Peroxisome-mitochondria interplay and disease

New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes

(2015) Fátima Camões et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation

(2015) Annelies Peeters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Peroxisome-localized hepatitis Bx protein increases the invasion property of hepatocellular carcinoma cells

(2014) Jae-Min Han et al.   ARCHIVES OF VIROLOGY

Loss of AMP-activated protein kinase in X-linked adrenoleukodystrophy patient-derived fibroblasts and lymphocytes

(2014) Jaspreet Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of peroxisomal lipid metabolism: The role of acyl-CoA and coenzyme A metabolizing enzymes

(2014) Mary C. Hunt et al.   BIOCHIMIE

How the mitochondrion was shaped by radical differences in substrates

(2014) Dave Speijer   BIOESSAYS

Evolutionary considerations on the origin of peroxisomes from the endoplasmic reticulum, and their relationships with mitochondria

(2014) Toni Gabaldón   CELLULAR AND MOLECULAR LIFE SCIENCES

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1

(2014) Juan Carlos Corona et al.   EXPERIMENTAL NEUROLOGY

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication

(2014) Lukas Bahati Tanner et al.   JOURNAL OF LIPID RESEARCH

C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma

(2014) Stefan Salcher et al.   Molecular Cancer

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

(2014) Charlotte Odendall et al.   NATURE IMMUNOLOGY

The Pestivirus N Terminal Protease Npro Redistributes to Mitochondria and Peroxisomes Suggesting New Sites for Regulation of IRF3 by Npro

(2014) Matthew Jefferson et al.   PLoS One

The Intracellular Bacteria Chlamydia Hijack Peroxisomes and Utilize Their Enzymatic Capacity to Produce Bacteria-Specific Phospholipids

(2014) Gaelle Boncompain et al.   PLoS One

Oxaliplatin Neurotoxicity Involves Peroxisome Alterations. PPARγ Agonism as Preventive Pharmacological Approach

(2014) Matteo Zanardelli et al.   PLoS One

Hepatitis C virus, mitochondria and auto/mitophagy: Exploiting a host defense mechanism

(2014) Vitalba Ruggieri   WORLD JOURNAL OF GASTROENTEROLOGY

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

(2014) Koji Yamano et al.   eLife

Overexpression of human fatty acid transport protein 2/very long chain acyl-CoA synthetase 1 (FATP2/Acsvl1) reveals distinct patterns of trafficking of exogenous fatty acids

(2013) Elaina M. Melton et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient

(2013) Sara Violante et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A role for the human peroxisomal half-transporter ABCD3 in the oxidation of dicarboxylic acids

(2013) Carlo W.T. van Roermund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondrial dysfunction and oxidative damage cooperatively fuel axonal degeneration in X-linked adrenoleukodystrophy

(2013) Stéphane Fourcade et al.   BIOCHIMIE

Peroxisomal metabolism and oxidative stress

(2013) Marcus Nordgren et al.   BIOCHIMIE

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein

(2013) Chris Fröhlich et al.   EMBO JOURNAL

Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission

(2013) Nina Huber et al.   EMBO REPORTS

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

(2013) Bo Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

(2013) J. López-Erauskin et al.   HUMAN MOLECULAR GENETICS

Impaired Very Long-chain Acyl-CoA β-Oxidation in Human X-linked Adrenoleukodystrophy Fibroblasts Is a Direct Consequence of ABCD1 Transporter Dysfunction

(2013) Christoph Wiesinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Proteins MiD49 and MiD51 Can Act Independently of Mff and Fis1 in Drp1 Recruitment and Are Specific for Mitochondrial Fission

(2013) Catherine S. Palmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Redox Proteome

(2013) Young-Mi Go et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

(2013) Hongmei Li et al.   NATURE CELL BIOLOGY

Self-Interaction of Human Pex11pβ during Peroxisomal Growth and Division

(2013) Nina A. Bonekamp et al.   PLoS One

The Proteome of Human Liver Peroxisomes: Identification of Five New Peroxisomal Constituents by a Label-Free Quantitative Proteomics Survey

(2013) Thomas Gronemeyer et al.   PLoS One

Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids

(2013) Carine De Marcos Lousa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

PEX5, the Shuttling Import Receptor for Peroxisomal Matrix Proteins, Is a Redox-Sensitive Protein

(2013) Oksana Apanasets et al.   TRAFFIC

The Peroxisomal Enzyme L-PBE Is Required to Prevent the Dietary Toxicity of Medium-Chain Fatty Acids

(2013) Jun Ding et al.   Cell Reports

Mff functions with Pex11p  and DLP1 in peroxisomal fission

(2013) A. Itoyama et al.   Biology Open

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Peroxisomes, cell senescence, and rates of aging

(2012) Courtney R. Giordano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fission and proliferation of peroxisomes

(2012) M. Schrader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Peroxisomal ABC transporters: Structure, function and role in disease

(2012) Masashi Morita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The relevance of the non-canonical PTS1 of peroxisomal catalase

(2012) Chris Williams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Signaling Organelles of the Innate Immune System

(2012) Jonathan C. Kagan   CELL

Biology and Therapeutic Applications of Peroxisome Proliferator- Activated Receptors

(2012) Maria P. Menendez-Gutierrez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Defects in Mitochondrial and Peroxisomal β-Oxidation Influence Virulence in the Maize Pathogen Ustilago maydis

(2012) Matthias Kretschmer et al.   EUKARYOTIC CELL

Peroxisomal and Mitochondrial β-Oxidation Pathways Influence the Virulence of the Pathogenic Fungus Cryptococcus neoformans

(2012) Matthias Kretschmer et al.   EUKARYOTIC CELL

The peroxisome: an update on mysteries

(2012) Markus Islinger et al.   HISTOCHEMISTRY AND CELL BIOLOGY

PEX11 proteins attract Mff and human Fis1 to coordinate peroxisomal fission

(2012) J. Koch et al.   JOURNAL OF CELL SCIENCE

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

(2012) Kenta Onoue et al.   JOURNAL OF CELL SCIENCE

Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids

(2012) Sander M. Houten et al.   JOURNAL OF LIPID RESEARCH

First PEX11β patient extends spectrum of peroxisomal biogenesis disorder phenotypes: Table 1

(2012) S Thoms et al.   JOURNAL OF MEDICAL GENETICS

Genomic analysis of mitochondrial diseases in a consanguineous population reveals novel candidate disease genes

(2012) Hanan E Shamseldin et al.   JOURNAL OF MEDICAL GENETICS

A novel defect of peroxisome division due to a homozygous non-sense mutation in thePEX11βgene

(2012) Merel S Ebberink et al.   JOURNAL OF MEDICAL GENETICS

Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

(2012) Astrid Bottelbergs et al.   Journal of Neuroinflammation

The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

(2012) Elizabeth Gray et al.   Journal of Neuroinflammation

Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi

(2012) Johannes Freitag et al.   NATURE

Evidence of oxidative stress in very long chain fatty acid – Treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins

(2012) M. Baarine et al.   NEUROSCIENCE

Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary-Structured RNA

(2012) Randi K. Berg et al.   PLoS One

LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Complex Interactions of Mammalian Peroxisomes Without Exchange of Matrix or Membrane Marker Proteins

(2012) Nina A. Bonekamp et al.   TRAFFIC

The essential adaptors of innate immune signaling

(2012) Huihui Chen et al.   Protein & Cell

Effects of peroxisomal catalase inhibition on mitochondrial function

(2012) Paul A. Walton   Frontiers in Physiology

The role of hepatitis B virus X protein is related to its differential intracellular localization

(2011) J. Ma et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Oxidative Damage Compromises Energy Metabolism in the Axonal Degeneration Mouse Model of X-Adrenoleukodystrophy

(2011) Jorge Galino et al.   ANTIOXIDANTS & REDOX SIGNALING

Phytanic acid metabolism in health and disease

(2011) Ronald J.A. Wanders et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Transfer of metabolites across the peroxisomal membrane

(2011) Vasily D. Antonenkov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Viruses exploiting peroxisomes

(2011) Paul B Lazarow   CURRENT OPINION IN MICROBIOLOGY

A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders

(2011) F. D. Mast et al.   Disease Models & Mechanisms

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

(2011) Oksana Ivashchenko et al.   MOLECULAR BIOLOGY OF THE CELL

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

(2011) Sabrina Diano et al.   NATURE MEDICINE

Incidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-α on oligodendrocytes and astrocytes

(2011) Mauhamad Baarine et al.   NEUROTOXICOLOGY

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

(2011) S. M. Horner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Quality Control of Mitochondrial Proteostasis

(2011) M. J. Baker et al.   Cold Spring Harbor Perspectives in Biology

The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue

(2011) Lee D Roberts et al.   GENOME BIOLOGY

FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase

(2010) Alaric Falcon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Peroxisomes, lipid metabolism and lipotoxicity

(2010) R.J.A. Wanders et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation

(2010) Carlo W.T. van Roermund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without it

(2010) Dave Speijer   BIOESSAYS

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

(2010) M. Elsner et al.   DIABETES

Membrane curvature during peroxisome fission requires Pex11

(2010) Łukasz Opaliński et al.   EMBO JOURNAL

Dynamin-like protein 1 at the Golgi complex: A novel component of the sorting/targeting machinery en route to the plasma membrane

(2010) Nina A. Bonekamp et al.   EXPERIMENTAL CELL RESEARCH

Lack of phylogenetic support for a supposed actinobacterial origin of peroxisomes

(2010) Toni Gabaldón et al.   GENE

A Lethalde NovoMutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division

(2010) Chuang-Rung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Pex11p -mediated growth and division of mammalian peroxisomes follows a maturation pathway

(2010) H. K. Delille et al.   JOURNAL OF CELL SCIENCE

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

(2010) Sander Michel Houten et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism

(2010) Paul P. Van Veldhoven   JOURNAL OF LIPID RESEARCH

Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon

(2010) M. Kumar et al.   JOURNAL OF VIROLOGY

Identification and characterization of new long chain Acyl-CoA dehydrogenases

(2010) Miao He et al.   MOLECULAR GENETICS AND METABOLISM

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional coactivator PGC-1  promotes peroxisomal remodeling and biogenesis

(2010) A. Bagattin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisomes Are Oxidative Organelles

(2009) Vasily D. Antonenkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Biogenesis of peroxisomes and mitochondria: linked by division

(2009) Hannah K. Delille et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Management and outcome in 75 individuals with long-chain fatty acid oxidation defects: results from a workshop

(2009) U. Spiekerkoetter et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells

(2009) David Sebastián et al.   JOURNAL OF LIPID RESEARCH

Peroxisomes from the Heavy Mitochondrial Fraction: Isolation by Zonal Free Flow Electrophoresis and Quantitative Mass Spectrometrical Characterization

(2009) Markus Islinger et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance

(2009) Axel Niemann et al.   NEUROBIOLOGY OF DISEASE

Diversity and dispersal of a ubiquitous protein family: acyl-CoA dehydrogenases

(2009) Yao-Qing Shen et al.   NUCLEIC ACIDS RESEARCH

Peroxule extension over ER-defined paths constitutes a rapid subcellular response to hydroxyl stress

(2009) Alison M. Sinclair et al.   PLANT JOURNAL

Ectopic Catalase Expression in Mitochondria by Adeno-Associated Virus Enhances Exercise Performance in Mice

(2009) Dejia Li et al.   PLoS One

Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases RadioresistanceIn VitroandIn Vivo

(2009) Michael W. Epperly et al.   RADIATION RESEARCH

Peroxisome Dynamics in Cultured Mammalian Cells

(2009) Sofie J. Huybrechts et al.   TRAFFIC

Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells

(2008) David Saggerson   Annual Review of Nutrition

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Short- and medium-chain carnitine acyltransferases and acyl-CoA thioesterases in mouse provide complementary systems for transport of β-oxidation products out of peroxisomes

(2008) M. A. K. Westin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cargo-Selected Transport from the Mitochondria to Peroxisomes Is Mediated by Vesicular Carriers

(2008) Margaret Neuspiel et al.   CURRENT BIOLOGY

The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters

(2008) Carlo W. T. van Roermund et al.   FASEB JOURNAL

Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture

(2008) S. Hein et al.   HUMAN MOLECULAR GENETICS

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

(2008) S. Fourcade et al.   HUMAN MOLECULAR GENETICS

PPARs as therapeutic targets for correction of inborn mitochondrial fatty acid oxidation disorders

(2008) F. Djouadi et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondria

(2008) F. Camões et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Progeric effects of catalase inactivation in human cells

(2008) Jay I. Koepke et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial Fatty-Acid Oxidation Disorders

(2008) Michelle Kompare et al.   Seminars in Pediatric Neurology