Wnt Signaling Cascades and the Roles of Syndecan Proteoglycans

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases

(2014) Hooi Ching Lim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cell-cell interaction in the heart via Wnt/ -catenin pathway after cardiac injury

(2014) A. Deb   CARDIOVASCULAR RESEARCH

Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans

(2014) K. Dejima et al.   DEVELOPMENT

Insight into planar cell polarity

(2014) Michael Sebbagh et al.   EXPERIMENTAL CELL RESEARCH

Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer

(2014) Achilleas D. Theocharis et al.   FEBS Journal

Fell-Muir Lecture: Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour

(2014) John R. Couchman et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Shed Syndecan-1 Translocates to the Nucleus of Cells Delivering Growth Factors and Inhibiting Histone Acetylation

(2014) Mark D. Stewart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling

(2014) M. Capurro et al.   JOURNAL OF CELL SCIENCE

Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling

(2014) Sherif A. Ibrahim et al.   PLoS One

Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population

(2014) Rachel K. Okolicsanyi et al.   TUMOR BIOLOGY

Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy

(2013) Yimin Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt signaling in liver fibrosis: Progress, challenges and potential directions

(2013) Cheng-gui Miao et al.   BIOCHIMIE

The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

(2013) M. Kaucka et al.   CANCER RESEARCH

Fibronectin Regulates Wnt7a Signaling and Satellite Cell Expansion

(2013) C. Florian Bentzinger et al.   Cell Stem Cell

Secretion and extracellular space travel of Wnt proteins

(2013) Julia Christina Gross et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity

(2013) N. Escobedo et al.   DEVELOPMENT

The Meckel syndrome protein meckelin (TMEM67) is a key regulator of cilia function but is not required for tissue planar polarity

(2013) Amanda C. Leightner et al.   HUMAN MOLECULAR GENETICS

Syndecan-4 inhibits Wnt/β-catenin signaling through regulation of low-density-lipoprotein receptor-related protein (LRP6) and R-spondin 3

(2013) Pablo Astudillo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

(2013) Rochelle M. Witt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DrosophilaHeparan Sulfate 6-O-Endosulfatase Sulf1 Facilitates Wingless (Wg) Protein Degradation

(2013) Adam Kleinschmit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mediators for Raft-dependent Endocytosis of Syndecan-1, a Highly Conserved, Multifunctional Receptor

(2013) Keyang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs

(2013) Floriane Pez et al.   JOURNAL OF HEPATOLOGY

Syndecan-1, a Cell Surface Proteoglycan, Negatively Regulates Initial Leukocyte Recruitment to the Brain across the Choroid Plexus in Murine Experimental Autoimmune Encephalomyelitis

(2013) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development

(2013) Amy R Barker et al.   Organogenesis

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Alpha-actinin interactions with syndecan-4 are integral to fibroblast–matrix adhesion and regulate cytoskeletal architecture

(2012) E. Okina et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Frizzled homolog proteins, microRNAs and Wnt signaling in cancer

(2012) Koji Ueno et al.   INTERNATIONAL JOURNAL OF CANCER

VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration

(2012) B. B. Williams et al.   JOURNAL OF CELL SCIENCE

An Introduction to Proteoglycans and Their Localization

(2012) John R. Couchman et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress

(2012) Kate M. Herum et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Tangled Web of Non-Canonical Wnt Signalling in Neural Migration

(2012) Charlotte E.J. Clark et al.   NEUROSIGNALS

Comparison of Phenotypes between Different vangl2 Mutants Demonstrates Dominant Effects of the Looptail Mutation during Hair Cell Development

(2012) Haifeng Yin et al.   PLoS One

The Niche Factor Syndecan-1 Regulates the Maintenance and Proliferation of Neural Progenitor Cells during Mammalian Cortical Development

(2012) Qingjie Wang et al.   PLoS One

Targeting Wnt Pathways in Disease

(2012) Z. F. Zimmerman et al.   Cold Spring Harbor Perspectives in Biology

Alternative Wnt Pathways and Receptors

(2012) R. van Amerongen   Cold Spring Harbor Perspectives in Biology

Syndecan-4 signalling inhibits apoptosis and controls NFAT activity during myocardial damage and remodelling

(2011) Frank Echtermeyer et al.   CARDIOVASCULAR RESEARCH

Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis

(2011) Bisei Ohkawara et al.   DEVELOPMENTAL CELL

Mutations in the planar cell polarity genesCELSR1andSCRIBare associated with the severe neural tube defect craniorachischisis

