Article
Pharmacology & Pharmacy
Changzhi Zhao, Congshu Xiao, Songqiao Feng, Jianxin Bai
Summary: In this study, we discovered a new approach to alleviate liver damage caused by severe septic shock by controlling a form of controlled cell death called ferroptosis. We found that artemisitene (ATT) significantly reduced liver damage and ferroptotic characteristics. Additionally, ATT reduced the expression of the nuclear factor-κB (NF-κB) subunit to reduce LPS-induced hepatic oxidative stress and inflammation, and upregulated the expression of the nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) and its downstream protein heme oxygenase 1 (HO-1).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
So-Ra Kim, Kyung-Joo Seong, Won-Jae Kim, Ji-Yeon Jung
Summary: EGCG protects microglia from hypoxia-induced inflammation and oxidative stress through inhibition of the NF-κB pathway and activation of the Nrf-2/HO-1 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Hao Huang, Jian Wang, Shaik Althaf Hussain, Venkata Subba Reddy Gangireddygari, Yingying Fan
Summary: This study aimed to investigate the preventive effect of gossypin against LPS-induced lung inflammation and explore the underlying mechanism. Rats were orally administered different doses of gossypin and various parameters were measured. The results showed that gossypin significantly reduced lung tissue wet to dry weight ratio, inflammatory cells, total protein, macrophages, and neutrophils in bronchoalveolar lavage fluid. Gossypin also affected the levels of inflammatory cytokines, antioxidants, and inflammatory parameters, as well as Nrf2 and HO-1 expression. The findings suggest that gossypin can improve the severity of ALI by enhancing lung tissue integrity, decreasing alveolar wall thickness, reducing pulmonary interstitial edema and inflammatory cell infiltration.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chenghao Ren, Jie Jin, Wei Hu, Qi Chen, Jian Yang, Yaosen Wu, Yifei Zhou, Liaojun Sun, Weiyang Gao, Xiaolei Zhang, Naifeng Tian
Summary: The study showed that betulin can suppress inflammation induced by IL-1 beta and alleviate cartilage inflammation, acting through the activation of the AKT/Nrf2 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jae Kwang Kim, Hye Jin Yang, Younghoon Go
Summary: Quercus acuta Thunb. extract shows significant anti-neuroinflammatory effects by inhibiting NF-kappa B and MAPK activation, and activating Nrf2/HO-1 signaling pathways, suggesting its potential in preventing microglia-mediated neuroinflammation.
Article
Medicine, Research & Experimental
Xiaoyu Zhang, Yuan Kang, Ximeng Li, Yunfeng Huang, Ruijuan Qi, Yixin Han, Runlan Cai, Yuan Gao, Yun Qi
Summary: Potentilla discolor Bunge (PD) is a traditional Chinese medicine with strong anti-inflammatory effects by suppressing the expressions of iNOS, TNF-α, and MCP-1, as well as inhibiting the activation of NF-kappa B and AP-1. The ethanol extract of the whole herbs of PD (EPD) shows promising therapeutic potential for inflammatory diseases, especially intestinal inflammation, through its ability to modulate inflammatory mediators and signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Shujuan Li, Yan Li, Li Hou, Li Tang, Fang Gao
Summary: Forsythoside B hampers IL-1 beta-elicited rat chondrocyte apoptosis, oxidative stress, and facilitates proliferation. It suppresses the profiles of inflammatory factors and NOD-like receptor family pyrin domain containing 3 inflammasomes, as well as Kelch-like epichlorohydrin-associated protein-1 (Keap1) and nuclear factor-kappa B (NF-kappa B) phosphorylation, while promotes nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels. Furthermore, Forsythoside B mitigates cartilage damage and degeneration.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shih-Ming Ou, Yin-Chieh Hsu, Shu-Ling Fu, Lie-Chwen Lin, Chao-Hsiung Lin
Summary: Galgravin has anti-inflammatory effects, it can suppress NF-kappa B activation and reduce the expression of proinflammatory molecules, suggesting its potential application in inflammation diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Weiwei Zhu, Wu Luo, Jibo Han, Qiuyan Zhang, Lijun Ji, Aleksandr V. Samorodov, Valentin N. Pavlov, Zaishou Zhuang, Daona Yang, Lina Yin, Lijiang Huang, Guang Liang, Joo Young Huh, Yi Wang
Summary: This study investigated the anti-inflammatory mechanism of Schisandrin B (Sch B) in macrophages and an animal model of acute lung injury (ALI) and found that Sch B directly binds to MyD88 to regulate inflammatory responses and inhibit the expression of inflammatory factors. The study suggests that Sch B has therapeutic potential for ALI and other MyD88-dependent inflammatory diseases.
Article
Food Science & Technology
Xiaoyu Bao, Jianping Wu
Summary: Ovomucin hydrolysate has been shown to prevent pathogen adhesion to intestinal epithelial cells, and in this study, it was demonstrated to improve intestinal barrier integrity by inhibiting inflammatory responses induced by LPS.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Yan-yan Yu, Xiang-qian Li, Wen-peng Hu, Shi-chao Cu, Jia-jia Dai, Ya-nan Gao, Yi-ting Zhang, Xiao-yi Bai, Da-yong Shi
Summary: The NF-kappa B inhibitor 270 showed anti-inflammatory effects in LPS-induced AKI and ALI, improving pathological changes, reducing pro-inflammation gene expression, blocking NF-kappa B and JNK pathway activation, attenuating oxidative stress and autophagy inhibition, and reducing inflammation markers in plasma.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Kanittha Chantarasakha, Thiti Asawapanumas, Rinrada Suntivich, Atikorn Panya, Natthaporn Phonsatta, Parameth Thiennimitr, Kobkul Laoteng, Surapun Tepaamorndech
Summary: This study demonstrated the anti-inflammatory potential and mechanism of Hatakabb herbal extract, with pyrogallol identified as a novel mediator inhibiting LPS-induced inflammation.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Plant Sciences
Xiaomei Duan, Jun Li, Jingxue Cui, Yuwei Dong, Xuelei Xin, Haji Akber Aisa
Summary: The study aimed to clarify the anti-inflammatory activity of Anchusa italica, reveal its molecular mechanisms, and discover the active anti-inflammatory ingredients.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Yun Jung Lee, Yong Pyo Lee, Chang Seob Seo, Eun Sik Choi, Byung Hyuk Han, Jung Joo Yoon, Se Hoon Jang, Chae Ghang Jeong, Yeun Ja Mun, Dae Gill Kang, Ho Sub Lee
Summary: The ethanol extract of Carthamus tinctorius L. (ECT) can alleviate vascular inflammatory processes by reducing cell adhesion molecules and oxidative stress, inhibiting NF-kappa B activation, and regulating the Nrf-2/HO-1 signaling axis. Further research is needed to determine the specific compound responsible for protecting against vascular diseases.
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)