期刊
JOURNAL OF GENETICS
卷 94, 期 4, 页码 591-599出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12041-015-0574-1
关键词
X chromosome; X inactivation; escape from X inactivation
资金
- National Institutes of Health [GM046883, GM113943, MH105768]
X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field.
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