Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING

Structural polymorphism of c-di-GMP bound to an EAL domain and in complex with a type II PilZ-domain protein

(2012) Ko-Hsin Chin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystallization studies of the murine c-di-GMP sensor protein STING

(2012) Yi-Che Su et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

You’ve come a long way: c-di-GMP signaling

(2012) Holger Sondermann et al.   CURRENT OPINION IN MICROBIOLOGY

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

(2012) Songying Ouyang et al.   IMMUNITY

Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING

(2012) Qian Yin et al.   MOLECULAR CELL

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

(2012) Chang Shu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis for the sensing and binding of cyclic di-GMP by STING

(2012) Yi-He Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

(2012) Guijun Shang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sensing the messenger: The diverse ways that bacteria signal through c-di-GMP

(2012) Petya Violinova Krasteva et al.   PROTEIN SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

When the PilZ don’t work: effectors for cyclic di-GMP action in bacteria

(2012) Robert P. Ryan et al.   TRENDS IN MICROBIOLOGY

The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)2at the active site

(2011) Chao-Yu Yang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses

(2011) Glen N Barber   CURRENT OPINION IN IMMUNOLOGY

Cyclic di-GMP, an established secondary messenger still speeding up

(2011) Ute Römling   ENVIRONMENTAL MICROBIOLOGY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Cytosolic surveillance and antiviral immunity

(2011) Vijay AK Rathinam et al.   Current Opinion in Virology

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Ligand-Free Open−Closed Transitions of Periplasmic Binding Proteins: The Case of Glutamine-Binding Protein

(2010) Guillermo A. Bermejo et al.   BIOCHEMISTRY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Evolutionary Origin of a Secondary Structure: π-Helices as Cryptic but Widespread Insertional Variations of α-Helices That Enhance Protein Functionality

(2010) Richard B. Cooley et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The π-helix translates structure into function

(2010) Todd M. Weaver   PROTEIN SCIENCE

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Decision-making in structure solution using Bayesian estimates of map quality: thePHENIX AutoSolwizard

(2009) Thomas C. Terwilliger et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase

(2009) Feng Rao et al.   ANALYTICAL BIOCHEMISTRY

The Cyclic Nucleotide Monophosphate Domain of Xanthomonas campestris Global Regulator Clp Defines a New Class of Cyclic Di-GMP Effectors

(2009) F. Tao et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP Allosterically Inhibits the CRP-Like Protein (Clp) of Xanthomonas axonopodis pv. citri

(2009) J. L. Leduc et al.   JOURNAL OF BACTERIOLOGY

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The cAMP Receptor-Like Protein CLP Is a Novel c-di-GMP Receptor Linking Cell–Cell Signaling to Virulence Gene Expression in Xanthomonas campestris

(2009) Ko-Hsin Chin et al.   JOURNAL OF MOLECULAR BIOLOGY

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Structural and mechanistic determinants of c-di-GMP signalling

(2009) Tilman Schirmer et al.   NATURE REVIEWS MICROBIOLOGY

Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch

(2009) Nadia Kulshina et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of ligand binding by a c-di-GMP riboswitch

(2009) Kathryn D Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Analysis of the GGDEF-EAL Domain-Containing c-di-GMP Receptor FimX

(2009) Marcos V.A.S. Navarro et al.   STRUCTURE

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE