Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes

Histone modification mapping in human brain reveals aberrant expression of histone H3 lysine 79 dimethylation in neural tube defects

(2013) Qin Zhang et al.   NEUROBIOLOGY OF DISEASE

Dot1-Dependent Histone H3K79 Methylation Promotes Activation of the Mek1 Meiotic Checkpoint Effector Kinase by Regulating the Hop1 Adaptor

(2013) David Ontoso et al.   PLoS Genetics

A synaptonemal complex-derived mechanism for meiotic segregation precedes the evolutionary loss of homology between sex chromosomes in arvicolid mammals

(2012) Roberto de la Fuente et al.   CHROMOSOMA

Inactivation or non-reactivation: what accounts better for the silence of sex chromosomes during mammalian male meiosis?

(2012) Jesús Page et al.   CHROMOSOMA

Human Histone H3K79 Methyltransferase DOT1L Methyltransferase Binds Actively Transcribing RNA Polymerase II to Regulate Gene Expression

(2012) Seung-Kyoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Structure–Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L

(2012) Justin L. Anglin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spp1, a Member of the Set1 Complex, Promotes Meiotic DSB Formation in Promoters by Tethering Histone H3K4 Methylation Sites to Chromosome Axes

(2012) Vérane Sommermeyer et al.   MOLECULAR CELL

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

(2012) M. C. Castano Betancourt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The COMPASS Subunit Spp1 Links Histone Methylation to Initiation of Meiotic Recombination

(2012) L. Acquaviva et al.   SCIENCE

Structures of human nucleosomes containing major histone H3 variants

(2011) Hiroaki Tachiwana et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Interplay between modifications of chromatin and meiotic recombination hotspots

(2011) Elsa Brachet et al.   BIOLOGY OF THE CELL

Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation

(2011) S. Y. Jo et al.   BLOOD

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

Progressive methylation of ageing histones by Dot1 functions as a timer

(2011) Dirk De Vos et al.   EMBO REPORTS

DOT1L regulates dystrophin expression and is critical for cardiac function

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

The diverse functions of Dot1 and H3K79 methylation

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

Deficiency of H3K79 Histone Methyltransferase Dot1-like Protein (DOT1L) Inhibits Cell Proliferation

(2011) Wootae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies

(2011) Yuan Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome-wide analysis reveals novel molecular features of mouse recombination hotspots

(2011) Fatima Smagulova et al.   NATURE

Distinct Properties of the XY Pseudoautosomal Region Crucial for Male Meiosis

(2011) L. Kauppi et al.   SCIENCE

Checkpoint mechanisms: the puppet masters of meiotic prophase

(2011) Amy J. MacQueen et al.   TRENDS IN CELL BIOLOGY

Mouse PRDM9 DNA-Binding Specificity Determines Sites of Histone H3 Lysine 4 Trimethylation for Initiation of Meiotic Recombination

(2011) Corinne Grey et al.   PLOS BIOLOGY

Early mammalian erythropoiesis requires the Dot1L methyltransferase

(2010) Y. Feng et al.   BLOOD

Epigenetic Regulation of Pericentromeric Heterochromatin during Mammalian Meiosis

(2010) A.M. Khalil et al.   CYTOGENETIC AND GENOME RESEARCH

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

(2010) M. Mohan et al.   GENES & DEVELOPMENT

Kinetics of Re-establishing H3K79 Methylation Marks in Global Human Chromatin

(2010) Steve M. M. Sweet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Charting histone modifications and the functional organization of mammalian genomes

(2010) Vicky W. Zhou et al.   NATURE REVIEWS GENETICS

Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T

(2010) H. Tachiwana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global turnover of histone post-translational modifications and variants in human cells

(2010) Barry M Zee et al.   Epigenetics & Chromatin

Mouse TRIP13/PCH2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during Meiosis

(2010) Ignasi Roig et al.   PLoS Genetics

The consequences of asynapsis for mammalian meiosis

(2009) Paul S. Burgoyne et al.   NATURE REVIEWS GENETICS

ES Cell Cycle Progression and Differentiation Require the Action of the Histone Methyltransferase Dot1L

(2009) Evan R. Barry et al.   STEM CELLS

Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase

(2009) Lukasz Wojtasz et al.   PLoS Genetics

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites

(2008) Valérie Borde et al.   EMBO JOURNAL

Drosophila PCH2 Is Required for a Pachytene Checkpoint That Monitors Double-Strand-Break-Independent Events Leading to Meiotic Crossover Formation

(2008) E. F. Joyce et al.   GENETICS

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression

(2008) Jacob L Mueller et al.   NATURE GENETICS

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states

(2008) Floor Frederiks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM Promotes the Obligate XY Crossover and both Crossover Control and Chromosome Axis Integrity on Autosomes

(2008) Marco Barchi et al.   PLoS Genetics

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics

Changes in H3K79 Methylation During Preimplantation Development in Mice

(2007) Masatoshi Ooga et al.   BIOLOGY OF REPRODUCTION