Growth Factors, Nutrient Signaling, and Cardiovascular Aging

Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity

(2016) Manlio Vinciguerra et al.   Aging-US

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

Surprising sirtuin crosstalk in the heart

(2016) Thaddeus T. Schug et al.   Aging-US

SirT1 brings stemness closer to cancer and aging

(2016) Vincenzo Calvanese et al.   Aging-US

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart

(2011) Manlio Vinciguerra et al.   AGING CELL

IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines

(2011) Maria Paola Santini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia

(2011) Cecilia M. Prêle et al.   CARDIOVASCULAR PATHOLOGY

Caloric Restriction Primes Mitochondria for Ischemic Stress by Deacetylating Specific Mitochondrial Proteins of the Electron Transport Chain

(2011) Ken Shinmura et al.   CIRCULATION RESEARCH

Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb

(2011) Kimberley C. W. Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heart regeneration

(2011) Michael A. Laflamme et al.   NATURE

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

(2010) Catarina Rippe et al.   AGING CELL

At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways

(2010) Gian Paolo Fadini et al.   AGING CELL

Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

(2010) C. Lee et al.   CANCER RESEARCH

Caloric restriction delays cardiac ageing in rats: role of mitochondria

(2010) Bernd Niemann et al.   CARDIOVASCULAR RESEARCH

Cardiomyogenesis in the Adult Human Heart

(2010) Jan Kajstura et al.   CIRCULATION RESEARCH

SirT1 in muscle physiology and disease: lessons from mouse models

(2010) M. Vinciguerra et al.   Disease Models & Mechanisms

Minireview: Mechano-Growth Factor: A Putative Product of IGF-I Gene Expression Involved in Tissue Repair and Regeneration

(2010) Ronald W. Matheny et al.   ENDOCRINOLOGY

Drosophila as a model to study cardiac aging

(2010) Mayuko Nishimura et al.   EXPERIMENTAL GERONTOLOGY

Calorie Restriction Prevents Hypertension and Cardiac Hypertrophy in the Spontaneously Hypertensive Rat

(2010) Vernon W. Dolinsky et al.   HYPERTENSION

The molecular basis by which dietary restricted feeding reduces mitochondrial reactive oxygen species generation

(2010) C.E. Ash et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative Stress

(2010) Dao-Fu Dai et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Lipid homeostasis, lipotoxicity and the metabolic syndrome

(2009) Roger H. Unger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cardiac Progenitor Cells and Biotinylated Insulin-Like Growth Factor-1 Nanofibers Improve Endogenous and Exogenous Myocardial Regeneration After Infarction

(2009) M. Elena Padin-Iruegas et al.   CIRCULATION

The fabulous destiny of the Drosophila heart

(2009) Caroline Medioni et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Contribution of Glucose Tolerance and Gender to Cardiac Adiposity

(2009) Patricia Iozzo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipokine Profile and Urinary Albumin Excretion in Isolated Growth Hormone Deficiency

(2009) Carla R. P. Oliveira et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Attenuation of Age-Related Metabolic Dysfunction in Mice With a Targeted Disruption of the C  Subunit of Protein Kinase A

(2009) L. C. Enns et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Long-Lived Ames Dwarf Mice Are Resistant to Chemical Stressors

(2009) Alex F. Bokov et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Insulin-like growth factor-I E peptides: implications for ageing skeletal muscle

(2009) Cristina P. Velloso et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

(2008) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction

(2008) Jun Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism

Local Activation or Implantation of Cardiac Progenitor Cells Rescues Scarred Infarcted Myocardium Improving Cardiac Function

(2008) Marcello Rota et al.   CIRCULATION RESEARCH

Activation of Cardiac Progenitor Cells Reverses the Failing Heart Senescent Phenotype and Prolongs Lifespan

(2008) Arantxa Gonzalez et al.   CIRCULATION RESEARCH

FoxO transcription factors in the maintenance of cellular homeostasis during aging

(2008) Dervis AM Salih et al.   CURRENT OPINION IN CELL BIOLOGY

IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Gαq interaction and protein kinase C-α/CaMKII activation in H9c2 cardiomyoblast cells

(2008) Chun-Hsien Chu et al.   JOURNAL OF ENDOCRINOLOGY

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA