Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis

Cross-Tolerization between Nod1 and Nod2 Signaling Results in Reduced Refractoriness to Bacterial Infection in Nod2-Deficient Macrophages

(2014) Y.-G. Kim et al.   JOURNAL OF IMMUNOLOGY

 -PIX and Rac1 GTPase Mediate Trafficking and Negative Regulation of NOD2

(2014) J. Eitel et al.   JOURNAL OF IMMUNOLOGY

Nod2-Dependent Th2 Polarization of Antigen-Specific Immunity

(2014) J. G. Magalhaes et al.   JOURNAL OF IMMUNOLOGY

Regulation of innate and adaptive immunity by the commensal microbiota

(2011) Irene Jarchum et al.   CURRENT OPINION IN IMMUNOLOGY

Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands

(2011) Joao G. Magalhaes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Solute Carrier Family 15A4 Regulates TLR9 and NOD1 Functions in the Innate Immune System and Promotes Colitis in Mice

(2011) Shigemi Sasawatari et al.   GASTROENTEROLOGY

Nod2 is essential for temporal development of intestinal microbial communities

(2011) A. Rehman et al.   GUT

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

(2011) E. M. Fernandez et al.   GUT

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Signaling via the RIP2 Adaptor Protein in Central Nervous System-Infiltrating Dendritic Cells Promotes Inflammation and Autoimmunity

(2011) Patrick J. Shaw et al.   IMMUNITY

Autophagy in immunity and cell-autonomous defense against intracellular microbes

(2011) Vojo Deretic   IMMUNOLOGICAL REVIEWS

NOD-Like Receptor Activation by Outer Membrane Vesicles fromVibrio choleraeNon-O1 Non-O139 Strains Is Modulated by the Quorum-Sensing Regulator HapR

(2011) H. Bielig et al.   INFECTION AND IMMUNITY

Nucleotide-Binding Oligomerization Domain 1 Mediates Recognition of Clostridium difficile and Induces Neutrophil Recruitment and Protection against the Pathogen

(2011) M. Hasegawa et al.   JOURNAL OF IMMUNOLOGY

Non-apoptotic role of BID in inflammation and innate immunity

(2011) Garabet Yeretssian et al.   NATURE

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

(2011) Kaoru Geddes et al.   NATURE MEDICINE

Bacterial cell wall assembly: still an attractive antibacterial target

(2011) Timothy D.H. Bugg et al.   TRENDS IN BIOTECHNOLOGY

The role of infections in the pathogenesis and course of multiple sclerosis

(2010) Siddharama Pawate et al.   Annals of Indian Academy of Neurology

Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages

(2010) L Moreno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Peptidoglycan Recognition Proteins Protect Mice from Experimental Colitis by Promoting Normal Gut Flora and Preventing Induction of Interferon-γ

(2010) Sukumar Saha et al.   Cell Host & Microbe

Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity

(2010) Heiko Mühl et al.   CELLULAR MICROBIOLOGY

NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages

(2010) Michelle N. Brooks et al.   CELLULAR MICROBIOLOGY

New insights into the generation of Th2 immunity and potential therapeutic targets for the treatment of asthma

(2010) Gerard E Kaiko et al.   Current Opinion in Allergy and Clinical Immunology

Nod-like receptors: sentinels at host membranes

(2010) Dana J Philpott et al.   CURRENT OPINION IN IMMUNOLOGY

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses

(2010) J. T. Tigno-Aranjuez et al.   GENES & DEVELOPMENT

Nod1 and Nod2 Regulation of Inflammation in the Salmonella Colitis Model

(2010) K. Geddes et al.   INFECTION AND IMMUNITY

Helicobacter pylori Exploits Cholesterol-Rich Microdomains for Induction of NF- B-Dependent Responses and Peptidoglycan Delivery in Epithelial Cells

(2010) M. L. Hutton et al.   INFECTION AND IMMUNITY

Review: Mammalian peptidoglycan recognition proteins (PGRPs) in innate immunity

(2010) Roman Dziarski et al.   Innate Immunity

Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC

(2010) S. Kurata   INTERNATIONAL IMMUNOLOGY

Innate signals from Nod2 block respiratory tolerance and program TH2-driven allergic inflammation

(2010) Wei Duan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses

(2010) Jill M. Marinis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocytes express functional NOD1 and NOD2 receptors: A role for NOD1 in hepatocyte CC and CXC chemokine production

(2010) Melanie J. Scott et al.   JOURNAL OF HEPATOLOGY

The Pathogen Recognition Receptor NOD2 Regulates Human FOXP3+ T Cell Survival

(2010) M. K. Rahman et al.   JOURNAL OF IMMUNOLOGY

Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes

(2010) C U Duerr et al.   Mucosal Immunology

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

(2010) Steven A. Saenz et al.   NATURE

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Regulation of the expression of inducible nitric oxide synthase

(2010) Andrea Pautz et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Autophagy and innate immunity: Triggering, targeting and tuning

(2010) Rhea Sumpter et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Innate immune cell populations function as initiators and effectors in Th2 cytokine responses

(2010) Steven A. Saenz et al.   TRENDS IN IMMUNOLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

PGLYRP-2 and Nod2 Are Both Required for Peptidoglycan-Induced Arthritis and Local Inflammation

(2009) Sukumar Saha et al.   Cell Host & Microbe

Autophagy Induction by the Pathogen Receptor CD46

(2009) Pierre-Emmanuel Joubert et al.   Cell Host & Microbe

Internalization-dependent recognition ofMycobacterium aviumssp.paratuberculosisby intestinal epithelial cells

(2009) Johanna Pott et al.   CELLULAR MICROBIOLOGY

The innate immune molecule, NOD1, regulates direct killing ofHelicobacter pyloriby antimicrobial peptides

(2009) Alexandra Grubman et al.   CELLULAR MICROBIOLOGY

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

(2009) Maria Kaparakis et al.   CELLULAR MICROBIOLOGY

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

(2009) MingFang Tao et al.   CURRENT BIOLOGY

Erbin and the NF2 Tumor Suppressor Merlin Cooperatively Regulate Cell-Type-Specific Activation of PAK2 by TGF-β

(2009) Mark C. Wilkes et al.   DEVELOPMENTAL CELL

Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches

(2009) F. Barreau et al.   GUT

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

(2009) Mathieu J.M. Bertrand et al.   IMMUNITY

Role of Nod1 in Mucosal Dendritic Cells during Salmonella Pathogenicity Island 1-Independent Salmonella enterica Serovar Typhimurium Infection

(2009) L. Le Bourhis et al.   INFECTION AND IMMUNITY

Nonhematopoietic Cells Control the Outcome of Infection with Listeria monocytogenes in a Nucleotide Oligomerization Domain 1-Dependent Manner

(2009) A. Mosa et al.   INFECTION AND IMMUNITY

Transitions in Oral and Intestinal Microflora Composition and Innate Immune Receptor-Dependent Stimulation during Mouse Development

(2009) M. Hasegawa et al.   INFECTION AND IMMUNITY

pH-dependent Internalization of Muramyl Peptides from Early Endosomes Enables Nod1 and Nod2 Signaling

(2009) Jooeun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Kinase Activity of Rip2 Determines Its Stability and Consequently Nod1- and Nod2-mediated Immune Responses

(2009) Chiara Nembrini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

(2009) S. Lipinski et al.   JOURNAL OF CELL SCIENCE

Defensins and inflammation: The role of defensins in inflammatory bowel disease

(2009) Malith Ramasundara et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Clathrin- and Dynamin-Dependent Endocytic Pathway Regulates Muramyl Dipeptide Internalization and NOD2 Activation

(2009) N. Marina-Garcia et al.   JOURNAL OF IMMUNOLOGY

Helicobacter pylori Induces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism

(2009) C. C. Allison et al.   JOURNAL OF IMMUNOLOGY

Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis

(2009) H. L. Rosenzweig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

(2009) Michael H Shaw et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XIAP mediates NOD signaling via interaction with RIP2

(2009) A. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella Typhimurium Type III Secretion Effectors Stimulate Innate Immune Responses in Cultured Epithelial Cells

(2009) Vincent M. Bruno et al.   PLoS Pathogens

Long-Range Activation of Systemic Immunity through Peptidoglycan Diffusion in Drosophila

(2009) Mathilde Gendrin et al.   PLoS Pathogens

Bacterial Peptide Recognition and Immune Activation Facilitated by Human Peptide TransporterPEPT2

(2008) Peter W. Swaan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pattern recognition receptors and interleukin-8 mediate effects of Gram-positive and Gram-negative bacteria on lung epithelial cell function

(2008) R Sorrentino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Caspase-12 Modulates NOD Signaling and Regulates Antimicrobial Peptide Production and Mucosal Immunity

(2008) Philippe M. LeBlanc et al.   Cell Host & Microbe

Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells

(2008) Julie Bérubé et al.   CELLULAR SIGNALLING

Peptidoglycan and Muropeptides from Pathogens Agrobacterium and Xanthomonas Elicit Plant Innate Immunity: Structure and Activity

(2008) Gitte Erbs et al.   CHEMISTRY & BIOLOGY

MEKK4 Sequesters RIP2 to Dictate NOD2 Signal Specificity

(2008) Nivedita M. Clark et al.   CURRENT BIOLOGY

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

(2008) Osamu Hitotsumatsu et al.   IMMUNITY

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

The Cytosolic Pattern Recognition Receptor NOD1 Induces Inflammatory Interleukin-8 during Chlamydia trachomatis Infection

(2008) K. R. Buchholz et al.   INFECTION AND IMMUNITY

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Autophagic control of listeria through intracellular innate immune recognition in drosophila

(2008) Tamaki Yano et al.   NATURE IMMUNOLOGY

Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis

(2008) Leo A. B. Joosten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA