Quantitative Determination of Cellular Farnesyltransferase Activity: Towards Defining the Minimum Substrate Reactivity for Biologically Relevant Protein Farnesylation

A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins

(2014) Charuta C. Palsuledesai et al.   Molecular BioSystems

Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform

(2013) G. Charron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Protein Prenylation in Progeria

(2013) S. G. Young et al.   Science Translational Medicine

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Expansion of Protein Farnesyltransferase Specificity Using “Tunable” Active Site Interactions

(2012) James L. Hougland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Consequences of a Single Gene Mutation in a Colorectal Cancer Model

(2011) Patrick J. Halvey et al.   JOURNAL OF PROTEOME RESEARCH

Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors

(2011) Norbert Berndt et al.   Nature Protocols

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ras trafficking, localization and compartmentalized signalling

(2011) Ian A. Prior et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

S-Farnesyl-Thiopropionic Acid Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase

(2011) Joel A. Bergman et al.   ACS Medicinal Chemistry Letters

Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity

(2011) Nir London et al.   PLoS Computational Biology

Evaluation of Alkyne-Modified Isoprenoids as Chemical Reporters of Protein Prenylation

(2010) Amanda J. DeGraw et al.   Chemical Biology & Drug Design

A Tagging-via-substrate Approach to Detect the Farnesylated Proteome Using Two-dimensional Electrophoresis Coupled with Western Blotting

(2010) Fredrick O. Onono et al.   MOLECULAR & CELLULAR PROTEOMICS

Alkynyl-farnesol reporters for detection ofproteinS-prenylation in cells

(2010) Guillaume Charron et al.   Molecular BioSystems

Systematic Comparison of Constitutive Promoters and the Doxycycline-Inducible Promoter

(2010) Jane Yuxia Qin et al.   PLoS One

Context-Dependent Substrate Recognition by Protein Farnesyltransferase†

(2009) James L. Hougland et al.   BIOCHEMISTRY

A novel approach to tag and identify geranylgeranylated proteins

(2009) Lai N. Chan et al.   ELECTROPHORESIS

Identification of Novel Peptide Substrates for Protein Farnesyltransferase Reveals Two Substrate Classes with Distinct Sequence Selectivities

(2009) James L. Hougland et al.   JOURNAL OF MOLECULAR BIOLOGY

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

(2009) Uyen T T Nguyen et al.   Nature Chemical Biology

Farnesyltransferase Inhibitors: A Detailed Chemical View on an Elusive Biological Problem

(2008) Sergio Sousa et al.   CURRENT MEDICINAL CHEMISTRY

Rho Family GTPase Modification and Dependence on CAAXMotif-signaled Posttranslational Modification

(2008) Patrick J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY