Recent Advances in Trifluoromethylation Reactions with Electrophilic Trifluoromethylating Reagents

Combining Photoredox-Catalyzed Trifluoromethylation and Oxidation with DMSO: Facile Synthesis of α-Trifluoromethylated Ketones from Aromatic Alkenes

(2014) Ren Tomita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Catalytic Trifluoromethylthiolation of Boronic Acids and Alkynes Employing Electrophilic Shelf-StableN-(trifluoromethylthio)phthalimide

(2014) Roman Pluta et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct C–H trifluoromethylation of di- and trisubstituted alkenes by photoredox catalysis

(2014) Ren Tomita et al.   Beilstein Journal of Organic Chemistry

Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

(2014) Guojing Ji et al.   CHEMICAL COMMUNICATIONS

Pd(0)-Catalyzed radical aryldifluoromethylation of activated alkenes

(2014) Jian-Yong Wang et al.   CHEMICAL COMMUNICATIONS

Fluorinated sulfoximines: syntheses, properties and applications

(2014) Vincent Bizet et al.   CHEMICAL SOCIETY REVIEWS

Addition of CF3 across unsaturated moieties: a powerful functionalization tool

(2014) Estíbaliz Merino et al.   CHEMICAL SOCIETY REVIEWS

Trifluoromethylated Heterocycles

(2014) Andrei Gakh et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

(2014) Gregory Landelle et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent Progress in Asymmetric Fluorination and Trifluoromethylation Reactions

(2014) Vincent Bizet et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

O-Trifluoromethylation ofN,N-Disubstituted Hydroxylamines with Hypervalent Iodine Reagents

(2014) Václav Matoušek et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of α-Trifluoromethyl Ketones via the Cu-Catalyzed Trifluoromethylation of Silyl Enol Ethers Using an Electrophilic Trifluoromethylating Agent

(2014) Lun Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-mediated trifluoromethylation of propargyl acetates leading to trifluoromethyl-allenes

(2014) Yun-Long Ji et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hypervalent iodine: a powerful electrophile for asymmetric α-functionalization of carbonyl compounds

(2014) Dao-Qing Dong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Visible-Light-Promoted Radical C–H Trifluoromethylation of Free Anilines

(2014) Jin Xie et al.   ORGANIC LETTERS

2-Trifluoromethylated Indoles via Radical Trifluoromethylation of Isonitriles

(2014) Bo Zhang et al.   ORGANIC LETTERS

Direct Access to α-Trifluoromethyl Enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer–Schuster Rearrangement

(2014) Ya-Ping Xiong et al.   ORGANIC LETTERS

Highly Regio- and Diastereoselective Synthesis of CF3-Substituted Lactones via Photoredox-Catalyzed Carbolactonization of Alkenoic Acids

(2014) Yusuke Yasu et al.   ORGANIC LETTERS

Catalytic C–H α-Trifluoromethylation of α,β-Unsaturated Carbonyl Compounds

(2014) Zhongxue Fang et al.   ORGANIC LETTERS

Photoredox-Induced Three-Component Oxy-, Amino-, and Carbotrifluoromethylation of Enecarbamates

(2014) Aude Carboni et al.   ORGANIC LETTERS

Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes

(2013) Sébastien Alazet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkene Trifluoromethylation Coupled with CC Bond Formation: Construction of Trifluoromethylated Carbocycles and Heterocycles

(2013) Hiromichi Egami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Trifluoromethylation-Initiated Radical 1,2-Aryl Migration in α,α-Diaryl Allylic Alcohols

(2013) Xiaowu Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Directing-Group-Assisted Copper-Catalyzed Olefinic Trifluoromethylation of Electron-Deficient Alkenes

(2013) Chao Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via aS-(trifluoromethyl)diphenylsulfonium salts/copper system

(2013) Satoshi Okusu et al.   Beilstein Journal of Organic Chemistry

Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent

(2013) Xiao-Ping Wang et al.   Beilstein Journal of Organic Chemistry

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

(2013) Grégory Landelle et al.   Beilstein Journal of Organic Chemistry

Copper-mediated C–H trifluoromethylation of quinones

(2013) Nadia O. Ilchenko et al.   CHEMICAL COMMUNICATIONS

Iron-catalyzed trifluoromethylation with concomitant C–C bond formation via 1,2-migration of an aryl group

(2013) Hiromichi Egami et al.   CHEMICAL COMMUNICATIONS

Visible-light-induced synthesis of a variety of trifluoromethylated alkenes from potassium vinyltrifluoroborates by photoredox catalysis

(2013) Yusuke Yasu et al.   CHEMICAL COMMUNICATIONS

Room temperature decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids by photoredox catalysis

(2013) Pan Xu et al.   CHEMICAL COMMUNICATIONS

Copper-Boxmi Complexes as Highly Enantioselective Catalysts for Electrophilic Trifluoromethylthiolations

(2013) Qing-Hai Deng et al.   CHEMISTRY-A EUROPEAN JOURNAL

In Situ Generation of PhI+CF3and Transition-Metal-Free Oxidative sp2CH Trifluoromethylation

(2013) Cong Xu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metal-mediated radical perfluoroalkylation of organic compounds

(2013) Sebastián Barata-Vallejo et al.   COORDINATION CHEMISTRY REVIEWS

Concise synthesis of oxindole derivatives bearing a 3-trifluoroethyl group: Copper-catalyzed trifluoromethylation of acryloanilides

(2013) Hiromichi Egami et al.   JOURNAL OF FLUORINE CHEMISTRY

Regio- and Diastereoselective Cu-Mediated Trifluoromethylation of Functionalized Alkenes

(2013) Tatiana Besset et al.   JOURNAL OF ORGANIC CHEMISTRY

One-Pot Synthesis of Hypervalent Iodine Reagents for Electrophilic Trifluoromethylation

(2013) Václav Matoušek et al.   JOURNAL OF ORGANIC CHEMISTRY

Use of Fluoroform as a Source of Difluorocarbene in the Synthesis of Difluoromethoxy- and Difluorothiomethoxyarenes

(2013) Charles S. Thomoson et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Hydrotrifluoromethylation of Unactivated Alkenes

(2013) Satoshi Mizuta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes

(2013) Yu-Tao He et al.   ORGANIC LETTERS

Copper-Catalyzed Direct C–H Trifluoromethylation of Quinones

(2013) Xi Wang et al.   ORGANIC LETTERS

Copper- and Iron-Catalyzed Decarboxylative Tri- and Difluoromethylation of α,β-Unsaturated Carboxylic Acids with CF3SO2Na and (CF2HSO2)2Zn via a Radical Process

(2013) Zejiang Li et al.   ORGANIC LETTERS

Isocyanide Insertion: De Novo Synthesis of Trifluoromethylated Phenanthridine Derivatives

(2013) Yuanzheng Cheng et al.   ORGANIC LETTERS

Electrophilic Trifluoromethylthiolation of Allylsilanes with Trifluoromethanesulfanamide

(2013) Jianbo Liu et al.   ORGANIC LETTERS

Pd(II)-Catalyzed Ortho-Trifluoromethylation of Benzylamines

(2013) Masanori Miura et al.   ORGANIC LETTERS

Notification about the Explosive Properties of Togni’s Reagent II and One of Its Precursors

(2013) Nikolaus Fiederling et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development and Challenges in the Copper-Catalyzed Trifluoromethylation of Alkenes

(2013) Xiaoxing Wu et al.   SYNLETT

Recent Advances in Transition-Metal-Catalyzed Trifluoromethylation and Related Transformations

(2013) Guosheng Liu et al.   SYNTHESIS-STUTTGART

Copper-catalyzed trifluoromethylation of arylsulfinate salts using an electrophilic trifluoromethylation reagent

(2013) Xiaoxi Lin et al.   TETRAHEDRON

Recent advance in transition-metal-mediated trifluoromethylation for the construction of C(sp3)–CF3 bonds

(2013) Jun Xu et al.   TETRAHEDRON LETTERS

Copper-Catalyzed Di- and Trifluoromethylation of α,β-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations

(2012) Zhengbiao He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tamed Arene and Heteroarene Trifluoromethylation

(2012) Tatiana Besset et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Electrophilic N-Trifluoromethylation of Azoles by a Hypervalent Iodine Reagent

(2012) Katrin Niedermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Three-component Oxytrifluoromethylation of Alkenes: Highly Efficient and Regioselective Difunctionalization of CC Bonds Mediated by Photoredox Catalysts

(2012) Yusuke Yasu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron(II)-Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates

(2012) Andrew T. Parsons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals

(2012) Yang Li et al.   CHEMICAL COMMUNICATIONS

Recent Developments on the Trifluoromethylation of (Hetero)Arenes

(2012) Xiao-Feng Wu et al.   Chemistry-An Asian Journal

The New Age of Electrophilic Perfluoro­alk­ylation Reactions

(2012) Yohan Macé et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Oxytrifluoromethylation of Unactivated Alkenes

(2012) Rong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective Copper-Catalyzed Electrophilic Trifluoromethylation of β-Ketoesters

(2012) Qing-Hai Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrophilic Trifluoromethylation by Copper-Catalyzed Addition of CF3-Transfer Reagents to Alkenes and Alkynes

(2012) Pär G. Janson et al.   ORGANIC LETTERS

Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

(2012) Yuanyuan Huang et al.   TETRAHEDRON

Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

(2012) Zhiqiang Weng et al.   TETRAHEDRON

Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

(2012) Huidong Zheng et al.   TETRAHEDRON LETTERS

Rhenium-Catalyzed Trifluoromethylation of Arenes and Heteroarenes by Hypervalent Iodine Reagents

(2012) Esteban Mejía et al.   ACS Catalysis

Cation versus Radical: Studies on the C/O Regioselectivity in Electrophilic Tri-, Di- and Monofluoromethylations of β-Ketoesters

(2012) Yu-Dong Yang et al.   ChemistryOpen

Efficient Trifluoromethylation of Activated and Non-Activated Alkenyl Halides by Using (Trifluoromethyl)trimethylsilane