(2011) Alexis Robinson et al.   HUMAN MUTATION

Syndecan-1 and Syndecan-4 Are Independent Indicators in Breast Carcinoma

(2011) Maria E. Lendorf et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Frizzled3 Is Required for Neurogenesis and Target Innervation during Sympathetic Nervous System Development

(2011) A. Armstrong et al.   JOURNAL OF NEUROSCIENCE

Molecular functions of syndecan-1 in disease

(2011) Yvonne Hui-Fang Teng et al.   MATRIX BIOLOGY

FZD7 has a critical role in cell proliferation in triple negative breast cancer

(2011) L Yang et al.   ONCOGENE

Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway

(2011) Alexandra V. Finsen et al.   PLoS One

Transmembrane Signaling Proteoglycans

(2010) John R. Couchman   Annual Review of Cell and Developmental Biology

The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome

(2010) T. Prebet et al.   BLOOD

WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma

(2010) Jisheng Li et al.   CANCER BIOLOGY & THERAPY

Proteoglycans in health and disease: the multiple roles of syndecan shedding

(2010) Tina Manon-Jensen et al.   FEBS Journal

Serine 34 Phosphorylation of Rho Guanine Dissociation Inhibitor (RhoGDIα) Links Signaling from Conventional Protein Kinase C to RhoGTPase in Cell Adhesion

(2010) Athanassios Dovas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-canonical Wnt Signaling Induces Ubiquitination and Degradation of Syndecan4

(2010) Loreto Carvallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecans as cell surface receptors: Unique structure equates with functional diversity

(2010) Youngsil Choi et al.   MATRIX BIOLOGY

When pathways collide: collaboration and connivance among signalling proteins in development

(2010) Helen McNeill et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

VANGL2Mutations in Human Cranial Neural-Tube Defects

(2010) Yun-Ping Lei et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Role for Wnt/Ca2+ Signaling in Actin Cytoskeleton Remodeling and Cell Motility in Prostate Cancer

(2010) Qin Wang et al.   PLoS One

Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis

(2010) S. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Syndecans as receptors and organizers of the extracellular matrix

(2009) Xiaojie Xian et al.   CELL AND TISSUE RESEARCH

SDN-1/syndecan regulates growth factor signaling in distal tip cell migrations in C. elegans

(2009) Megan Schwabiuk et al.   DEVELOPMENTAL BIOLOGY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

(2009) Akira Sato et al.   EMBO JOURNAL

Sdc1 negatively modulates carcinoma cell motility and invasion

(2009) Tohru Ishikawa et al.   EXPERIMENTAL CELL RESEARCH

Heparan Sulfate Proteoglycan Modulation of Wnt5A Signal Transduction in Metastatic Melanoma Cells

(2009) Michael P. O'Connell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 regulates αvβ3and αvβ5integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

(2009) DeannaLee M. Beauvais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure

(2009) Janna Merte et al.   NATURE CELL BIOLOGY

A wound-induced Wnt expression program controls planarian regeneration polarity

(2009) C. P. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syndecan proteoglycan contributions to cytoskeletal organization and contractility

(2009) E. Okina et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Planar Cell Polarity Signaling: From Fly Development to Human Disease

(2008) Matias Simons et al.   Annual Review of Genetics

Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA

(2008) H. K. Matthews et al.   DEVELOPMENT

WGEF activates Rho in the Wnt–PCP pathway and controls convergent extension in Xenopus gastrulation

(2008) Kosuke Tanegashima et al.   EMBO JOURNAL

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of  -catenin in mice

(2008) T. Grigoryan et al.   GENES & DEVELOPMENT

Structural and Cell Adhesion Properties of Zebrafish Syndecan-4 Are Shared with Higher Vertebrates

(2008) James R. Whiteford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p190RhoGAP is the convergence point of adhesion signals from α5β1integrin and syndecan-4

(2008) Mark D. Bass et al.   JOURNAL OF CELL BIOLOGY

The ins and outs of syntenin, a multifunctional intracellular adaptor protein

(2008) J. M. Beekman et al.   JOURNAL OF CELL SCIENCE

Integration of Protein Kinases mTOR and Extracellular Signal-Regulated Kinase 5 in Regulating Nucleocytoplasmic Localization of NFATc4

(2008) T. T. C. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Postsynaptic Density 95/Disc-Large/Zona Occludens Protein Syntenin Directly Interacts with Frizzled 7 and Supports Noncanonical Wnt Signaling

(2008) Annouck Luyten et al.   MOLECULAR BIOLOGY OF THE CELL

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

(2008) Melanie Königshoff et al.   PLoS One