Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases

Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives

(2011) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II

(2011) Anna Di Fiore et al.   CHEMICAL COMMUNICATIONS

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

(2011) Fabrizio Carta et al.   CHEMICAL COMMUNICATIONS

Topiramate Treatment Protects Blood-Brain Barrier Pericytes from Hyperglycemia-Induced Oxidative Damage in Diabetic Mice

(2011) Tulin O. Price et al.   ENDOCRINOLOGY

Statins for Primary Prevention of Cardiovascular and Cerebrovascular Events in Diabetic Patients without Established Cardiovascular Diseases: A Meta-Analysis

(2011) Y.-H. Chen et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Differences between Human and Rodent Pancreatic Islets

(2011) Michael J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

(In)organic anions as carbonic anhydrase inhibitors

(2011) Giuseppina De Simone et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Statins and All-Cause Mortality in High-Risk Primary Prevention

(2010) Kausik K. Ray   ARCHIVES OF INTERNAL MEDICINE

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

(2010) Fabio Pacchiano et al.   CHEMICAL COMMUNICATIONS

Effect of statin therapy on colorectal cancer

(2010) M. Bardou et al.   GUT

Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates?

(2009) Giuseppina De Simone et al.   Chemical Biology & Drug Design

The influence of concurrent anticonvulsants on the efficacy of the ketogenic diet

(2009) Peter F. Morrison et al.   EPILEPSIA

Ketogenic Diets: An Update for Child Neurologists

(2009) Eric H. Kossoff et al.   JOURNAL OF CHILD NEUROLOGY

The Coumarin-Binding Site in Carbonic Anhydrase Accommodates Structurally Diverse Inhibitors: The Antiepileptic Lacosamide As an Example and Lead Molecule for Novel Classes of Carbonic Anhydrase Inhibitors

(2009) Claudia Temperini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity

(2008) Claudiu T Supuran et al.   EXPERT OPINION ON EMERGING DRUGS

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY