Insulin Regulation of Myocardial Autophagy

Autophagy and mitophagy in diabetic cardiomyopathy

(2015) Satoru Kobayashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cardiomyocyte glycophagy is regulated by insulin and exposure to high extracellular glucose

(2014) Kimberley M. Mellor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of autophagy and mitophagy by nutrient availability and acetylation

(2014) Bradley R. Webster et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Insulin Inhibits Cardiac Contractility by Inducing a Gi-Biased  2-Adrenergic Signaling in Hearts

(2014) Q. Fu et al.   DIABETES

GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure

(2014) Renata O. Pereira et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Insulin Receptor Substrates Are Essential for the Bioenergetic and Hypertrophic Response of the Heart to Exercise Training

(2014) C. Riehle et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors

(2013) Christian Rask-Madsen et al.   Cell Metabolism

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Glucose-Insulin-Potassium Revived

(2013) Alexandra N. Grossman et al.   CIRCULATION

Cardiac Metabolism in Heart Failure

(2013) Torsten Doenst et al.   CIRCULATION RESEARCH

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF B-Opa-1 Signaling Pathway

(2013) V. Parra et al.   DIABETES

Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling

(2013) S. Paula-Gomes et al.   HORMONE AND METABOLIC RESEARCH

Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes

(2013) Xianmin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart

(2013) Christian Riehle et al.   JOURNAL OF CLINICAL INVESTIGATION

Heme Oxygenase-1 Prevents Cardiac Dysfunction in Streptozotocin-Diabetic Mice by Reducing Inflammation, Oxidative Stress, Apoptosis and Enhancing Autophagy

(2013) Yanli Zhao et al.   PLoS One

Cardiomyocyte health: adapting to metabolic changes through autophagy

(2013) Dieter A. Kubli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inducible Overexpression of GLUT1 Prevents Mitochondrial Dysfunction and Attenuates Structural Remodeling in Pressure Overload but Does Not Prevent Left Ventricular Dysfunction

(2013) Renata O. Pereira et al.   Journal of the American Heart Association

Insulin Resistance: Metabolic Mechanisms and Consequences in the Heart

(2012) E. Dale Abel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia

(2012) Sebastiano Sciarretta et al.   CIRCULATION

Mechanisms of Lipotoxicity in the Cardiovascular System

(2012) Adam R. Wende et al.   CURRENT HYPERTENSION REPORTS

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

(2012) Q.-J. Zhang et al.   DIABETES

Genetic loss of insulin receptors worsens cardiac efficiency in diabetes

(2012) Heiko Bugger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac PI3K-Akt Impairs Insulin-Stimulated Glucose Uptake Independent of mTORC1 and GLUT4 Translocation

(2012) Yi Zhu et al.   MOLECULAR ENDOCRINOLOGY

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy

(2011) Yinan Hua et al.   BASIC RESEARCH IN CARDIOLOGY

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

(2011) Rodrigo Troncoso et al.   CARDIOVASCULAR RESEARCH

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice

(2011) Pankaj Shende et al.   CIRCULATION

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents

(2010) Ippei Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Functional Significance and Morphological Characterization of Starvation-Induced Autophagy in the Adult Heart

(2009) Hiromitsu Kanamori et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy maintains cardiac function in the starved adult

(2009) Genzou Takemura et al.   Autophagy

Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding

(2009) Jordan J. Wright et al.   CARDIOVASCULAR RESEARCH

Suppression of Phosphoinositide 3-Kinase Prevents Cardiac Aging in Mice

(2009) Yasutaka Inuzuka et al.   CIRCULATION

Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart

(2009) Sihem Boudina et al.   CIRCULATION

Contribution of Insulin and Akt1 Signaling to Endothelial Nitric Oxide Synthase in the Regulation of Endothelial Function and Blood Pressure

(2009) J. David Symons et al.   CIRCULATION RESEARCH

Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction

(2009) Stuart A. Cook et al.   EUROPEAN HEART JOURNAL

Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction

(2009) Sandra Sena et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy

(2009) Hiroyuki Ikeda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Macroautophagy and its role in nutrient homeostasis

(2009) Martha H Stipanuk   NUTRITION REVIEWS

Autophagy in the cardiovascular system

(2008) Guido R.Y. De Meyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease

(2008) R. W. Schwenk et al.   CARDIOVASCULAR RESEARCH

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy

(2008) Jaetaek Kim et al.   MOLECULAR ENDOCRINOLOGY

Cardiac Remodeling in Obesity

(2008) E. Dale Abel et al.   PHYSIOLOGICAL REVIEWS

Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways

(2008) Haim Werner et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY