Article
Biochemistry & Molecular Biology
Svitlana Skoroplyas, Ondrej Vasicek, Michaela Chorvatova, Petra Dad'ova, Katerina Lehka, Lukas Kubala
Summary: Pseurotin D has the potential to inhibit DTH reaction through inhibiting the activation and differentiation of both T cells and B cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Oncology
Ines Roger, Paula Montero, Martin Perez-Leal, Javier Milara, Julio Cortijo
Summary: The clinical practice faces the problem of delayed-type hypersensitivity (DTH) caused by various drugs, especially in antineoplastic treatments. DTH reactions can range from mild self-limiting maculopapular eruptions to severe Stevens-Johnson Syndrome, resulting in worsened patient quality of life. Apart from impacting patients, these reactions also lead to economic losses due to drug withdrawal and high hospitalization costs. However, there is currently no standard in vitro or in vivo method to evaluate the sensitizing potential of drugs in preclinical studies. This review aims to comprehensively evaluate in vitro and in vivo methods for detecting DTH and testing antineoplastic hypersensitivity reactions caused by different antineoplastic families.
Article
Chemistry, Medicinal
Ines Roger, Paula Montero, Antonio Garcia, Javier Milara, Pilar Ribera, Jose Alejandro Perez-Fidalgo, Julio Cortijo
Summary: Delayed-type hypersensitivity (DTH) is a common reaction caused by various drugs, especially antineoplastic drugs, which may affect patients' quality of life. However, there is currently a lack of standardized methods for evaluating the sensitizing potential of drugs in the preclinical phase. This study aimed to adapt in vitro techniques to predict the sensitizing potential of antineoplastic agents and discovered that inhibition of the VEGFR1 pathway may be a potential trigger of DTH.
Article
Mathematics, Applied
Rasa Smidtaite, Loreta Saunoriene, Minvydas Ragulskis
Summary: This paper presents an algorithm for detecting lag synchronization from time series data. The algorithm can handle multi-variate time series data and is capable of detecting lag synchronization between chaotic signals contaminated by noise. Additionally, the algorithm can be used as a feature extraction algorithm for detecting cyclic alternating patterns in sleep.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2023)
Review
Biochemistry & Molecular Biology
Quentin Lecocq, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot
Summary: Blockade of immune checkpoints has advanced immuno-oncology, but not all patients benefit. Research on alternative pathways like LAG-3 shows promise as therapeutic targets. Monitoring LAG-3 expression in tumors is crucial for ongoing clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Martin Perez-Santos, Maricruz Anaya-Ruiz, Luis Villafana-Diaz, Gabriela Sanchez Esgua
Summary: This article discusses the development strategy of LAG-3 inhibitors and their related clinical trials and patents. The future research challenge is the design and development of peptides and small molecules that can inhibit the function of LAG-3.
EXPERT OPINION ON DRUG DISCOVERY
(2022)
Article
Chemistry, Medicinal
Katarzyna Nazimek, Eugenio Bustos-Moran, Noelia Blas-Rus, Bernadeta Nowak, Justyna Toton-Zuranska, Michal T. Seweryn, Pawel Wolkow, Olga Woznicka, Rafal Szatanek, Maciej Siedlar, Philip W. Askenase, Francisco Sanchez-Madrid, Krzysztof Bryniarski
Summary: This study demonstrates that suppressor T cell-derived EVs carrying miRNA-150 can antigen-specifically downregulate mouse delayed-type hypersensitivity. Pre-incubation with antigen-specific antibodies enhances the inhibitory effect of macrophage-released EVs on effector T cells. The specific binding of EVs to MHC class II-expressing EVs promotes their aggregation and significantly increases their suppressive activity in vivo, potentially offering therapeutic benefits.
Article
Immunology
Alycia P. Fratzke, Anthony E. Gregory, Erin J. van Schaik, James E. Samuel
Summary: Q-VAX (R), a vaccine for Q fever, provides long-term protection but can cause reactions in sensitized individuals, limiting its use outside Australia. Studying different mouse strains revealed that the reactions to C. burnetii whole cell vaccine are consistent with a Th1 delayed-type hypersensitivity response.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Feng Xu, Hongting Zhang, Hao Xiao, Juan Meng
Summary: This case report highlights a delayed-type IV allergic reaction to furazolidone in a patient receiving treatment for H.pylori infection. Clinicians should be aware of the potential for hypersensitivity to furazolidone.
CONTACT DERMATITIS
(2023)
Article
Allergy
Heena Mehta, Carolyn Jack, Catherine Maari, Etienne Saint-Cyr Proulx, Robert Bissonnette, Francisco Ramirez-Valle, Marika Sarfati
Summary: The potential benefit of inducing delayed-type hypersensitivity (DTH) reaction in healthy volunteers as experimental models to study skin inflammatory disorders was reported. This study investigated the immunophenotype of skin T cells and their modulation by oral drugs in a local DTH reaction.
Article
Pharmacology & Pharmacy
Joanne Ellis, Daniel J. B. Marks, Naren Srinivasan, Christine Barrett, Thomas G. Hopkins, Anna Richards, Rainard Fuhr, Muna Albayaty, Martin Coenen, Lia Liefaard, Karen Leavens, Katherine L. Nevin, Shuo Tang, Stephen A. Hughes, Lea Fortunato, Ken Edwards, Yi Cui, Rabia Anselm, Christopher J. Delves, Emilie Charles, Maria Feeney, Thomas M. Webb, Sara J. Brett, Tim S. Schmidt, John Stone, Caroline O. S. Savage, Nicolas Wisniacki, Ruth M. Tarzi
Summary: GSK2831781, a novel afucosylated humanized IgG1 monoclonal antibody that depletes LAG-3 expressing cells, showed promising pharmacological activity in a phase I/Ib clinical study for psoriasis. The treatment led to significant reduction in LAG-3(+) and CD3(+) T-cell counts in psoriasis plaques, along with modulation of proinflammatory and epithelial barrier integrity genes. Psoriasis disease activity improved with GSK2831781, supporting further investigation in T-cell-mediated inflammatory diseases.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Dermatology
Joseph Han, Scott Stratman, Jade N. Young, Dina Poplausky, Shayan Owji, Yen Luu, Yeriel Estrada, Joel Correa da Rosa, James G. Krueger, Nicholas Gulati
Summary: Diphencyprone (DPCP) causes a delayed-type hypersensitivity reaction when applied topically, and is used clinically for various conditions. In this study, proteomic analysis of healthy volunteers showed upregulation of immune cell activation, tissue remodeling, antineoplastic markers, and Th1 axis markers following DPCP application. Negative regulators of immune function were also upregulated, which may explain the therapeutic benefits in autoimmune conditions. The study also revealed a transient Th2 response followed by Th1 polarization. Overall, DPCP induces a complex and evolving immunological response.
JOURNAL OF DERMATOLOGY
(2023)
Article
Automation & Control Systems
Hideki Sano
Summary: This paper analyzes the stability of heat exchangers with delayed boundary feedback and shows that the upper bound of the feedback gain to ensure closed-loop stability under the presence of any time lag is solved by computing the H8-norm of a complex function. This means that each closed-loop system with admissible feedback gain is robust with respect to any time lag.
