A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor

Rapid manufacturing of non-activated potent CAR T cells

(2022) Saba Ghassemi et al.   Nature Biomedical Engineering

High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA

(2022) Soyoung A. Oh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NY-ESO-1-specific redirected T cells with endogenous TCR knockdown mediate tumor response and cytokine release syndrome

(2022) Mikiya Ishihara et al.   Journal for ImmunoTherapy of Cancer

High-performance multiplex drug-gated CAR circuits

(2022) Hui-Shan Li et al.   CANCER CELL

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

(2022) Brian R. Shy et al.   NATURE BIOTECHNOLOGY

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

(2021) Max Jan et al.   Science Translational Medicine

A nonviral, nonintegrating DNA nanovector platform for the safe, rapid, and persistent manufacture of recombinant T cells

(2021) Matthias Bozza et al.   Science Advances

Advances in the Development and the Applications of Nonviral, Episomal Vectors for Gene Therapy

(2021) Grace Elizabeth Mulia et al.   HUMAN GENE THERAPY

An isoform of Dicer protects mammalian stem cells against multiple RNA viruses

(2021) Enzo Z. Poirier et al.   SCIENCE

Better living through chemistry: CRISPR/Cas engineered T cells for cancer immunotherapy

(2021) Nils Wellhausen et al.   CURRENT OPINION IN IMMUNOLOGY

Choosing the Right Tool for Genetic Engineering: Clinical Lessons from Chimeric Antigen Receptor-T Cells

(2021) Melita Irving et al.   HUMAN GENE THERAPY

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

(2020) Greta Giordano-Attianese et al.   NATURE BIOTECHNOLOGY

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

Design and Characterization of an “All-in-One” Lentiviral Vector System Combining Constitutive Anti-GD2 CAR Expression and Inducible Cytokines

(2020) Katharina Zimmermann et al.   Cancers

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Optimization of T-cell Receptor–Modified T Cells for Cancer Therapy

(2020) Dylan J. Drakes et al.   Cancer Immunology Research

Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives

(2020) Ulrich T. Hacker et al.   Cancers

Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies

(2020) Jingwen Si et al.   CANCER CELL

All systems go: converging synthetic biology and combinatorial treatment for CAR-T cell therapy

(2020) Evripidis Lanitis et al.   CURRENT OPINION IN BIOTECHNOLOGY

TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals

(2020) Francesco Manfredi et al.   Frontiers in Immunology

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function

(2020) Yun Wang et al.   PLoS One

Safety and Tolerability of Adoptive Cell Therapy in Cancer

(2019) Benita Wolf et al.   DRUG SAFETY

Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3–Targeted Chimeric Antigen Receptor–Engineered T Cells in Hepatocellular Carcinoma

(2019) Ying Liu et al.   JOURNAL OF IMMUNOLOGY

The Potential for microRNA Therapeutics and Clinical Research

(2019) Johora Hanna et al.   Frontiers in Genetics

De novo design of programmable inducible promoters

(2019) Xiangyang Liu et al.   NUCLEIC ACIDS RESEARCH

Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity

(2019) Carolina B. Ferreira et al.   Molecular Therapy-Methods & Clinical Development

Clinical use of lentiviral vectors

(2018) Michael C. Milone et al.   LEUKEMIA

Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 c259 T Cells in Synovial Sarcoma

(2018) Sandra P. D'Angelo et al.   Cancer Discovery

NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives

(2018) Remy Thomas et al.   Frontiers in Immunology

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

(2018) Sarwish Rafiq et al.   NATURE BIOTECHNOLOGY

Robust Enhancement of Lentivirus Production by Promoter Activation

(2018) Naoto Suzuki et al.   Scientific Reports

Engineering Natural Killer Cells for Cancer Immunotherapy

(2017) Katayoun Rezvani et al.   MOLECULAR THERAPY

CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

(2017) Markus Chmielewski et al.   Cell Reports

Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don’t Forget the Fuel

(2017) Melita Irving et al.   Frontiers in Immunology

Armored CAR T-cells: utilizing cytokines and pro-inflammatory ligands to enhance CAR T-cell anti-tumour efficacy

(2016) Oladapo O. Yeku et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

Tet-On Systems For Doxycycline-inducible Gene Expression

(2016) Atze T. Das et al.   CURRENT GENE THERAPY

Viral Vectors: The Road to Reducing Genotoxicity

(2016) Rhiannon M. David et al.   TOXICOLOGICAL SCIENCES

Production of lentiviral vectors

(2016) Otto-Wilhelm Merten et al.   Molecular Therapy-Methods & Clinical Development

Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma

(2015) L. Zhang et al.   CLINICAL CANCER RESEARCH

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Antiviral RNA Interference in Mammalian Cells

(2013) P. V. Maillard et al.   SCIENCE

Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

(2013) A. Aiuti et al.   SCIENCE

Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

(2013) A. Biffi et al.   SCIENCE

Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies

(2013) G. L. Beatty et al.   Cancer Immunology Research

CAR T cells transform to trucks: chimeric antigen receptor–redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer

(2012) Markus Chmielewski et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Local Delivery of lnterleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice

(2012) D. Chinnasamy et al.   CLINICAL CANCER RESEARCH

Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+T Cell Responsiveness

(2012) Melita Irving et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells

(2012) Monika Gullerova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex role of microRNAs in HTLV-1 infections

(2012) Gavin C. Sampey et al.   Frontiers in Genetics

IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

(2011) M. Chmielewski et al.   CANCER RESEARCH

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

(2011) S. A. Rosenberg et al.   CLINICAL CANCER RESEARCH

Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment

(2011) Ling Zhang et al.   MOLECULAR THERAPY

Lentiviral Vectors in Gene Therapy: Their Current Status and Future Potential

(2010) David Escors et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

(2010) V Hoyos et al.   LEUKEMIA

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

(2010) Marina Cavazzana-Calvo et al.   NATURE

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors

(2009) T Maetzig et al.   GENE THERAPY

Independent and high-level dual-gene expression in adult stem-progenitor cells from a single lentiviral vector

(2009) J Tian et al.   GENE THERAPY

Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor

(2009) James N. Kochenderfer et al.   JOURNAL OF IMMUNOTHERAPY

Transcriptional Termination Enhances Protein Expression in Human Cells

(2009) Steven West et al.   MOLECULAR CELL

Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

(2009) Robert H Kutner et al.   Nature Protocols

Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct

(2008) J A Curtin et al.   GENE THERAPY

Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette

(2008) Matthias Leisegang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

(2008) Ryan L Boudreau et al.   MOLECULAR THERAPY

Titers of HIV-based Vectors Encoding shRNAs are Reduced by a Dicer-dependent Mechanism

(2007) Ananthalakshmi Poluri et al.   MOLECULAR THERAPY