A Versatile Approach for the Site-Specific Modification of Recombinant Antibodies Using a Combination of Enzyme-Mediated Bioconjugation and Click Chemistry

Enzyme-Mediated Site-Specific Bioconjugation of Metal Complexes to Proteins: Sortase-Mediated Coupling of Copper-64 to a Single-Chain Antibody

(2014) Brett M. Paterson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

(2014) Penelope M. Drake et al.   BIOCONJUGATE CHEMISTRY

MicroPET Imaging of CD13 Expression Using a 64Cu-Labeled Dimeric NGR Peptide Based on Sarcophagine Cage

(2014) Guoquan Li et al.   MOLECULAR PHARMACEUTICS

Single-Chain Antibody Conjugated to a Cage Amine Chelator and Labeled with Positron-Emitting Copper-64 for Diagnostic Imaging of Activated Platelets

(2014) Karen Alt et al.   MOLECULAR PHARMACEUTICS

PET imaging of tumours with a64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate

(2013) Brett M. Paterson et al.   DALTON TRANSACTIONS

The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals

(2013) D. Zeng et al.   JOURNAL OF NUCLEAR MEDICINE

Detection of activated platelets in a mouse model of carotid artery thrombosis with 18F-labeled single-chain antibodies

(2013) Katie Ardipradja et al.   NUCLEAR MEDICINE AND BIOLOGY

Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes

(2013) Lee Kim Swee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thiacycloalkynes for Copper-Free Click Chemistry

(2012) Gabriela de Almeida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells

(2012) Zhipeng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

GPIIb/IIIa inhibitors: From bench to bedside and back to bench again

(2012) Paul C. Armstrong et al.   THROMBOSIS AND HAEMOSTASIS

Making and Breaking Peptide Bonds: Protein Engineering Using Sortase

(2011) Maximilian Wei-Lin Popp et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by sortase A-mediated protein ligation

(2011) Mariusz P. Madej et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro Sortagging of an Antibody Fab Fragment: Overcoming Unproductive Reactions of Sortase with Water and Lysine Side Chains

(2011) Sina Möhlmann et al.   CHEMBIOCHEM

Enzymatic Single-Chain Antibody Tagging

(2011) H.T. Ta et al.   CIRCULATION RESEARCH

Targeting the Platelet Integrin GPIIb/IIIa

(2011) Christoph E. Hagemeyer et al.   CURRENT PHARMACEUTICAL DESIGN

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

(2010) J. R. Junutula et al.   CLINICAL CANCER RESEARCH

Beyond the Canonical 20 Amino Acids: Expanding the Genetic Lexicon

(2010) Travis S. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanomedicine

(2010) Betty Y.S. Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonnatural Amino Acids for Site-Specific Protein Conjugation

(2009) Albert J. de Graaf et al.   BIOCONJUGATE CHEMISTRY

Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

(2009) Kido Nwe et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Platelets: Inflammatory Firebugs of Vascular Walls

(2008) Andreas E. May et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY