4.7 Article

Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 4, Pages 625-627

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b918964e

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Funding

  1. Italian Ministry of Scientific Research
  2. AIRC
  3. FVG
  4. Swiss National Science Foundation [116868]
  5. Dr Helmut Legerlotz Stiftung
  6. University of Zurich

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Guanidino-modified phthalocyanines are evaluated in vitro (polymerase-stop assays and FRET) and in cultured cells as G4-DNA ligands and modulators of gene transcription.

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