CD27+B cells from a subgroup of common variable immunodeficiency patients are less sensitive to apoptosis rescue regardless of interleukin-21 signalling

Common variable immunodeficiency (CVID): exploring the multiple dimensions of a heterogeneous disease

(2012) Ulrich Salzer et al.   Annals of the New York Academy of Sciences

Common variable immunodeficiency - an update

(2012) Ulrich Salzer et al.   ARTHRITIS RESEARCH & THERAPY

IL-21 is the primary common   chain-binding cytokine required for human B-cell differentiation in vivo

(2011) M. Recher et al.   BLOOD

B cells from common variable immunodeficiency patients fail to differentiate to antibody secreting cells in response to TLR9 ligand (CpG-ODN) or anti-CD40+IL21

(2011) Antonio Clemente et al.   CELLULAR IMMUNOLOGY

Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help

(2011) Magdalena Hagn et al.   IMMUNOLOGY AND CELL BIOLOGY

Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis

(2011) Julien van Grevenynghe et al.   JOURNAL OF CLINICAL INVESTIGATION

Update on the hyper immunoglobulin M syndromes

(2010) E. Graham Davies et al.   BRITISH JOURNAL OF HAEMATOLOGY

CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency

(2010) Menno C. van Zelm et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell receptor triggering sensitizes human B cells to TRAIL-induced apoptosis

(2010) Andre Ortlieb Guerreiro-Cacais et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency

(2009) S. Borte et al.   BLOOD

IL-21 and T follicular helper cells

(2009) R. Spolski et al.   INTERNATIONAL IMMUNOLOGY

CD20 deficiency in humans results in impaired T cell–independent antibody responses

(2009) Taco W. Kuijpers et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of IL-21 in regulating B-cell function in health and disease

(2008) Rachel Ettinger et al.   IMMUNOLOGICAL REVIEWS