Review
Cell Biology
Miguel A. Bermudez, Laura Pereira, Cristina Fraile, Laura Valerio, Maria A. Balboa, Jesus Balsinde
Summary: In this review, the effects of monounsaturated hexadecenoic fatty acids, particularly palmitoleic acid, on metabolic diseases are discussed. Palmitoleic acid has been described as a lipokine that regulates various metabolic processes. The biological effects of sapienic acid and hypogeic acid are still poorly understood, but accumulating evidence suggests their importance in metabolic regulation.
Article
Neurosciences
Ao Qi, Lulu Liu, Junjie Zhang, Simei Chen, Simin Xu, Yusen Chen, Lijiang Zhang, Chun Cai
Summary: Parkinson's disease (PD) is a progressive neurodegenerative disorder with no clear clinical biomarkers. In this study, plasma metabolites were analyzed and short-chain fatty acids showed differences between PD patients and healthy controls. Acetic acid was higher in PD, while propanoic acid and 2,3,4-trihydroxybutyric acid were lower. Acetic acid and propanoic acid were found to be potential biomarkers for differentiating PD from health, with propanoic acid showing the highest sensitivity and specificity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Neda Ghamarzad Shishavan, Ashraf Mohamadkhani, Sadaf Ghajarieh Sepanlou, Sahar Masoudi, Maryam Sharafkhah, Hossein Poustchi, Azita Hekmatdoost, Akram Pourshams
Summary: The study found that high levels of ω-3 and monounsaturated fatty acids were negatively associated with the risk of pancreatic cancer, while high levels of ω-6 fatty acids were positively associated. These results suggest that different types of fatty acids are closely related to the risk of pancreatic cancer.
CLINICAL NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
M. Henno, K. Ling, T. Kaart, T. Ariko, P. Karis, H. Jaakson, S. Kuusik, M. Ots
Summary: This study examined the effects of precalving administration of a continuous-release monensin capsule on post-calving milk fatty acid profile and the accuracy of fatty acids as a biomarker for early identification of cows with elevated blood plasma nonesterified fatty acids. The results showed that specific threshold values for the identification of cows with elevated NEFA and HYK could only be applicable within similar feeding conditions and rumen environment, highlighting the importance of considering individual cow factors in interpreting biomarker results.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Huang Huang, Guozhu Ye, Song-qing Lai, Hua-xi Zou, Bin Yuan, Qi-cai Wu, Li Wan, Qun Wang, Xue-liang Zhou, Wen-jun Wang, Yuan-ping Cao, Jian-feng Huang, Shi-li Chen, Bi-cheng Yang, Ji-chun Liu
Summary: This study utilized an untargeted lipidomic approach to identify plasma lipidomic alterations and potential biomarkers in patients with AD. The findings suggest that many lipid species are significantly altered in AD patients, with lysophosphatidylcholines showing promise as excellent potential biomarkers for identifying AD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Plant Sciences
Yin-Ping Zhang, Yuan-Yuan Zhang, Kiran Thakur, Fan Zhang, Fei Hu, Jian-Guo Zhang, Peng-Cheng Wei, Zhao-Jun Wei
Summary: The study reveals 32 pairs of miRNA targets with negatively correlated expression profiles, of which 12 miRNA-target pairs were confirmed through RT-PCR. In addition, a regulatory co-expression network was constructed based on the differentially expressed gene profiles. The FAD2, LOC10515945, LOC105161564, and LOC105162196 genes were clustered into groups regulating the accumulation of unsaturated fatty acid biosynthesis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Analytical
Mengxia Cheng, Hong Shu, Ye Peng, Xiaoxiao Feng, Guoquan Yan, Lei Zhang, Jun Yao, Huimin Bao, Haojie Lu
Summary: A comprehensive strategy combining linkage-specific derivatization and charge-sensitive separation method was developed for specific analysis of alpha-2,3-sialylated N-glycan linkage isomers. This new approach demonstrated successful sensitive profiling and reproducible quantitation of serum alpha-2,3-sialylated N-glycome from ovarian cancer patients, identifying significant changes in certain glycan structures.
ANALYTICAL CHEMISTRY
(2021)
Article
Critical Care Medicine
James D. Guest, Margot Kelly-Hedrick, Theresa Williamson, Christine Park, Daniyal Mansoor Ali, Ahilan Sivaganesan, Chris J. Neal, Charles H. Tator, Michael G. Fehlings
Summary: Traumatic spinal cord injury (SCI) is a sudden onset multi-system disease that permanently disrupts homeostasis and leads to multiple complications. The molecular pathobiology of the factors that modify the recovery-chronic syndrome trajectory in SCI patients is largely unknown, with significant gaps in data between early treatment and chronic phases. Changes in organ function and interactions between interdependent systems disrupt homeostasis and generate progression-driving allostatic load. Current classifications of SCI and acute injury outcome predictors often do not accurately predict chronic SCI syndrome phenotypes. To address these limitations, a topological phenotype framework integrating bioinformatics, physiological data, and allostatic load can potentially reveal crucial intervention points to improve recovery trajectories.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Chemistry, Analytical
Jiangshuo Li, Jing Xu, Ruiping Zhang, Jiuming He, Manjiangcuo Wang, Guanggen Jiao, Zeper Abliz
Summary: In this study, a targeted strategy for screening fatty acids was developed using parallel labeling and high-resolution mass spectrometry analysis. The method was successfully applied to determine fatty acid levels in plasma samples from esophageal squamous cell carcinoma patients and healthy controls, revealing six altered fatty acids affected by tumor invasion. This method provides insights into the identification of unknown fatty acids and has potential applications in clinical diagnosis and the study of disease mechanisms.
Article
Biochemistry & Molecular Biology
Gwang-Woo Kim, Jae-Man Sim, Yutaka Itabashi, Min-Jeong Jung, Joon-Young Jun
Summary: Research on the characteristic fatty acid composition of the red alga Solieria pacifica revealed the presence of unusual cyclic fatty acids, including two cyclopentyl fatty acids and a cyclopropane fatty acid which were not previously found in other algae. The cyclopropane fatty acid, in particular, is primarily found in bacteria, rumen microorganisms or foods of animal origin.
Article
Cardiac & Cardiovascular Systems
Neil K. Huang, Mary L. Biggs, Nirupa R. Matthan, Luc Djousse, W. T. Longstreth, Kenneth J. Mukamal, David S. Siscovick, Alice H. Lichtenstein
Summary: The study found associations between NEFA subclasses and individual NEFAs with incident stroke, particularly highlighting the potential of n-3 subclass and dihomo-y-linolenic acid as biomarkers for total stroke risk. Exclusions of cases with hemorrhagic stroke resulted in non-significant associations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Gastroenterology & Hepatology
Eunyoung Lee, Hannelie Korf, Antonio Vidal-Puig
Summary: The liver and white adipose tissue play critical roles in regulating systemic energy balance. While they can adapt to energy surplus to a certain extent, excessive accumulation of fat in adipose tissue can lead to metabolic disturbances and inflammation. This can result in liver overload and the development of diseases such as non-alcoholic fatty liver.
JOURNAL OF HEPATOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
My Tuyen T. Nguyen, Jieun Kim, Nari Seo, A. Hyun Lee, Yong-Ki Kim, Ji A. Jung, Dan Li, Xuan Hong M. To, Khanh Trang N. Huynh, Thanh Van Le, Beenish Israr, Anum Nazir, Jung-A Seo, Daum Lee, Hyun Joo An, Jaehan Kim
Summary: The study found significant differences in human milk fatty acid compositions among different Asian countries, with Pakistani breast milk having high saturated fat content and low unsaturated fatty acids, indicating the need for DHA supplementation in infants. Additionally, the average DHA: ARA ratio in Asian human milk was 1.01.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Genetics & Heredity
Yikai Luo, Han Liang
Summary: The study analyzed the amino acid usage preference in different cancer types and found a convergent pattern towards using biosynthetically low-cost amino acids. A single index based on the average biosynthetic energy cost of amino acids accurately captured this trend.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Chemistry, Applied
Ana Luiza Fontes, Bruna Neves, Tiago Conde, Daniela Couto, Ligia Leao Pimentel, Luis Miguel Rodriguez-Alcala, M. Rosario Domingues, Ana Maria Gomes
Summary: This study investigated potential fatty acid byproducts during microbial enrichment of CLA/CLNA and found that no additional side-fatty acid metabolites were released except for stearic acid in the presence of linoleic acid.
Article
Energy & Fuels
Thomas Paul Weiss, Ignacio Minguez-Bacho, Elena Zuccala, Michele Melchiorre, Nathalie Valle, Brahime El Adib, Tadahiro Yokosawa, Erdmann Spiecker, Julien Bachmann, Phillip J. Dale, Susanne Siebentritt
Summary: This study focuses on the open-circuit voltage improvement of Sb2Se3 thin film solar cells. It is found that post-deposition annealing can effectively reduce interface recombination, increase activation energy, and improve photoluminescence yield. Additionally, atomic layer-deposited intermediate buffer layers such as TiO2 or Sb2S3 can overcome the limitation of short-circuit current density.