Article
Immunology
Picabo Binette, Mahelat Tesfamariam, Diane Cockrell, Robert A. Heinzen, Crystal Richards, Carl Shaia, Carrie Mae Long
Summary: This study investigates the immunologic mechanisms of delayed-type hypersensitivity (DTH) response to Q fever vaccine. Using a murine model, it is found that female mice display a more robust early-phase DTH response compared to male mice and other strains. The study also suggests that sex is a primary factor influencing the magnitude and composition of the ensuing response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Tomasz Klaus, Sameer Deshmukh
Summary: pH-responsive antibodies show strong treatment potential as programmable engineered biologic drugs, targeting the acidified tumor microenvironment with improved spatial persistence and reduced toxicities. They can also be used in CAR-T engineering and improving drug delivery to the brain.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Editorial Material
Gastroenterology & Hepatology
Nicolas Poirier, Bernard Vanhove
Article
Genetics & Heredity
Marit K. H. van der Wiel, Gaby G. M. Doxiadis, N. de Groot, N. Otting, N. G. de Groot, N. Poirier, G. Blancho, R. E. Bontrop
Article
Medicine, Research & Experimental
Benjamin K. Watkins, Victor Tkachev, Scott N. Furlan, Daniel J. Hunt, Kayla Betz, Alison Yu, Melanie Brown, Nicolas Poirier, Hengqi Betty Zheng, Agne Taraseviciute, Lucrezia Colonna, Caroline Mary, Gilles Blancho, Jean-Paul Soulillou, Angela Panoskaltsis-Mortari, Prachi Sharma, Anapatricia Garcia, Elizabeth Strobert, Kelly Hamby, Aneesah Garrett, Taylor Deane, Bruce R. Blazar, Bernard Vanhove, Leslie S. Kean
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Multidisciplinary Sciences
Lyssia Belarif, Caroline Mary, Lola Jacquemont, Hoa Le Mai, Richard Danger, Jeremy Hervouet, David Minault, Virginie Thepenier, Veronique Nerriere-Daguin, Elisabeth Nguyen, Sabrina Pengam, Eric Largy, Arnaud Delobel, Bernard Martinet, Stephanie Le Bas-Bernardet, Sophie Brouard, Jean-Paul Soulillou, Nicolas Degauque, Gilles Blancho, Bernard Vanhove, Nicolas Poirier
NATURE COMMUNICATIONS
(2018)
Article
Medicine, Research & Experimental
Lyssia Belarif, Richard Danger, Laetitia Kermarrec, Veronique Nerriere-Daguin, Sabrina Pengam, Tony Durand, Caroline Mary, Elise Kerdreux, Vanessa Gauttier, Aneta Kucik, Virginie Thepenier, Jerome C. Martin, Christie Chang, Adeeb Rahman, Nina Salabert-Le Guen, Cecile Braudeau, Ahmed Abidi, Gregoire David, Florent Malard, Celine Takoudju, Bernard Martinet, Nathalie Gerard, Isabelle Neveu, Michel Neunlist, Emmanuel Coron, Thomas T. MacDonald, Pierre Desreumaux, Hoa-Le Mai, Stephanie Le Bas-Bernardet, Jean-Francois Mosnier, Miriam Merad, Regis Josien, Sophie Brouard, Jean-Paul Soulillou, Gilles Blancho, Arnaud Bourreille, Philippe Naveilhan, Bernard Vanhove, Nicolas Poirier
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Review
Immunology
Bernard Vanhove, Nicolas Poirier, Jean-Paul Soulillou, Gilles Blancho
Article
Surgery
Sabrina Pengam, Justine Durand, Claire Usal, Vanessa Gauttier, Nahzli Dilek, Bernard Martinet, Veronique Daguin, Caroline Mary, Virginie Thepenier, Geraldine Teppaz, Karine Renaudin, Gilles Blancho, Bernard Vanhove, Nicolas Poirier
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Surgery
Hoa Le Mai, Thi Van Ha Nguyen, Julien Branchereau, Nicolas Poirier, Karine Renaudin, Caroline Mary, Lyssia Belarif, David Minault, Jeremy Hervouet, Stephanie Le Bas-Berdardet, Jean-Paul Soulillou, Bernard Vanhove, Gilles Blancho, Sophie Brouard
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Medicine, Research & Experimental
Vanessa Gauttier, Sabrina Pengam, Justine Durand, Kevin Biteau, Caroline Mary, Aurore Morello, Melanie Neel, Georgia Porto, Geraldine Teppaz, Virginie Thepenier, Richard Danger, Nicolas Vince, Emmanuelle Wilhelm, Isabelle Girault, Riad Abes, Catherine Ruiz, Charlene Trilleaud, Kerry Ralph, E. Sergio Trombetta, Alexandra Garcia, Virginie Vignard, Bernard Martinet, Alexandre Glemain, Sarah Bruneau, Fabienne Haspot, Safa Dehmani, Pierre Duplouye, Masayuki Miyasaka, Nathalie Labarriere, David Laplaud, Stephanie Le Bas-Bernardet, Christophe Blanquart, Veronique Catros, Pierre-Antoine Gouraud, Isabelle Archambeaud, Helene Auble, Sylvie Metairie, Jean-Francois Mosnier, Dominique Costantini, Gilles Blancho, Sophie Conchon, Bernard Vanhove, Nicolas Poirier
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Rheumatology
Elodie Riviere, Juliette Pascaud, Alexandre Virone, Anastasia Dupre, Bineta Ly, Audrey Paoletti, Raphaele Seror, Nicolas Tchitchek, Michael Mingueneau, Nikaia Smith, Darragh Duffy, Lydie Cassard, Nathalie Chaput, Sabrina Pengam, Vanessa Gauttier, Nicolas Poirier, Xavier Mariette, Gaetane Nocturne
Summary: This study indicates the presence of an IL-7/IFN gamma amplification loop involving SGECs and T cells in primary SS. IL-7 was secreted by SGECs stimulated with type I or type II IFN and activated T cells that secreted IFN gamma. An anti-IL-7R antibody decreased the IFN signature in T cells in primary SS and could be a therapeutic option.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Immunology
Bernard Vanhove, Odile Duvaux, Juliette Rousse, Pierre-Joseph Royer, Gwenaelle Evanno, Carine Ciron, Elsa Lheriteau, Laurent Vacher, Nadine Gervois, Romain Oger, Yannick Jacques, Sophie Conchon, Apolline Salama, Roberto Duchi, Irina Lagutina, Andrea Perota, Philippe Delahaut, Matthieu Ledure, Melody Paulus, Ray T. So, Chris Ka-Pun Mok, Roberto Bruzzone, Marc Bouillet, Sophie Brouard, Emanuele Cozzi, Cesare Galli, Dominique Blanchard, Jean-Marie Bach, Jean-Paul Soulillou
Summary: Heterologous polyclonal antibodies offer a potential alternative in COVID-19 treatment, but may trigger human xenogeneic antibody responses. A recent study introduced a method to produce glyco-humanized polyclonal antibodies that showed promising results in neutralizing the virus, highlighting the importance of further clinical assessment.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Patrick Reichenbach, Greta Maria Paola Giordano Attianese, Khaoula Ouchen, Elisabetta Cribioli, Melanie Triboulet, Sarah Ash, Margaux Saillard, Romain Vuillefroy de Silly, George Coukos, Melita Irving
Summary: This study reports the design and production of a lentiviral vector that incorporates two functionally independent promoters, allowing for the expression of a tumour-directed receptor and inducible gene in T cells. The vector enables the delivery of various genes to human T cells, improving the safety and efficacy of T-cell therapies.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Immunology
Bernard Vanhove, Stephane Marot, Ray T. So, Benjamin Gaborit, Gwenaelle Evanno, Isabelle Malet, Guillaume Lafrogne, Edwige Mevel, Carine Ciron, Pierre-Joseph Royer, Elsa Lheriteau, Francois Raffi, Roberto Bruzzone, Chris Ka Pun Mok, Odile Duvaux, Anne-Genevieve Marcelin, Vincent Calvez
Summary: Amino acid substitutions and deletions in the Spike protein of SARS-CoV-2 variants can reduce the effectiveness of monoclonal antibodies, while polyclonal antibodies like XAV-19 show potential for maintaining neutralization capacities by targeting multiple epitopes. XAV-19, a swine glyco-humanized polyclonal neutralizing antibody, demonstrates potent neutralization capacities against different variants of SARS-CoV-2, covering various epitopes on the RBD region. Ongoing clinical trials are evaluating the efficacy and safety of XAV-19 in COVID-19 patients with promising results.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Gael Boivin, Pierre-Benoit Ancey, Romain Vuillefroy de Silly, Pradeep Kalambaden, Caroline Contat, Benoit Petit, Jonathan Ollivier, Jean Bourhis, Etienne Meylan, Marie-Catherine Vozenin
Summary: The study reveals that incomplete depletion of neutrophils using anti-Ly6G antibodies can promote their oxidative activity and resistance to depletion. Combining anti-Ly6G with radiation therapy leads to long-lasting tumor regression in certain models, with the combination of G-CSF and anti-TNF alpha affecting this effect.
Article
Cell Biology
Lyssia Belarif, Bernard Vanhove, Nicolas Poirier