4.7 Article

Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 1, Pages 349-351

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02472d

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Funding

  1. German Science Foundation [HA 4468/2-1]
  2. Max-Buchner Stiftung
  3. Fonds der chemischen Industrie (FCI)
  4. [SFB 765]

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The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield.

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