Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?

Invariant NKT Cells Regulate Experimental Autoimmune Encephalomyelitis and Infiltrate the Central Nervous System in a CD1d-Independent Manner

(2014) L. T. Mars et al.   JOURNAL OF IMMUNOLOGY

Primary immunodeficiency associated with defects in CD1 and CD1-restricted T cells

(2012) Sebastian Zeissig et al.   Annals of the New York Academy of Sciences

Lipid-Antigen Presentation by CD1d+ B Cells Is Essential for the Maintenance of Invariant Natural Killer T Cells

(2012) Anneleen Bosma et al.   IMMUNITY

CD4+ Type II NKT Cells Mediate ICOS and Programmed Death-1-Dependent Regulation of Type 1 Diabetes

(2012) N. Kadri et al.   JOURNAL OF IMMUNOLOGY

Autoimmunity's next top models

(2012) Hartmut Wekerle et al.   NATURE MEDICINE

Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis

(2011) Asako Chiba et al.   ARTHRITIS AND RHEUMATISM

Structure-guided design of an invariant natural killer T cell agonist for optimum protection from type 1 diabetes in non-obese diabetic mice

(2011) H. J. Blumenfeld et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes

(2011) Yannick Simoni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Group 1 CD1-restricted T cells take center stage

(2011) Mary H. Young et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis

(2011) Yusei Miyazaki et al.   INTERNATIONAL IMMUNOLOGY

CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans

(2011) Anne G. Kasmar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Invariant NKT Cells Producing IL-4 or IL-10, But Not IFN- , Inhibit the Th1 Response in Experimental Autoimmune Encephalomyelitis, Whereas None of These Cells Inhibits the Th17 Response

(2011) S. J. Oh et al.   JOURNAL OF IMMUNOLOGY

A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen–recognition properties

(2011) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

(2011) Patrick J Brennan et al.   NATURE IMMUNOLOGY

Distinct and Overlapping Effector Functions of Expanded Human CD4+, CD8α+ and CD4-CD8α- Invariant Natural Killer T Cells

(2011) Vincent O'Reilly et al.   PLoS One

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

An α-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes

(2010) D. Ly et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mechanism of regulation of autoimmunity by iNKT cells

(2010) Jan Novak et al.   CYTOKINE

Invariant natural killer T cells: Linking inflammation and neovascularization in human atherosclerosis

(2010) Emmanouil Kyriakakis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells

(2010) Claudia de Lalla et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of immunological disorders by invariant Vα19-Jα33 TCR-bearing cells

(2010) Michio Shimamura et al.   IMMUNOBIOLOGY

A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state

(2010) Ghazal Zekavat et al.   IMMUNOGENETICS

Early activation of invariant natural killer T cells in a rheumatoid arthritis model and application to disease treatment

(2010) Aurore Miellot-Gafsou et al.   IMMUNOLOGY

Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells

(2010) Subramanya Hegde et al.   IMMUNOLOGY

Natural killer T cells are important in the pathogenesis of asthma: The many pathways to asthma

(2010) Dale T. Umetsu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Natural killer T cells are not the predominant T cell in asthma and likely modulate, not cause, asthma

(2010) Seddon Y. Thomas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice

(2010) Yawei Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Invariant NKT cells limit activation of autoreactive CD1d-positive B cells

(2010) Fredrik Wermeling et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire

(2010) Annemieke de Jong et al.   NATURE IMMUNOLOGY

Raising the NKT cell family

(2010) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a  -linked self-glycolipid

(2010) P. Arrenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NKT Cell Subsets Mediate Differential Proatherogenic Effects in ApoE −/− Mice

(2009) Kelly To et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human γδ T cell Recognition of lipid A is predominately presented by CD1b or CD1c on dendritic cells

(2009) Yongchun Cui et al.   Biology Direct

Rituximab treatment overcomes reduction of regulatory iNKT cells in patients with rheumatoid arthritis

(2009) Véronique Parietti et al.   CLINICAL IMMUNOLOGY

CD1-restricted adaptive immune responses toMycobacteriain human group 1 CD1 transgenic mice

(2009) Kyrie Felio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular and immunogenic features of myelin lipids: incitants or modulators of multiple sclerosis?

(2009) M Podbielska et al.   Multiple Sclerosis Journal

Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer

(2008) D. H. Chang et al.   BLOOD

Liver Autoimmunity Triggered by Microbial Activation of Natural Killer T Cells

(2008) Jochen Mattner et al.   Cell Host & Microbe

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

(2008) Shouxiong Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity

(2008) Asuka Terashima et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of Keratinocyte Protein Kinase Cζ in Psoriasis Plaques

(2008) Yuming Zhao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population

(2008) J. M. Coquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural killer T cells and innate immune B cells from lupus-prone NZB/W mice interact to generate IgM and IgG autoantibodies

(2007) Tsuyoshi Takahashi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY