Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone
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Title
Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone
Authors
Keywords
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Journal
PLoS One
Volume 7, Issue 7, Pages e39131
Publisher
Public Library of Science (PLoS)
Online
2012-07-03
DOI
10.1371/journal.pone.0039131
References
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Related references
Note: Only part of the references are listed.- Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders
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- Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists
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- Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat
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- Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin
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- Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia
- (2010) Christopher D. Cox et al. JOURNAL OF MEDICINAL CHEMISTRY
- State-dependent central chemoreception: A role of orexin
- (2010) Tomoyuki Kuwaki et al. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
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- Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX2 receptor
- (2009) P Malherbe et al. BRITISH JOURNAL OF PHARMACOLOGY
- Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on anN,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats
- (2009) David B. Whitman et al. ChemMedChem
- Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat
- (2009) C. Dugovic et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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- RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors
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- (2007) Kristian Linnet et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
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