4.7 Article

Photocontrolled chignolin-derived β-hairpin peptidomimetics

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 19, Pages 4001-4004

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc10304a

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Funding

  1. LMU Munich
  2. Deutsche Forschungsgemeinschaft [SFB 749]
  3. Excellence Cluster CIPSM - Center of Integrated Protein Science Munich

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The synthesis of novel, chignolin-derived peptides comprising the azobenzene photoswitch [3-(3-aminomethyl)phenylazo]phenylacetic acid (AMPP) is reported. Reversible photoswitching behavior led to folding into beta-hairpin-like structures, as unequivocally demonstrated by CD, FT-IR and NMR spectroscopy.

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