Prodrugs Design Based on Inter- and Intramolecular Chemical Processes

The future of prodrugs – design by quantum mechanics methods

(2013) Rafik Karaman et al.   Expert Opinion on Drug Delivery

Prodrugs for masking bitter taste of antibacterial drugs—a computational approach

(2013) Rafik Karaman   JOURNAL OF MOLECULAR MODELING

Computationally-designed phenylephrine prodrugs – a model for enhancing bioavailability

(2013) Rafik Karaman et al.   MOLECULAR PHYSICS

Prodrugs of Acyclovir - A Computational Approach

(2012) Rafik Karaman et al.   Chemical Biology & Drug Design

Targeted prodrugs in oral drug delivery: the modern molecular biopharmaceutical approach

(2012) Arik Dahan et al.   Expert Opinion on Drug Delivery

Prodrugs of fumarate esters for the treatment of psoriasis and multiple sclerosis—a computational approach

(2012) Rafik Karaman et al.   JOURNAL OF MOLECULAR MODELING

Computational-Aided Design for Dopamine Prodrugs Based on Novel Chemical Approach

(2011) Rafik Karaman   Chemical Biology & Drug Design

Molecular biology of mammalian bitter taste receptors. A review.

(2011) Wolfgang Meyerhof et al.   FLAVOUR AND FRAGRANCE JOURNAL

Computer-assisted design for paracetamol masking bitter taste prodrugs

(2011) Hatem Hejaz et al.   JOURNAL OF MOLECULAR MODELING

Computer-assisted design for atenolol prodrugs for the use in aqueous formulations

(2011) Rafik Karaman et al.   JOURNAL OF MOLECULAR MODELING

Prodrugs--from Serendipity to Rational Design

(2011) K. M. Huttunen et al.   PHARMACOLOGICAL REVIEWS

Analyzing the efficiency in intramolecular amide hydrolysis of Kirby’s N-alkylmaleamic acids – A computational approach

(2011) Rafik Karaman   Computational and Theoretical Chemistry

The role of proximity orientation in intramolecular proton transfer reactions

(2011) Rafik Karaman   Computational and Theoretical Chemistry

The effective molarity (EM) – A computational approach

(2010) Rafik Karaman   BIOORGANIC CHEMISTRY

Research Article: Computer-Assisted Design of Pro-drugs for Antimalarial Atovaquone

(2010) Rafik Karaman et al.   Chemical Biology & Drug Design

Prodrugs of aza nucleosides based on proton transfer reaction

(2010) Rafik Karaman   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Prodrugs: Some Thoughts and Current Issues

(2010) Valentino J. Stella   JOURNAL OF PHARMACEUTICAL SCIENCES

Proximity vs. strain in intramolecular ring-closing reactions

(2010) Rafik Karaman   MOLECULAR PHYSICS

Tranexamic Acid Treatment for Heavy Menstrual Bleeding

(2010) Andrea S. Lukes et al.   OBSTETRICS AND GYNECOLOGY

A computational analysis of intramolecularity in proton transfer reactions

(2010) Rafik Karaman et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The efficiency of proton transfer in Kirby’s enzyme model, a computational approach

(2010) Rafik Karaman   TETRAHEDRON LETTERS

A general equation correlating intramolecular rates with ‘attack’ parameters: distance and angle

(2010) Rafik Karaman   TETRAHEDRON LETTERS

Analyzing the efficiency of proton transfer to carbon in Kirby’s enzyme model—a computational approach

(2010) Rafik Karaman   TETRAHEDRON LETTERS

Identification of the Key Bitter Compounds in Our Daily Diet Is a Prerequisite for the Understanding of the hTAS2R Gene Polymorphisms Affecting Food Choice

(2009) Thomas Hofmann   Annals of the New York Academy of Sciences

The effective molarity (EM) puzzle in proton transfer reactions

(2009) Rafik Karaman   BIOORGANIC CHEMISTRY

Shifting suitability for malaria vectors across Africa with warming climates

(2009) A Townsend Peterson   BMC INFECTIOUS DISEASES

Bitter peptides and bitter taste receptors

(2009) K. Maehashi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prodrug Approaches for Enhancing the Bioavailability of Drugs with Low Solubility

(2009) Christa E. Müller   CHEMISTRY & BIODIVERSITY

A Singularity Model for Chemical Reactivity

(2009) Fredric M. Menger et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cleavage of Menger’s aliphatic amide: A model for peptidase enzyme solely explained by proximity orientation in intramolecular proton transfer

(2009) Rafik Karaman   JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM

Effects of substitution on the effective molarity (EM) for five membered ring-closure reactions – A computational approach

(2009) Rafik Karaman   JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM

The effective molarity (EM) puzzle in intramolecular ring-closing reactions

(2009) Rafik Karaman   JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM

Pharmacokinetics and Pharmacodynamics of Prasugrel, a Thienopyridine P2Y12 Inhibitor

(2009) Paul P Dobesh   PHARMACOTHERAPY

Analyzing Kirby’s amine olefin—a model for amino acid ammonia lyases

(2009) Rafik Karaman   TETRAHEDRON LETTERS

The gem-disubstituent effect—a computational study that exposes the relevance of existing theoretical models

(2009) Rafik Karaman   TETRAHEDRON LETTERS

A new mathematical equation relating activation energy to bond angle and distance: A key for understanding the role of acceleration in lactonization of the trimethyl lock system

(2008) Rafik Karaman   BIOORGANIC CHEMISTRY

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

(2008) Eva M. del Amo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B

(2008) K. Raja Reddy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prodrugs for the Treatment of Neglected Diseases

(2008) Man Chung et al.   MOLECULES

Prodrugs for Amines

(2008) Ana Simplício et al.   MOLECULES

Analysis of Menger’s ‘spatiotemporal hypothesis’

(2008) Rafik Karaman   TETRAHEDRON LETTERS

Reevaluation of Bruice’s proximity orientation

(2008) Rafik Karaman   TETRAHEDRON LETTERS

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting

(2007) Fujun Li et al.   JOURNAL OF PHARMACEUTICAL SCIENCES