masaki, Sadayoshi Ito, Ken-ichiro Hayashi, Takaaki Abe
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Emiko Sato, Yukako Tsunokuni, Manami Kaneko, Daisuke Saigusa, Ritsumi Saito, Shuichi Shimma, Akiyo Sekimoto, Yoshiko Kawana, Yuji Oe, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Hidekazu Shirai, Emiko Sato, Akiyo Sekimoto, Taeko Uchida, Yuji Oe, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Medicine, Research & Experimental
Sadayoshi Ito, Yasuyuki Okuda, Kotaro Sugimoto
Summary: This study examined factors associated with the antihypertensive effects of esaxerenone and the incidence of serum potassium elevation in patients with hypertension. Results showed that factors such as sex, weight, hypertension duration, prior antihypertensive treatment, plasma aldosterone concentration, urinary albumin-to-creatinine ratio, and smoking were associated with changes in blood pressure. Factors significantly associated with serum potassium elevation included baseline serum potassium, renal function, urinary albumin-to-creatinine ratio, blood pressure, and hypertension grade. The study concluded that esaxerenone is effective for patients with various backgrounds, but careful management is needed for those at risk of elevated serum potassium.
ADVANCES IN THERAPY
(2023)
Article
Urology & Nephrology
Kaori Narumi, Eikan Mishima, Yukako Akiyama, Tetsuro Matsuhashi, Takashi Nakamichi, Kiyomi Kisu, Shuhei Nishiyama, Hajime Ikenouchi, Akio Kikuchi, Rumiko Izumi, Mariko Miyazaki, Takaaki Abe, Hiroshi Sato, Sadayoshi Ito
Article
Urology & Nephrology
Toshiki Iwai, Mariko Miyazaki, Gen Yamada, Masaaki Nakayama, Tae Yamamoto, Michihiro Satoh, Hiroshi Sato, Sadayoshi Ito
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Sakiko Hayashi, Yuji Oe, Tomofumi Fushima, Emiko Sato, Hiroshi Sato, Sadayoshi Ito, Nobuyuki Takahashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Physiology
Tomofumi Fushima, Akiyo Sekimoto, Yuji Oe, Emiko Sato, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2017)