Article
Chemistry, Multidisciplinary
Martin Hejda, Daniel Duvinage, Enno Lork, Antonin Lycka, Zdenck Cernosek, Jan Machacek, Sergey Makarov, Sergey Ketkov, Stefan Mebs, Libor Dostal, Jens Beckmann
Summary: The aryltellurenyl cation and the weakly coordinating carborane anion form an isolable ion pair complex, in which the Bronsted acidity of the formally hydridic B-H bonds is dramatically increased, leading to a proton transfer reaction at slightly elevated temperatures. The isolation of zwitterionic isomers further confirms the electrophilic activation of B-H bonds in the carborane moiety.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Manjur O. Akram, John R. Tidwell, Jason L. Dutton, Caleb D. Martin
Summary: The synthesis of a single site neutral Lewis superacid, tris(ortho-carboranyl)borane (BoCb(3)), was achieved in one pot from commercially available materials. It was confirmed to be a Lewis superacid due to its high fluoride ion affinity (FIA), and exhibited stronger Lewis acidity compared to widely used fluorinated aryl boranes, as evidenced by the Gutmann-Beckett method and adducts with Lewis bases. The unusually high Lewis acidity can be rationalized by the electron-withdrawing effect of ortho-carborane and lack of pi-delocalization of the LUMO. Catalytic studies demonstrated that BoCb(3) is a superior catalyst for promoting C-F bond functionalization reactions compared to tris(pentafluorophenyl)borane [B(C6F5)(3)].
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Physics, Applied
Takatoshi Yamada, Tomoaki Masuzawa, Yuki Okigawa
Summary: To enhance the carrier mobility and suppress the intrinsic carrier density of graphene on a silicon dioxide substrate, a potassium-doped nano graphene intermediate layer was introduced. Electrical properties of the fabricated graphene field-effect transistors were measured, and the results showed a shift in the Dirac point and increased carrier density and mobility. The ionized potassium atoms in the intermediate layer shielded the electric force from the negatively charged impurities, resulting in improved field-effect mobilities.
APPLIED PHYSICS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
C. Harder-Viddal, F. Heide, R. M. Roshko, J. Stetefeld
Summary: Molecular dynamics simulations were used to investigate the energetics of storage of ortho-carborane in the cavities of a nanotube, revealing a complex free energy landscape with multiple peaks and valleys related to specific architectural elements of the system. The study also assessed the activation barriers for ortho-carborane capture and release, supporting the requirements for rapid cargo uptake and tight binding to the cavities in a potential drug delivery system.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Chemistry, Organic
Gyorgyi Kovanyi-Lax, Csilla Hargitai, Peter Abranyi-Balogh, Tamas Nagy, Gabor Toth, Zsofia Garadi, Gabor Nemeth, Angela Pandur, Simon Horvath, Andras Dancso, Gyula Simig, Balazs Volk
Summary: In this study, the reactions of ortho-(pivaloylaminomethyl)benzaldehydes using boron trifluoride diethyl etherate (BF3 center dot OEt2) as the catalyst were described, and the formation of a new dimer-like keto compound and an oxoindene-type by-product was observed. Detailed characterization and theoretical calculations support the proposed mechanisms and explain the product distribution.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
G. Da Rosa, P. Maugis, A. Portavoce, S. Lartigue-Korinek, N. Valle, E. Lentzen, J. Drillet, K. Hoummada
Summary: High-resolution secondary ion mass spectrometry imaging, atom probe tomography, and transmission electron microscopy were used to investigate boron segregation at austenite grain boundaries in a high-strength steel. The study quantified the boron content in solid solution, interfacial excess at the grain boundaries, and precipitate number density after specific heat treatments. The results showed that boron distribution remains unchanged after holding at 460°C, suggesting low mobility of boron at this temperature. However, at higher temperatures (780°C and 820°C), boron distribution evolves significantly, accompanied by transient precipitation of particles at the grain boundaries.
Article
Chemistry, Physical
Zhijin Ge, Xin'ao Li, Hui Hu, Qingming Huang, Xiaohui Chen
Summary: The pure silicon MWW was synthesized for the first time using a new method and achieved complete crystallinity. Furthermore, the implantation of titanium in MWW was cleverly achieved through the use of TiCl4 acid solution treatment, leading to significantly improved conversion rate and efficiency of the catalyst.
JOURNAL OF CATALYSIS
(2023)
Article
Engineering, Environmental
Zhuquan Fu, Hao Huang, Ting Song, Shiheng Yin, Bei Long, Atif Ali, Guo-Jun Deng
Summary: In this study, a 0D/2D composite of heteroborane (xBC) confined in porous g-C3N4 nanosheets (PCN) was prepared using a facile synthesis strategy. The tight interface and shortened charge diffusion distance in the xBC-loaded PCN sample significantly promoted the separation of photoinduced carriers. Organic synthesis strategies were used to regulate the molecular structure of xBC at quantum size, which greatly affected the activation ability of boron atoms on CO2 molecules. The reduction products of 2BCN composite showed higher efficiency in converting CO2 into CH4, CO, and H-2 compared to PCN, providing insights for enhancing solar CO2 conversion by reimplanting active sites in quantum dots.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Physical
Minghui Qiu, Hao Jia, Chuntao Lan, Hongqi Liu, Shaohai Fu
Summary: In this study, an intermediate layer of sulfonate group modified boron nitride nanosheets was designed to regulate the electrochemical behavior of zinc, effectively suppressing dendrite growth and side reactions. The resulting zinc anode showed enhanced performance in aqueous zinc-ion batteries.
ENERGY STORAGE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
A. T. Matveev, K. L. Firestein, A. S. Konopatsky, I. N. Volkov, D. V. Leybo, A. P. Koskin, A. A. Vedyagin, D. V. Golberg, P. B. Sorokin, D. V. Shtansky
Summary: A new simple and scalable method for synthesizing nanocrystalline Pt-containing hexagonal boron oxynitride (Pt/BN(O)) is proposed. Pt is present only in the form of single atoms (SAs) and clusters at a minimum content of 0.0085 wt%. This sample shows high catalytic activity for CO oxidation with a specific CO2 productivity as high as 176 molCO2/gPt/h at 300 degrees C, and it retains its activity after four cycles.
Article
Chemistry, Physical
Yu Gu, Shibin Wang, Huaijie Shi, Jun Yang, Suiqin Li, Haiyang Zheng, Wenbin Jiang, Jia Liu, Xing Zhong, Jianguo Wang
Summary: The Pt-SAs/BNC catalyst, with Pt single atoms embedded in B/N codoped nanotubes, improves the electrochemical ozone production (EOP) performance by providing a rich oxygen intermediate environment, leading to a Faraday efficiency of 21% at 50 mA cm(-2). It also demonstrates significant capabilities in degrading various pesticides and antibiotics, highlighting its potential environmental applications.
Review
Materials Science, Multidisciplinary
Sneha Bhagyaraj, Mohammad A. Al-Ghouti, Peter Kasak, Igor Krupa
Summary: This review discusses the importance of boron, its contamination sources, and recent advances in boron removal methods based on adsorption. The adsorbents for deboronation are classified based on functional groups, and the reaction mechanisms of each system are comprehensively addressed, along with a summary of progress in the field over the past 5 years. Techniques for characterizing deboronation studies, suggestions for future research and applications, and possible improvements to existing systems are also presented.
EMERGENT MATERIALS
(2021)
Article
Chemistry, Physical
Qi Liu, Xinyue Xie, Mancheng Tang, Wentao Tao, Ting Shi, Yuanzhen Zhang, Tingting Huang, Yilei Zhao, Zixin Deng, Shuangjun Lin
Summary: A highly stereoselective enzymatic one-pot reaction was established for the synthesis of an aminodiol intermediate of florfenicol, facilitating the development of a chemoenzymatic method for producing florfenicol.
Article
Chemistry, Physical
Ah-Hyun Park, Tae-Hoon Seo
Summary: This study introduces the development of gallium nitride (GaN) layers using graphene and hexagonal boron nitride (h-BN) as intermediary substrates. The results show that GaN can be successfully grown on h-BN with a uniformly smooth surface morphology. However, the crystallinity of GaN grown on h-BN is inferior to that of GaN grown on conventional GaN, as confirmed by photoluminescence spectroscopy and X-ray diffraction. Nevertheless, the practical applicability of the GaN layer grown on h-BN is validated through the successful fabrication and operation of an NUV-LED device.
Article
Chemistry, Inorganic & Nuclear
Hideki Sugimoto, Kurumi Aoki, Mayuko Miyanishi, Yoshihito Shiota, Kazunari Yoshizawa, Shinobu Itoh
Summary: A cyclometalated osmium(III) complex, [(OsCl)ClIII(phpy)(tpy)]+ (OsIII(phpy); phpy = 2-C6H4-2'-C5H4N-kappa C,N), was synthesized and further studied for its chemical properties by reaction with different oxidants, leading to the formation of an organometallic oxido-osmium(V) complex capable of exchanging oxygen atoms.
Article
Biochemistry & Molecular Biology
Matthew G. McDonald, Catherine K. Yeung, Aaron M. Teitelbaum, Amanda L. Johnson, Shinya Fujii, Hiroyuki Kagechika, Allan E. Rettie
JOURNAL OF LIPID RESEARCH
(2019)
Article
Chemistry, Organic
Ko Urushibara, Tatsunori Yamada, Akihiro Yokoyama, Hirotoshi Mori, Hyuma Masu, Isao Azumaya, Hiroyuki Kagechika, Tsutomu Yokozawa, Aya Tanatani
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Hitomi Koga, Mai Negishi, Marie Kinoshita, Shinya Fujii, Shuichi Mori, Mari Ishigami-Yuasa, Emiko Kawachi, Hiroyuki Kagechika, Aya Tanatani
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Medicinal
Shinya Fujii, Eriko Kikuchi, Yuko Watanabe, Honoka Suzuyama, Mari Ishigami-Yuasa, Takayasu Mori, Kiyoshi Isobe, Shinichi Uchida, Hiroyuki Kagechika
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Organic
Daiki Kato, Takuya Shiraishi, Hiroyuki Kagechika, Tomoya Hirano
Summary: Coumarin serves as a core structure for photofunctional molecules, offering regulatory functionality for fluorescent sensors and photoremovable protecting groups. The study demonstrates that the 6-arylcoumarin moiety can provide a multi-functional regulatory property, showing OFF-ON-OFF change in response to different pH values.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Maiko Arimura, Kimiko Tanaka, Midori Kanda, Ko Urushibara, Shinya Fujii, Kosuke Katagiri, Isao Azumaya, Hiroyuki Kagechika, Aya Tanatani
Summary: The study synthesized N,N'-dimethylated oligosquaramides, which exhibit folded structures in the crystalline state and retain well-ordered folded structures in solution. These compounds have unique steric and electronic properties that can provide access to novel functional aromatic multilayered and helical foldamers.
Article
Chemistry, Medicinal
Shinya Fujii, Takahiro Miura, Tsuyoshi Oikawa, Xian-Yang Qin, Soichi Kojima, Hiroyuki Kagechika
Summary: In this study, a series of phthalazine-1,4-dione-based menaquinone analogs were designed and synthesized, with compounds bearing intact isoprene chain showing selective antiproliferative activity towards HCC cell line JHH7. The geranyl derivative 10 exhibited submicromolar potency, indicating its potential as a promising lead compound for anticancer agents.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Shinya Fujii, Eriko Kikuchi, Honoka Suzuyama, Yuko Watanabe, Mari Ishigami-Yuasa, Hiroyuki Masuno, Takayasu Mori, Kiyoshi Isobe, Shinichi Uchida, Hiroyuki Kagechika
Summary: Hypertension is a crucial target for drug discovery, with a focus on the WNK-OSR1/SPAK-NCC signaling cascade. Through a screening system, the study investigated the structure-activity relationship of salicylanilide derivatives as SPAK kinase inhibitors. Compound 10 a was identified as a potent SPAK inhibitor with reduced toxicity, showing promising potential for a new class of antihypertensive drugs.
Article
Biochemistry & Molecular Biology
Ayana Yoshihara, Haru Kawasaki, Hiroyuki Masuno, Koki Takada, Nobutaka Numoto, Nobutoshi Ito, Naoya Hirata, Yasunari Kanda, Michiyasu Ishizawa, Makoto Makishima, Hiroyuki Kagechika, Aya Tanatani
Summary: This study synthesized amide derivatives of lithocholic acid derivative 3 and found that N-cyanoamide 6 is more active than 1 and 3.
Article
Chemistry, Medicinal
Tsuyoshi Oikawa, Shinya Fujii, Shuichi Mori, Hiroyuki Masuno, Emiko Kawachi, Hiroyuki Kagechika
Summary: A series of retinobenzoic acids were synthesized to investigate the structure-activity relationship of retinoids at the hydrophobic moiety. Compound 24c with a t-butyldimethylsilyl group showed potent retinoid activity, especially towards RARγ. This study provides insights for the development of new RARγ ligands.
Article
Chemistry, Organic
Shuichi Mori, Nozomi Tsuemoto, Emiko Kawachi, Chiharu Takubo, Aya Tanatani, Hiroyuki Kagechika
Summary: In this study, novel retinoids containing a trans-SF4-alkynyl group as a structural element were designed and synthesized. The compounds showed antagonistic activity towards retinoid acid receptors (RARs) and altered the binding mode of RARα ligand-binding domain.
Article
Biochemistry & Molecular Biology
Jennifer Nhieu, Liming Milbauer, Thomas Lerdall, Fatimah Najjar, Chin-Wen Wei, Ryosuke Ishida, Yue Ma, Hiroyuki Kagechika, Li-Na Wei
Summary: All-trans-retinoic Acid (atRA), derived from Vitamin A, plays crucial roles in various biological processes. It can modulate gene expression through nuclear RA receptors (RARs) or regulate cytoplasmic kinase signaling via cellular retinoic acid binding protein 1 (CRABP1). This study focuses on identifying CRABP1-binding ligands without RAR activity for potential therapeutic applications. The researchers developed a P19-MN differentiation system to investigate the effects of CRABP1 ligands in motor neuron (MN) differentiation and discovered C32 and C4 as CRABP1 ligands that can modulate CaMKII activation and protect against excitotoxicity-triggered MN death. These findings suggest the potential of selective and CRABP1-binding ligands in mitigating MN degenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Kimiko Tanaka, Fumi Takeda, Midori Kanda, Masatoshi Kawahata, Shinya Fujii, Kosuke Katagiri, Hyuma Masu, Hiroyuki Kagechika, Aya Tanatani
Summary: This study found that the crystal structure of aromatic N-monomethylsquaramide is in the (trans, cis) form, but in solution, it exhibits a solvent-dependent conformational equilibrium. Therefore, aromatic N-monomethylsquaramides could be used as components of environmentally responsive molecular switches.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jason P. Mansell, Aya Tanatani, Hiroyuki Kagechika
Summary: The combination of the new VDR agonist LCA-150 with LPA has synergistic effects on promoting osteoblast maturation, surpassing the efficacy of vitamin D.
Article
Biochemistry & Molecular Biology
Erika Cione, Maria Cristina Caroleo, Hiroyuki Kagechika, Fabrizio Manetti
Summary: A classical drug repurposing approach was used to identify potential allosteric binders for GPR40, with three prioritised compounds showing significant effects on insulin secretion and breast cancer growth activities. These new GPR40 modulators could be promising tools for therapeutic intervention in type 2 diabetes.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
