Cancer systems biology: a network modeling perspective

Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model

(2009) Zhihui Wang et al.   BIOINFORMATICS

Computational Analysis of Dynamical Responses to the Intrinsic Pathway of Programmed Cell Death

(2009) Tongli Zhang et al.   BIOPHYSICAL JOURNAL

Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting

(2009) Amina A Qutub et al.   BMC Systems Biology

Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance

(2009) Özgür Sahin et al.   BMC Systems Biology

RAS Mutations Affect Tumor Necrosis Factor-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects

(2009) P. K. Kreeger et al.   CANCER RESEARCH

Cancer Genome Sequencing--An Interim Analysis

(2009) E. J. Fox et al.   CANCER RESEARCH

Systems Biology Reveals New Strategies for Personalizing Cancer Medicine and Confirms the Role of PTEN in Resistance to Trastuzumab

(2009) D. Faratian et al.   CANCER RESEARCH

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts

(2009) Nils Blüthgen et al.   FEBS Journal

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

A pharmacologically based multiscale mathematical model of angiogenesis and its use in investigating the efficacy of a new cancer treatment strategy

(2009) Frédérique Billy et al.   JOURNAL OF THEORETICAL BIOLOGY

A Genomic Strategy to Elucidate Modules of Oncogenic Pathway Signaling Networks

(2009) Jeffrey T. Chang et al.   MOLECULAR CELL

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Distinct mechanisms act in concert to mediate cell cycle arrest

(2009) Jared E. Toettcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases

(2009) C. S. H. Tan et al.   Science Signaling

Integrating Proteomic, Transcriptional, and Interactome Data Reveals Hidden Components of Signaling and Regulatory Networks

(2009) S.-s. C. Huang et al.   Science Signaling

Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor-PI3K Axis

(2009) B. Schoeberl et al.   Science Signaling

The Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data

(2009) Regina Samaga et al.   PLoS Computational Biology

Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling

(2009) Bree B. Aldridge et al.   PLoS Computational Biology

Integrated analysis of breast cancer cell lines reveals unique signaling pathways

(2009) Laura M Heiser et al.   GENOME BIOLOGY

Beyond the Oncogene Paradigm: Understanding Complexity in Cancerogenesis

(2008) M. Bizzarri et al.   ACTA BIOTHEORETICA

Dependence of Invadopodia Function on Collagen Fiber Spacing and Cross-Linking: Computational Modeling and Experimental Evidence

(2008) Heiko Enderling et al.   BIOPHYSICAL JOURNAL

Explaining oscillations and variability in the p53-Mdm2 system

(2008) Carole J Proctor et al.   BMC Systems Biology

Revealing Targeted Therapy for Human Cancer by Gene Module Maps

(2008) D. J. Wong et al.   CANCER RESEARCH

Mechanisms of malignant progression

(2008) R. A. Weinberg   CARCINOGENESIS

Can Systems Biology Understand Pathway Activation? Gene Expression Signatures as Surrogate Markers for Understanding the Complexity of Pathway Activation

(2008) Hiraku Itadani et al.   CURRENT GENOMICS

Quantitative modeling perspectives on the ErbB system of cell regulatory processes

(2008) Matthew J. Lazzara et al.   EXPERIMENTAL CELL RESEARCH

Network medicine

(2008) Tony Pawson et al.   FEBS LETTERS

Multiscale modelling and nonlinear simulation of vascular tumour growth

(2008) Paul Macklin et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Targeting the Human Cancer Pathway Protein Interaction Network by Structural Genomics

(2008) Yuanpeng Janet Huang et al.   MOLECULAR & CELLULAR PROTEOMICS

Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

(2008) Eric Batchelor et al.   MOLECULAR CELL

Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells

(2008) John G. Albeck et al.   MOLECULAR CELL

Multipathway Model Enables Prediction of Kinase Inhibitor Cross-Talk Effects on Migration of Her2-Overexpressing Mammary Epithelial Cells

(2008) N. Kumar et al.   MOLECULAR PHARMACOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers

(2008) R. J. Leary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening

(2008) J. M. Silva et al.   SCIENCE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE