Modeling Inherited Cardiac Disorders

The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes

(2014) Anton Mihic et al.   BIOMATERIALS

Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype

(2013) Christine Y. Ivashchenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hepatogenesis of murine induced pluripotent stem cells in 3D micro-cavitary hydrogel system for liver regeneration

(2013) Ting Ting Lau et al.   BIOMATERIALS

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells

(2013) Feng Lan et al.   Cell Stem Cell

Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

(2013) E. G. Navarrete et al.   CIRCULATION

Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

(2013) Ping Liang et al.   CIRCULATION

In Vivo Differentiation of Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2013) Tao Yu et al.   CIRCULATION JOURNAL

Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture

(2013) Tsukasa Kamakura et al.   CIRCULATION JOURNAL

Arrhythmia Phenotype During Fetal Life Suggests Long-QT Syndrome Genotype

(2013) Bettina F. Cuneo et al.   Circulation-Arrhythmia and Electrophysiology

Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel DES mutation identified by whole exome sequencing

(2013) Hung-Fat Tse et al.   HUMAN MOLECULAR GENETICS

Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells

(2013) Dongrui Ma et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Patient-Specific Stem Cells and Cardiovascular Drug Discovery

(2013) Nicholas M. Mordwinkin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

(2013) Changsung Kim et al.   NATURE

Electrical Stimulation Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells

(2013) Yau-Chi Chan et al.   Journal of Cardiovascular Translational Research

Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K+channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells

(2012) J Jehle et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hypertrophic cardiomyopathy: diagnosis, risk stratification and treatment

(2012) D. L. Jacoby et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Disease characterization using LQTS-specific induced pluripotent stem cells

(2012) Toru Egashira et al.   CARDIOVASCULAR RESEARCH

Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming

(2012) Paul W. Burridge et al.   Cell Stem Cell

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Shugo Tohyama et al.   Cell Stem Cell

Genetic testing in heritable cardiac arrhythmia syndromes

(2012) John R. Giudicessi et al.   CURRENT OPINION IN CARDIOLOGY

Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich's ataxia

(2012) A. Hick et al.   Disease Models & Mechanisms

Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy

(2012) Dongrui Ma et al.   EUROPEAN HEART JOURNAL

Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets

(2012) Shin Kadota et al.   EUROPEAN HEART JOURNAL

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

(2012) Cecile Terrenoire et al.   JOURNAL OF GENERAL PHYSIOLOGY

Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia With Patient-Specific Human-Induced Pluripotent Stem Cells

(2012) Ilanit Itzhaki et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes

(2012) S.R. Braam et al.   Stem Cell Research

A Review of Human Pluripotent Stem Cell-Derived Cardiomyocytes for High-Throughput Drug Discovery, Cardiotoxicity Screening, and Publication Standards

(2012) Nicholas M. Mordwinkin et al.   Journal of Cardiovascular Translational Research

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells

(2011) Azra Fatima et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

(2011) A. L. Lahti et al.   Disease Models & Mechanisms

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

(2011) Christian B. Jung et al.   EMBO Molecular Medicine

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation

(2011) Elena Matsa et al.   EUROPEAN HEART JOURNAL

HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies

(2011) Michael J. Ackerman et al.   HEART RHYTHM

Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification

(2011) Hsiang-Po Huang et al.   HUMAN MOLECULAR GENETICS

Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation

(2011) Atara Novak et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mortality in Friedreich Ataxia

(2011) Amy Y. Tsou et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

(2011) Masayuki Yazawa et al.   NATURE

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Induction and Enhancement of Cardiac Cell Differentiation from Mouse and Human Induced Pluripotent Stem Cells with Cyclosporin-A

(2011) Masataka Fujiwara et al.   PLoS One

Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations

(2011) J.D. Cohen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Generation of HIV-1 Resistant and Functional Macrophages From Hematopoietic Stem Cell–derived Induced Pluripotent Stem Cells

(2010) Amal Kambal et al.   MOLECULAR THERAPY

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

(2010) Xonia Carvajal-Vergara et al.   NATURE

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms and clinical management of inherited channelopathies: Long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome

(2009) Elizabeth S. Kaufman   HEART RHYTHM

Protective effect of KCNH2 single nucleotide polymorphism K897T in LQTS families and identification of novel KCNQ1 and KCNH2mutations

(2008) Xianqin Zhang et al.   BMC Medical Genetics

Repolarization Reserve

(2008) Dan M. Roden   CIRCULATION

Therapeutic Strategies for Long-QT Syndrome

(2008) Yanfei Ruan et al.   Circulation-Arrhythmia and Electrophysiology

SCN5A overlap syndromes: no end to disease complexity?

(2008) C. A. Remme et al.   EUROPACE

Pompe's disease

(2008) Ans T van der Ploeg et al.   LANCET

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE