Article
Pharmacology & Pharmacy
Yen-Chang Chen, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Teng Wu, Miao-Hsiang Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: The study found that nicardipine can inhibit the migration and colony formation of breast cancer cells, and increase the expression of Nrf2 and HO-1. The reduction of matrix metalloproteinase-9 by nicardipine is regulated by Nrf2/HO-1 axis and its catalytic end products.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Review
Biochemistry & Molecular Biology
Zhenwei Xia, Wenwei Zhong
Summary: HO-1 plays a crucial immunoregulatory role in asthmatic airway inflammation by regulating various immune cells and exerting anti-inflammatory effects.
Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi
Summary: Oxidative stresses play a pivotal role in various pathophysiological conditions. The Keap1/Nrf2 pathway is a dual-edged sword with beneficial effects on both normal and cancer cells by regulating endogenous antioxidant enzymes. Targeting the Nrf2/HO-1 axis is considered a novel strategy for cancer treatment, especially in lung cancer.
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Zhongyang Lv, Xingquan Xu, Ziying Sun, Yannick Xiaofan Yang, Hu Guo, Jiawei Li, Kuoyang Sun, Rui Wu, Jia Xu, Qing Jiang, Shiro Ikegawa, Dongquan Shi
Summary: The study demonstrates that TRPV1 inhibits M1 macrophage polarization in synovium, thereby reducing synovitis and attenuating the progression of osteoarthritis.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Jiawen Yang, Jiajie Mo, Juji Dai, Chenqiao Ye, Wei Cen, Xuzhi Zheng, Lei Jiang, Lechi Ye
Summary: This study demonstrates that cetuximab enhances the cytotoxic effect of RSL3 on KRAS mutant CRC cells by regulating the p38/Nrf2/HO-1 axis to promote ferroptosis. These findings suggest a potential strategy to overcome drug resistance in KRAS mutant colorectal cancer.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Daiana Sapochnik, Ana R. Raimondi, Victoria Medina, Julian Naipauer, Enrique A. Mesri, Omar Coso
Summary: Kaposi's sarcoma (KS) is a common tumor in AIDS patients, caused by KSHV virus infection. Research has found that the intracellular signaling molecule Nrf2 plays an important role in the development of KS in infected cells. Nrf2 regulates the expression of the HO-1 gene and is involved in tumor formation. Therefore, Nrf2 or its associated proteins may be potential therapeutic targets for KS.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Ayelen Toro, Nicolas Anselmino, Claudia Solari, Marcos Francia, Camila Oses, Pablo Sanchis, Juan Bizzotto, Camila Vazquez Echegaray, Maria Victoria Petrone, Valeria Levi, Elba Vazquez, Alejandra Guberman
Summary: The study reveals an interaction between p53 and HO-1 in ES cells, with p53 playing a crucial role in regulating HO-1 protein stability and possibly strengthening antioxidant mechanisms in the absence of p53.
Article
Oncology
Rui Li, Xin Zeng, Meihua Yang, Xiaohui Xu, Jinmei Feng, Liming Bao, Bingqian Xue, Xin Wang, Yi Huang
Summary: The study found that DPP-4i may accelerate murine breast cancer metastasis by promoting an oncogenic ROS-NRF2-HO-1 axis, inducing aberrant oxidative stress through ROS overproduction. Therefore, this research not only reveals the oncogenic role of DPP-4i in breast cancer progression but also provides a new strategy to alleviate the adverse effects of DPP-4i by targeting HO-1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eniko Balogh, Arpan Chowdhury, Haneen Ababneh, David Mate Csiki, Andrea Toth, Viktoria Jeney
Summary: Calcific aortic valve stenosis (CAVS) is characterized by fibro-calcific remodeling of the aortic valves, and activation of the Nrf2/HO-1 pathway inhibits VIC calcification. This study demonstrates that heme-induced Nrf2/HO-1 expression in VICs inhibits calcification, attributing this effect to the end products generated by HO-1-mediated heme degradation and ferritin.
Article
Endocrinology & Metabolism
Xinfeng Zhou, Yijian Zhang, Mingzhuang Hou, Hao Liu, Huilin Yang, Xi Chen, Tao Liu, Fan He, Xuesong Zhu
Summary: Melatonin enhances NRF2 protein levels by inhibiting miR-146a, improving early-stage osteoarthritis cartilage degradation, and holds therapeutic potential.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Cheol Park, Hee-Jae Cha, Da Hye Kim, Chan -Young Kwon, Shin-Hyung Park, Su Hyun Hong, EunJin Bang, Jaehun Cheong, Gi-Young Kim, Yung Hyun Choi
Summary: The study aimed to investigate the protective efficacy of fisetin on H2O2-induced oxidative damage in C2C12 murine myoblasts. The results showed that fisetin significantly weakened H2O2-induced cell viability inhibition, DNA damage, and ROS generation. Fisetin also alleviated cell cycle arrest and apoptosis induced by H2O2, while increasing the Bcl-2/Bax ratio and attenuating mitochondrial damage. Furthermore, fisetin-induced activation of Nrf2 and HO-1 was found to be important for its protective effects. However, inhibiting HO-1 activity greatly offset the protective efficacy of fisetin.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei -Chun Chen, Chung-Hao Huang, Wangta Liu, Jin-Ching Lee
Summary: Dengue virus (DENV) infection is a life-threatening disease with no effective treatment options. However, a study found that sulforaphane (SFN) has significant antiviral activity against DENV by inducing heme oxygenase-1 (HO-1) expression and inhibiting viral protease activity. This suggests that SFN could be a promising candidate for treating DENV.
ANTIVIRAL RESEARCH
(2022)
Meeting Abstract
Oncology
Bethany N. Hannafon, Karla Carpenter, William Berry, Ralf Janknecht, William Dooley, Wei-Qun Ding
Article
Biochemistry & Molecular Biology
Shuyu Zhang, Jing Xue, Jie Zheng, Shuai Wang, Jundong Zhou, Yang Jiao, Yangyang Geng, Jinchang Wu, Bethany N. Hannafon, Wei-Qun Ding
FREE RADICAL BIOLOGY AND MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Bethany N. Hannafon, Karla J. Carpenter, William L. Berry, Ralf Janknecht, William C. Dooley, Wei-Qun Ding
Article
Multidisciplinary Sciences
Shuai Wang, Bethany N. Hannafon, Stuart E. Lind, Wei-Qun Ding
Review
Oncology
Yang Jiao, Bethany N. Hannafon, Wei-Qun Ding
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2016)
Article
Oncology
Yi-Fan Xu, Bethany N. Hannafon, Yan D. Zhao, Russell G. Postier, Wei-Qun Ding
Review
Pathology
Bethany N. Hannafon, Wei-Qun Ding
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Bethany N. Hannafon, Wei-Qun Ding
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2013)
Article
Biochemistry & Molecular Biology
Shuai Wang, Bethany N. Hannafon, Roman F. Wolf, Jundong Zhou, Jori E. Avery, Jinchang Wu, Stuart E. Lind, Wei-Qun Ding
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2014)
Article
Multidisciplinary Sciences
Jing Xue, Amanda Moyer, Bing Peng, Jinchang Wu, Bethany N. Hannafon, Wei-Qun Ding
Article
Oncology
Yang Jiao, Tanya Watts, Jing Xue, Bethany Hannafon, Wei-Qun Ding
Article
Cell Biology
Bethany N. Hannafon, Amy L. Gin, Yi-Fan Xu, Matthew Bruns, Cameron L. Calloway, Wei-Qun Ding
CELL COMMUNICATION AND SIGNALING
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Bethany N. Hannafon, Katy Gaskill, Cameron Calloway, Wei-Qun Ding
Article
Oncology
Yang Jiao, Bethany N. Hannafon, Roy R. Zhang, Kar-Ming Fung, Wei-Qun Ding
Article
Oncology
Bethany N. Hannafon, Yvonne D. Trigoso, Cameron L. Calloway, Y. Daniel Zhao, David H. Lum, Alana L. Welm, Zhizhuang J. Zhao, Kenneth E. Blick, William C. Dooley, W. Q. Ding
BREAST CANCER RESEARCH
(2016)