Article
Biochemistry & Molecular Biology
Zhenghua Wang, Cancan Zhao, Chuanlin Wang, Hang Zhang, Dejun Ma, Qiangzhe Zhang, Xin Wen, Luyuan Li, Zhen Xi
Summary: Inosine-containing CDNs have the potential to activate all five major hSTING variants, showing promise as novel immune therapy activators. Molecular dynamic simulations and ITC assays further confirm the interaction mechanisms, providing insights for future drug development.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Mengdi Shang, Kuan Lu, Wenli Guan, Shujie Cao, Mengtian Ren, Chuanzheng Zhou
Summary: The cGAS-STING pathway is a vital part of the innate immune system, with 2',3'-cGAMP serving as a key second messenger. Research on 2',3'-cGAMP analogues for immunotherapeutic potential has been increasingly popular over the past decade.
Article
Engineering, Biomedical
Meike N. Leiske, May Lai, Thakshila Amarasena, Thomas P. Davis, Kristofer J. Thurecht, Stephen J. Kent, Kristian Kempe
Summary: The study demonstrates that PMeOx polymer structures show weaker interactions with immune cells in human blood, indicating their potential advantages in biomedical applications.
Review
Medicine, General & Internal
Claire S. S. Whyte
Summary: The hemostatic and innate immune system have intricate interactions. Inflammation in blood vessels promotes thrombus formation, while fibrin is involved in the innate immune response against invading pathogens. This interplay led to the introduction of the terms thromboinflammation and immunothrombosis. Once a thrombus forms, the fibrinolytic system is responsible for resolving and removing clots. Immune cells possess fibrinolytic regulators and plasmin, the central fibrinolytic enzyme, which also have diverse roles in immune regulation. This article discusses the intricate relationship between the fibrinolytic and innate immune system.
FRONTIERS IN MEDICINE
(2023)
Article
Veterinary Sciences
Qi Wu, Zhixian Lin, Jinsen Wu, Kun Qian, Hongxia Shao, Jianqiang Ye, Aijian Qin
Summary: The study developed a peptide enzyme-linked immunosorbent assay (pELISA) as a possible alternative to the neutralization test for evaluating the immune response to IBV vaccine. The pELISA could indirectly evaluate neutralizing antibody titers against different types of IBV in all tested sera, with a coefficient of 0.83 for neutralizing antibody titers. The pELISA has the potential to detect antibodies against different types of IBV in all tested sera and surveillance the infection of IBV.
BMC VETERINARY RESEARCH
(2021)
Article
Immunology
Johann Lechner, Marlene Schmidt, Volker von Baehr, Fabian Schick
Summary: This study identified the presence of BMDJ and overexpression of R/C in seven different systemic immunological diseases. The findings highlight the significant roles played by BMDJ and R/C in inflammatory and immune diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Neurosciences
Hwayoung Lee, Sung Wook Kang, Hyeonjung Jeong, Jun-Tack Kwon, Young Ock Kim, Hak-Jae Kim
Summary: The study found that the expression of Cngb1 decreased in a mouse model of schizophrenia, and a SNP in the human CNGB1 gene was associated with the risk of schizophrenia. This suggests that CNGB1 may be involved in the pathophysiology of schizophrenia.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Changhao Wang, Brandon Carter-Cooper, Yixuan Du, Jie Zhou, Musabbir A. Saeed, Jinbing Liu, Min Guo, Benjamin Roembke, Clinton Mikek, Edwin A. Lewis, Rena G. Lapidus, Herman O. Sintim
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Xiaochu Ma, Jie Zhou, Changhao Wang, Brandon Carter-Cooper, Fan Yang, Elizabeth Larocque, Jonathan Fine, Genichiro Tsuji, Gaurav Chopra, Rena G. Lapidus, Herman O. Sintim
ACS MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Multidisciplinary Sciences
Sebastian Knorr, Malte Sinn, Dmitry Galetskiy, Rhys M. Williams, Changhao Wang, Nicolai Mueller, Olga Mayans, David Schleheck, Joerg S. Hartig
NATURE COMMUNICATIONS
(2018)
Article
Nanoscience & Nanotechnology
Dongmei Zhang, Guanke Cai, Somnath Mukherjee, Yajuan Sun, Changhao Wang, Bingjie Mai, Kaiqiang Liu, Cheng Yang, Yashao Chen
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Changhao Wang, Min Hao, Qianqian Qi, Jingshuang Dang, Xingchen Dong, Shuting Lv, Ling Xiong, Huanhuan Gao, Guoqing Jia, Yashao Chen, Joerg S. Hartig, Can Li
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Organic
Qianqian Qi, Shuting Lv, Min Hao, Xingchen Dong, Youkun Gu, Peizhe Wu, Wenyue Zhang, Yashao Chen, Changhao Wang
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Materials Science, Biomaterials
Wancheng Zhu, Liu Jiang, Bulei Wang, Shunli Gu, Fenyan Hu, Changhao Wang, Yashao Chen
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Multidisciplinary Sciences
Changhao Wang, Qianqian Qi, Wenying Li, Jingshuang Dang, Min Hao, Shuting Lv, Xingchen Dong, Youkun Gu, Peizhe Wu, Wenyue Zhang, Yashao Chen, Joerg S. Hartig
NATURE COMMUNICATIONS
(2020)
Correction
Multidisciplinary Sciences
Changhao Wang, Qianqian Qi, Wenying Li, Jingshuang Dang, Min Hao, Shuting Lv, Xingchen Dong, Youkun Gu, Peizhe Wu, Wenyue Zhang, Yashao Chen, Jorg S. Hartig
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Nini Li, Xiaohong Ji, Somnath Mukherjee, Bing Yang, Yuqing Ren, Changhao Wang, Yashao Chen
Summary: In recent years, the adverse effects of sunscreens on the environment and biology have become a major concern. To improve sunscreen safety, researchers have developed a bionic photoprotective material, CS-SA-PDA nanosheet, by simulating the photoprotective mechanisms of skin and plant leaves. The nanosheet effectively shields against UVB and UVA, improves photostability, reduces skin permeability, and can scavenge photoinduced free radicals. It also has no skin irritation and is excellent against skin photodamage, making it an ideal skin photoprotective material.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Liu Jiang, Niuniu Qin, Shunli Gu, Wancheng Zhu, Changhao Wang, Yashao Chen
Summary: In this study, a dual-function micropatterned polypropylene (PP) surface with antifouling and antibacterial properties was successfully constructed through plasma activation, photomask technology, and ultraviolet light-induced graft polymerization. Two different micropatterning structures were prepared using antifouling and antibacterial agents, and the performance of the resulting materials was thoroughly characterized. The results showed that the dual-functional PP materials exhibited good resistance against protein and platelet adhesion, as well as high antibacterial activity.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Xingchen Dong, Zijian Yuan, Yao Qu, Yuxin Gao, Xue Pei, Qianqian Qi, Yujuan Pei, Jiaqi Li, Yashao Chen, Changhao Wang
Summary: In this study, a single nucleotide-based catalyst (ATP·Cu2+) was successfully constructed and demonstrated to catalyze enantioselective Michael reactions in aqueous media with high reactivities and good enantioselectivities up to 83% ee. The enantioselective catalytic performances of ATP·Cu2+ originate from specific binding between ATP and Cu2+ ions that exhibit both pH-dependent and temperature-dependent behaviors. The ATP·Cu2+ catalyst has been successfully applied to a wide spectrum of enone substrates and carbon nucleophiles.
Article
Chemistry, Multidisciplinary
Hongkai Wang, Weihuang Zhu, Qi Xue, Changhao Wang, Kaiqiang Liu
CHEMICAL COMMUNICATIONS
(2020)
Article
Materials Science, Biomaterials
Liu Jiang, Wancheng Zhu, Huaming Qian, Changhao Wang, Yashao Chen, Peng Liu
JOURNAL OF MATERIALS CHEMISTRY B
(2019)