Article
Cell Biology
Xiaoqi Wang, Xiaobin Wu, Pei Zhang, Yuan Zhou, Jun Cai, Ling Jin
Summary: The adaptive immune response mediated by T cells plays a vital role in blood pressure elevation. This study identified four subsets of memory T cells in hypertensive patients and found that CD8 effector memory T cells have more biological functions. Subpopulation 1 of CD8 TEM cells was shown to contribute to blood pressure elevation, and marker genes CKS2, PLIN2, and CNBP were identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Genetics & Heredity
Vivek Chandra, Sourya Bhattacharyya, Benjamin J. Schmiedel, Ariel Madrigal, Cristian Gonzalez-Colin, Stephanie Fotsing, Austin Crinklaw, Gregory Seumois, Pejman Mohammadi, Mitchell Kronenberg, Bjoern Peters, Ferhat Ay, Pandurangan Vijayanand
Summary: This study utilized H3K27ac HiChIP analysis to identify promoter-interacting expression quantitative trait loci (pieQTLs) in five common immune cell types, showing the importance of these variants in gene regulation. Additionally, the study presents a method for functional eQTL discovery and provides insights into the relevance of noncoding variants for cell-specific gene regulation and disease association.
Article
Immunology
Sang Bin Hong, Yong-Won Shin, Ja Bin Hong, Sang Kun Lee, Buhm Han
Summary: This study investigates the commonalities and interrelationships between B cell receptor (BCR) and T cell receptor (TCR) repertoires, finding that they have covarying clonal architecture and diversity. The pattern of correlations appears to change in immune-mediated diseases. The hierarchical clustering of B and T cell clonotypes shows distinct clusters with increased sequence similarity, shared motifs, and distinct amino acid characteristics. These findings suggest shared principles governing memory formation, recombination, and clonal expansion in B and T cells. A significant proportion of the BCR and TCR repertoire can be clustered into nonoverlapping and correlated clusters, providing a novel way of grouping clonotypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Environmental
Jiajun Han, Jesse Fu, Jianxian Sun, David Ross Hall, Diwen Yang, Donovan Blatz, Keith Houck, Carla Ng, Jon Doering, Carlie LaLone, Hui Peng
Summary: The study developed a quantitative interspecies thermal shift assay (QITSA) for investigating chemical-protein interactions across species, using liver fatty acid binding protein (L-FABP) as a case study. Results showed that PFOS exhibited the highest binding affinity to human L-FABP, with variations observed in binding affinities among different species. The experimental strategy implemented in this study may have implications for assessing the toxicity of other chemical contaminants in the future.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Cell Biology
Xi Jia, Tian-Yu Zhai, Bing Wang, Jin-An Zhang, Rong-Hua Song
Summary: The TCR repertoire in patients with autoimmune thyroid diseases (AITDs) is expanded and has many upregulated TRBV genes. The differences in TCR profiles become more pronounced in patients with refractory Graves' disease (RGD) as the disease progresses.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Lu Zhang, Wei Jiao, Hui Deng, Congqi Hu, Jia Xu, Jiahui Yu, Lijuan Liu, Mingying Zhang, Jiduo Liu, Guangxing Chen
Summary: Regulatory T (Treg) cells play an important role in autoimmune diseases such as rheumatoid arthritis (RA). This study investigates the relationship between kidney deficiency (KD), Treg cell subsets, and T-cell receptors (TCRs) in RA patients. The results show that KD is associated with decreased naive Treg cells and altered TCR diversity, indicating impaired Treg cell function.
Article
Medicine, Research & Experimental
Rachel M. Gittelman, Enrico Lavezzo, Thomas M. Snyder, H. Jabran Zahid, Cara L. Carty, Rebecca Elyanow, Sudeb Dalai, Ilan Kirsch, Lance Baldo, Laura Manuto, Elisa Franchin, Claudia Del Vecchio, Monia Pacenti, Caterina Boldrin, Margherita Cattai, Francesca Saluzzo, Andrea Padoan, Mario Plebani, Fabio Simeoni, Jessica Bordini, Nicola Lore, Dejan Lazarevic, Daniela M. Cirillo, Paolo Ghia, Stefano Toppo, Jonathan M. Carlson, Harlan S. Robins, Andrea Crisanti, Giovanni Tonon
Summary: This study investigates the role of T cells in the immune response to SARS-CoV-2 infection, demonstrating their importance in both clinical presentation and long-term immunity. The findings show that T cells contribute to the production of neutralizing antibodies and remain detectable up to 15 months after infection.
Article
Agricultural Engineering
Yihui Liu, Yingmu Wang, Gongduan Fan, Xiaoxuan Su, Jian Zhou, Deming Liu
Summary: In this study, a thiosulfate-driven denitratation system was successfully established with high nitrite accumulation efficiency. Thiosulfate preferred the reduction of nitrate over nitrite, but after depletion, sulfur served as the main electron donor favoring nitrite reduction and constraining nitrite accumulation. Metagenomic sequencing identified key microbe species and metabolic pathways contributing to high NAE in the TDD system.
BIORESOURCE TECHNOLOGY
(2021)
Article
Chemistry, Physical
Hao Ren, Hyung-Sool Lee, Jianwei Zhang, Cameron L. Gardner, Junseok Chae
Summary: This study investigated the EET kinetics of Geobacter sulfurreducens enriched microbial community for a series of biofilm growth stages, revealing the mechanism of EET through quantitative reaction kinetics parameter analysis. Current densities were reported to be less than 2.2 Am-2 and between 2.2 and 3.1 Am-2 in early to mid-stage biofilms.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Immunology
N. H. Servaas, F. Zaaraoui-Boutahar, C. G. K. Wichers, A. Ottria, E. Chouri, A. J. Affandi, S. Silva-Cardoso, M. van der Kroef, T. Carvalheiro, F. van Wijk, T. R. D. J. Radstake, A. C. Andeweg, A. Pandit
Summary: The study shows that CD4(+) and CD8(+) T-cell receptors in Systemic Sclerosis (SSc) patients are highly persistent over time, likely due to antigen selection. Persistent T-cell receptors form clusters with other sequences that potentially recognize the same antigens, supporting antigen-driven expansion of CD4(+)/CD8(+) T-cells in SSc.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Immunology
Jun Zou, Bin Li, Dan Li, Hua-fang Bao, Chun-hui She, Jing-fen Ye, Jian-fei Cai, Jian-long Guan
Summary: T lymphocytes in Behcet's syndrome (BS) pathology exhibit more clonality and less diversity in T-cell receptor (TCR) repertoires. Male patients have lower TCR diversity and higher proportion of top 10 clones. Clonal T-cell expansion and shared antigen recognition between BS patients have been observed, indicating the importance of T-cell-mediated immunity in BS.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Pingsen Zhao, Kaijian Hou, Zhixiong Zhong, Sharula Guo, Songtao Yang, Xianzhu Xia
Summary: Cellular immunity plays a crucial role in host defense against rabies virus infection, but the impact of rabies vaccine on T cell receptor repertoire was unclear. High-throughput sequencing in this study revealed changes in TCR diversity, V/J gene segment usage, and V-J pairing after rabies vaccination. Identification of altered high-frequency clonotypes provides new insights into T cell receptor status post-vaccination.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Yankun Wang, Chu Wang
Summary: This study reveals the dynamic changes of the cysteinome and identifies a sensor switch associated with ferroptosis through a chemical proteomic strategy. It also uncovers a novel functional link between ferroptosis and proteasome-mediated protein degradation.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Qi Chen, Yixian Xiao, Yu Ming, Rong Peng, Jiliang Hu, Hong-Bin Wang, Hong-Lei Jin
Summary: This study investigates the effects of fluctuating light conditions on the redox regulation of photosynthesis in Arabidopsis thaliana. The research shows that photosystem I (PSI) proteins are key targets of redox regulation and that exposure to fluctuating light results in decreased PSI abundance, stability, and activity. Additionally, the study uncovers the role of the PSI assembly factor PSA3 and thioredoxin m (Trx m) proteins in the redox switching of PSI and the overall functioning of photosynthesis. These findings provide insights into how plants acclimate to changing light conditions.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Immunology
Yi Cai, Yejun Wang, Chenyan Shi, Youchao Dai, Fuxiang Li, Yuzhong Xu, Peize Zhang, Fanhui Kong, Guofang Deng, Zhihua Wen, Qi Zhou, Boxi Chris Kang, Amit Singhal, Qianting Yang, Carl G. Feng, Xinchun Chen
Summary: The study reveals the landscape of local T cell immunity in tuberculosis and provides insights into the involvement of specific T cell populations in the pathogenesis of tuberculous pleural effusion (TPE). The findings suggest a link between clonal expansion of Granzyme K-expressing CD8 T cells and TPE.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Connie B. Gilfillan, Chensu Wang, Mona O. Mohsen, Nathalie Rufer, Michael Hebeisen, Mathilde Allard, Gregory Verdeil, Darrell J. Irvine, Martin F. Bachmann, Daniel E. Speiser
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Tiphaine Parrot, Romain Oger, Mathilde Allard, Juliette Desfrancois, Diane Raingeard de la Bletiere, Anne Coutolleau, Laurence Preisser, Amir Khammari, Brigitte Dreno, Yves Delneste, Philippe Guardiola, Delphine Fradin, Nadine Gervois
SCIENTIFIC REPORTS
(2020)
Review
Immunology
Connie B. Gilfillan, Michael Hebeisen, Nathalie Rufer, Daniel E. Speiser
Summary: The functional avidity (FA) of cytotoxic CD8 T cells plays a crucial role in their functional capabilities and protection from infection and cancer. The factors influencing FA and its regulation mechanisms are still not fully understood, but recent research suggests that FA may be stable in vivo due to continued signaling modulation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Aurelia Zimmerli, Matteo Monti, Craig Fenwick, Isabella Eckerle, Catherine Beigelman-Aubry, Celine Pellaton, Katia Jaton, Dominique Dumas, Gian-Marco Stamm, Laura Infanti, Heidrun Andreu-Ullrich, Daphne Germann, Marie Mean, Peter Vollenweider, Raphael Stadelmann, Maura Prella, Denis Comte, Benoit Guery, David Gachoud, Nathalie Rufer
Summary: In this case report, convalescent plasma treatment of an immunosuppressed patient with COVID-19 showed positive effects, including rapid symptom relief, gradual viral clearance, and eventual full recovery. This indicates the potential value of convalescent plasma in treating immunosuppressed COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Stephanie Bibert, Nicolas Guex, Joao Lourenco, Thomas Brahier, Matthaios Papadimitriou-Olivgeris, Lauro Damonti, Oriol Manuel, Robin Liechti, Lou Gotz, Jonathan Tschopp, Mathieu Quinodoz, Peter Vollenweider, Jean-Luc Pagani, Mauro Oddo, Olivier Hugli, Frederic Lamoth, Veronique Erard, Cathy Voide, Mauro Delorenzi, Nathalie Rufer, Fabio Candotti, Carlo Rivolta, Noemie Boillat-Blanco, Pierre-Yves Bochud
Summary: The dysregulated immunity in COVID-19 patients plays a key role in the severity of the disease, including defects in IFN responses, reduced toxicity-related molecules in NK cells, and increased neutrophil degranulation. Additionally, differences in gene expression patterns are also determinants of COVID-19 severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Laetitia Seguin, Soline Odouard, Francesca Corlazzoli, Sarah Al Haddad, Laurine Moindrot, Marta Calvo Tardon, Mayra Yebra, Alexey Koval, Eliana Marinari, Viviane Bes, Alexandre Guerin, Mathilde Allard, Sten Ilmjarv, Vladimir L. Katanaev, Paul R. Walker, Karl-Heinz Krause, Valerie Dutoit, Jann N. Sarkaria, Pierre-Yves Dietrich, Erika Cosset
Summary: The study focused on Gal-3-mediated macropinocytosis in a subset of glioblastoma tumors, showing that inhibition of Gal-3 led to decreased cell survival and invasion. The researchers identified key molecular interactions and defined a signature that predicts sensitivity to this pathway, laying the groundwork for potential therapeutic strategies in a unique subset of GBM patients.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Justine Perrin, Marisa Capitao, Mathilde Allard, Nicolas Chouin, Sebastien Gouard, Severinne Marionneau-Lambot, Cedric Louvet, Emmanuel Donnadieu, Frank Bruchertseifer, Alfred Morgenstern, Michel Cherel, Joelle Gaschet, Yannick Guilloux
Summary: This study investigated the impact of combining targeted alpha particle therapy (TAT) with adoptive cell transfer of CD8 T cells (ACT) on the tumor microenvironment (TME) in a murine model of multiple myeloma (MM). The results showed that TAT treatment improved TME and promoted immune cell infiltration and motility, but subsequently led to the establishment of tumor cell resistance mechanisms.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Lucile Yart, Daniel Bastida-Ruiz, Mathilde Allard, Pierre-Yves Dietrich, Patrick Petignat, Marie Cohen
Summary: This study found that cell fusion may be involved in the formation of ovarian PGCCs, and this process is promoted by paclitaxel and UPR activation. Modulating the UPR could be an interesting therapeutic strategy to prevent the formation of PGCCs and therefore limit cancer relapse and drug resistance.
Article
Immunology
Petra Baumgaertner, Julien Schmidt, Carla-Marisa Costa-Nunes, Natacha Bordry, Philippe Guillaume, Immanuel Luescher, Daniel E. Speiser, Nathalie Rufer, Michael Hebeisen
Summary: This study investigates the impact of peptide:HLA and TCR-pHLA affinities on CD8 T cell responses and cross-reactivity. It is found that vaccines containing native tumor epitopes generate T cells with better functionality and superior cross-reactivity against low affinity escape epitopes. Moreover, different clonotypes of tumor antigen-specific T cells display heterogeneous functional and cross-reactive profiles.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
David Gachoud, Trestan Pillonel, Gerasimos Tsilimidos, Dunia Battolla, Dominique Dumas, Onya Opota, Stefano Fontana, Peter Vollenweider, Oriol Manuel, Gilbert Greub, Claire Bertelli, Nathalie Rufer
Summary: This study found that COVID-19 patients who were pre-exposed to anti-CD20 treatments experienced a more rapid decline in anti-spike IgG levels after plasma therapy, along with longer clinical symptoms and higher viral loads. These patients also had higher mutation rates compared to those who were able to mount an endogenous humoral response, potentially indicating immune escape.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Letter
Hematology
David Gachoud, Claire Bertelli, Nathalie Rufer
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Letter
Hematology
Mathilde Gavillet, Nathalie Rufer, Francesco Grandoni, Mattia Rizzi, Nicolas Vulliemoz, David Baud, Lorenzo Alberio, Giorgia Canellini, Helene Legardeur
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Eliana Marinari, Mathilde Allard, Robin Gustave, Valerie Widmer, Geraldine Philippin, Doron Merkler, Petros Tsantoulis, Valerie Dutoit, Pierre-Yves Dietrich