(2011) Andreas Hafner et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-catalyzed trifluoromethylation of aryl boronic acids using a CF3+ reagent

(2011) Jun Xu et al.   CHEMICAL COMMUNICATIONS

Enantioselective Organocatalytic Synthesis of Fluorinated Molecules

(2011) Guillem Valero et al.   CHEMISTRY-A EUROPEAN JOURNAL

N,N-Dimethyl-S-difluoromethyl-S-phenylsulfoximinium tetrafluoroborate: A versatile electrophilic difluoromethylating reagent

(2011) G.K. Surya Prakash et al.   JOURNAL OF FLUORINE CHEMISTRY

Reactivity of an electrophilic hypervalent iodine trifluoromethylation reagent with hydrogen phosphates—A mechanistic study

(2011) Nico Santschi et al.   JOURNAL OF FLUORINE CHEMISTRY

Ionic liquids as new media for electrophilic trifluoromethylation reactions

(2011) Bruce Pégot et al.   JOURNAL OF FLUORINE CHEMISTRY

Electrophilic Trifluoromethylation ofS-Hydrogen Phosphorothioates

(2011) Nico Santschi et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Oxidative Aryltrifluoromethylation of Activated Alkenes at Room Temperature

(2011) Xin Mu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed C(sp3)–C(sp3) Bond Formation Using a Hypervalent Iodine Reagent: An Efficient Allylic Trifluoromethylation

(2011) Xi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Synthesis of α-CF3-Substituted Carbonyl Compounds with Relative and Absolute Stereocontrol Using Electrophilic CF3-Transfer Reagents

(2011) Václav Matoušek et al.   ORGANIC LETTERS

Cu-Mediated Chemoselective Trifluoromethylation of Benzyl Bromides Using Shelf-Stable Electrophilic Trifluoromethylating Reagents

(2011) Hiroyuki Kawai et al.   ORGANIC LETTERS

Copper-Catalyzed Trifluoromethylation of Aryl and Vinyl Boronic Acids with An Electrophilic Trifluoromethylating Reagent

(2011) Tianfei Liu et al.   ORGANIC LETTERS

The Palladium-Catalyzed Trifluoromethylation of Vinyl Sulfonates

(2011) Eun Jin Cho et al.   ORGANIC LETTERS

Asymmetric Electrophilic Fluorination Using an Anionic Chiral Phase-Transfer Catalyst

(2011) V. Rauniyar et al.   SCIENCE

Combination Catalysis in Enantioselective Trifluoromethylation

(2010) Yan Zheng et al.   ADVANCED SYNTHESIS & CATALYSIS

A Ritter-Type Reaction: Direct Electrophilic Trifluoromethylation at Nitrogen Atoms Using Hypervalent Iodine Reagents

(2010) Katrin Niedermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

(2010) Norio Shibata et al.   Beilstein Journal of Organic Chemistry

Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

(2010) Jing Nie et al.   CHEMICAL REVIEWS

Electrophilic trifluoromethylation of arenes and N-heteroarenes using hypervalent iodine reagents

(2010) Matthias S. Wiehn et al.   JOURNAL OF FLUORINE CHEMISTRY

Pd(II)-Catalyzedortho-Trifluoromethylation of Arenes Using TFA as a Promoter

(2010) Xisheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cinchona Alkaloid-Catalyzed Asymmetric Trifluoromethylation of Alkynyl Ketones with Trimethylsilyl Trifluoromethane

(2010) Hiroyuki Kawai et al.   ORGANIC LETTERS

Electrophilic Trifluoromethylation of Primary Phosphines: Synthesis of aP-Bis(trifluoromethyl) Derivative of BINAP

(2010) Nicolas Armanino et al.   ORGANOMETALLICS

Trifluoromethyl-substituted cyclopropanes

(2010) Oleksandr O. Grygorenko et al.   TETRAHEDRON

Mechanistical insight into ‘electrophilic’ trifluoromethylation with S-(trifluoromethyl)dibenzothiophenium salts

(2010) Yohan Macé et al.   TETRAHEDRON LETTERS

Enantioselective electrophilic trifluoromethylation of β-keto esters with Umemoto reagents induced by chiral nonracemic guanidines

(2009) Shun Noritake et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic Allylic C−H Acetoxylation and Benzoyloxylation via Suggested (η3-Allyl)palladium(IV) Intermediates

(2009) Lukasz T. Pilarski et al.   ORGANIC LETTERS

Recent advances in enantioselective trifluoromethylation reactions

(2009) Norio Shibata et al.   TETRAHEDRON-ASYMMETRY

Mild electrophilic trifluoromethylation of secondary and primary aryl- and alkylphosphines using hypervalent iodine(iii)–CF3 reagents

(2008) Patrick Eisenberger et al.   CHEMICAL COMMUNICATIONS

Fluorinated Johnson Reagent for Transfer-Trifluoromethylation to Carbon Nucleophiles

(2008) Shun Noritake et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Reactivity of a 10-I-3 Hypervalent Iodine Trifluoromethylation Reagent With Phenols

(2008) Kyrill Stanek et al.   JOURNAL OF ORGANIC CHEMISTRY