PROGRESS IN PHOTOVOLTAICS
(2023)
Article
Biochemistry & Molecular Biology
Elisabetta Del Duca, Anna Sansone, Mayla Sgrulletti, Federica Di Nolfo, Loredana Chini, Carla Ferreri, Viviana Moschese
Summary: Peanut allergy is a lifelong and potentially life-threatening disease that affects families and communities. A preliminary study explored the fatty-acid-based membrane lipidome profile of patients with angioedema and/or anaphylaxis after peanut ingestion. The study found significant differences in the levels of omega-6 and omega-3 fatty acids between allergic patients and healthy individuals, as well as a correlation between specific immunoglobulin E (IgE) levels and certain fatty acids. The results of this study suggest the need for larger screenings and further research to understand the molecular mechanisms and develop effective treatments for chronic allergic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Izabela Burzynska-Pedziwiatr, Danuta Dudzik, Anna Sansone, Beata Malachowska, Andrzej Zieleniak, Monika Zurawska-Klis, Carla Ferreri, Chryssostomos Chatgilialoglu, Katarzyna Cypryk, Lucyna A. Wozniak, Michal J. Markuszewski, Malgorzata Bukowiecka-Matusiak
Summary: Gestational diabetes mellitus (GDM) is a disorder related to glucose metabolism during pregnancy. Our study found higher levels of 2-hydroxybutyric and 3-hydroxybutyric acids in the plasma of GDM patients, which are associated with impaired glucose metabolism. We also observed significant changes in the fatty acid composition of cholesteryl esters in GDM patients' plasma. Our findings highlight the importance of hydroxybutyric acid derivatives, cholesteryl ester composition, and the reduction of oleic acid in the pathophysiology of GDM.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Cell Biology
Elisabetta Chiaradia, Anna Sansone, Carla Ferreri, Brunella Tancini, Raffaella Latella, Alessia Tognoloni, Angela Gambelunghe, Marco Dell'Omo, Lorena Urbanelli, Stefano Giovagnoli, Roberto Maria Pellegrino, Giada Cerrotti, Carla Emiliani, Sandra Buratta
Summary: Cigarette smoke exposure can cause tissue damage through oxidative stress. In this study, the content and characteristics of extracellular vesicles (EVs) released by bronchial epithelial cells exposed to cigarette smoke extract (CSE) were evaluated. The findings provide insights into the biological effects of CSE-related EVs and their potential as diagnostic markers for smoke-induced lung damage and diseases.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Agnese Stanzani, Anna Sansone, Cinzia Brenna, Vito Antonio Baldassarro, Giuseppe Alastra, Luca Lorenzini, Chryssostomos Chatgilialoglu, Ilaria Laface, Carla Ferreri, Luca Maria Neri, Laura Calza
Summary: The study analyzed changes in lipid composition due to inflammatory conditions. The fatty acid composition was measured in erythrocytes and spinal cord tissue of mice affected by experimental allergic encephalomyelitis (EAE). The results showed a decrease in PUFAs and an increase in SFAs in the membrane during the acute phase of EAE, while PUFAs decreased in the spinal cord tissue.
Article
Biochemistry & Molecular Biology
Carla Ferreri, Alessandra Ferocino, Gessica Batani, Chryssostomos Chatgilialoglu, Vanda Randi, Maria Vittoria Riontino, Fabrizio Vetica, Anna Sansone
Summary: Plasmalogens are membrane phospholipids that play a role in peroxidation and have the potential for cis-trans double bond isomerization. Through experiments using representative molecules and liposomes under specific conditions, the reactivity and outcomes of these processes were studied. The results provide important insights for lipidomic applications and understanding radical stress in living organisms.
Article
Biochemistry & Molecular Biology
Yusuke Hirata, Carla Ferreri, Yuto Yamada, Aya Inoue, Anna Sansone, Fabrizio Vetica, Wakana Suzuki, Saya Takano, Takuya Noguchi, Atsushi Matsuzawa, Chryssostomos Chatgilialoglu
Summary: Geometrical mono-trans isomers of arachidonic acid play a role in programmed cell death, particularly ferroptosis. Analysis of membrane fatty acid composition reveals the relationship between mono-trans isomers and cell fate in ferroptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Nutrition & Dietetics
Anna Olejnik, Justyna Gornowicz-Porowska, Dorota Jenerowicz, Adriana Polanska, Malgorzata Dobrzynska, Juliusz Przyslawski, Anna Sansone, Carla Ferreri
Summary: The prevalence of atopic dermatitis, especially in urban populations, has increased drastically. This multifactorial skin disease is caused by complex interactions between genetics, environment, lifestyle, and diet. In eczema, fatty acids from foods play an important role in immunomodulation and lipid metabolism, affecting the epidermal barrier functioning and the formation of bioactive lipids. Understanding the composition of membrane fatty acids and their supplementation can lead to personalized strategies for achieving an anti-inflammatory outcome in skin disorders.
Article
Biochemistry & Molecular Biology
Annalisa Masi, Amedeo Capobianco, Krzysztof Bobrowski, Andrea Peluso, Chryssostomos Chatgilialoglu
Summary: This study investigates the reaction of hydroxyl radicals and sulfate radical anions with a double-stranded oligodeoxynucleotide under anoxic conditions. The results suggest that the alternating GC sequences in the DNA structure allow for a new type of electron hole stabilization.
