Article
Oncology
Sigrid P. Dubois, Milos D. Miljkovic, Thomas A. Fleisher, Stefania Pittaluga, Jennifer Hsu-Albert, Bonita R. Bryant, Michael N. Petrus, Liyanage P. Perera, Jurgen R. Muller, Joanna H. Shih, Thomas A. Waldmann, Kevin C. Conlon
Summary: The study demonstrated that administering IL-15 as CIV-5 significantly expanded NK cells with increased cytotoxic functions. There were no dose-limiting toxicities in the CIV-5 regimen, and a substantial increase in CD8(+) T cells was observed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, General & Internal
Frederico J. S. Correa, Marina Paula Andres, Taina Pezzin Rocha, Ana Eduarda Z. Carvalho, Thiago P. A. Aloia, Marcus V. N. Corpa, Esper G. Kallas, Cristovao L. P. Mangueira, Edmund C. Baracat, Karina Carvalho, Mauricio S. Abrao
Summary: The frequencies of iNKT cells and their subsets were evaluated in patients with deep endometriosis. The study found a lower number of iNKT and DN iNKT cells in the blood of endometriosis patients, and an increase in the secretion of IL-17. These findings suggest that iNKT cells may play a role in the pathogenesis of endometriosis.
Article
Oncology
David B. Rosen, Anne Mansson Kvarnhammar, Burkhardt Laufer, Thomas Knappe, Jens Jakob Karlsson, Enping Hong, Yu-Chi Lee, Dhruv Thakar, Luis Alejandro Zuniga, Kathy Bang, Simran Singh Sabharwal, Karan Uppal, Janne Damm Olling, Kristian Kjaergaard, Thomas Kurpiers, Meike Schnabel, Diana Reich, Philipp Glock, Joachim Zettler, Mathias Krusch, Ana Bernhard, Stefan Heinig, Valentino Konjik, Thomas Wegge, Yvonne Hehn, Steffen Killian, Laura Viet, Josefine Runz, Frank Faltinger, Mohammad Tabrizi, Kristin Laura Abel, Vibeke Miller Breinholt, Stina M. Singel, Kennett Sprogoe, Juha Punnonen
Summary: Recombinant interleukin-2 (IL-2) is an approved cancer immunotherapy, but it has severe toxicities and suboptimal pharmacokinetics. TransCon IL-2 beta/gamma is a novel prodrug designed to address these issues, showing sustained release of IL-2 and potential antitumor activity in animal models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Takahiro Uchida, Shuhji Seki, Takashi Oda
Summary: Natural killer T (NKT) cells and NK cells have important roles in antitumor and antimicrobial functions. They are involved in various renal diseases, including acute kidney injury (AKI). NKT cells in mice are activated by specific ligands, cytokines, and bacterial components, leading to AKI. Both renal vascular endothelial cell injury (via perforin-mediated pathway) and tubular epithelial cell injury (via tumor necrosis factor-alpha/Fas ligand pathway) are independently involved in the pathogenesis of AKI. NK cells complement the functions of NKT cells in the development of infection-associated AKI. Human CD56(+) T cells, which are functional counterparts of murine NKT cells, and a subpopulation of CD56(+) NK cells damage intrinsic renal cells in vitro upon activation, possibly through mechanisms similar to those in mice. These cells are also thought to be involved in the acute exacerbation of pre-existing glomerulonephritis triggered by infection in humans, and their roles in sepsis-associated AKI are currently under investigation. In this review, we provide an overview of recent advances in the understanding of the association among infections, NKT and NK cells, and kidney injury, which is much more profound than previously considered. The important role of liver macrophages in the activation of NKT cells is also introduced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Rikang Wang, Weili Bao, Mouli Pal, Yunfeng Liu, Karina Yazdanbakhsh, Hui Zhong
Summary: This study identified the antimetastasis and pro-NK cell activity of IFN-IMo, identified FOXO1 as a key molecule for IFN-gamma driven monocyte differentiation and function, and found NR4A1 as an inhibitory molecule for IFN-IMo activity. It provided potential targets for developing superior monocytic cell therapy against cancer metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz
Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Li Yao, Jianyang Guo, Juan Gui, Feihu Bai, Ruijuan Xin, Yanhong Deng, Shaoxuan Wang, Haitao Li
Summary: The study found dysregulation of ICOS+ Tfr cells in UC patients, which was associated with the severity of UC and could serve as a biomarker of disease progression.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Review
Immunology
Giovanni Monteleone, Eleonora Franze, Edoardo Troncone, Claudia Maresca, Irene Marafini
Summary: Interleukin-34 (IL-34) plays a crucial role in chronic inflammatory bowel diseases (IBD) by promoting interactions between immune cells and stromal cells, leading to increased mucosal inflammation and production of fibrogenic molecules.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sebastien Walchli, Magdalena Winiarska, Radoslaw Zagozdzon
Summary: This study provides new information on the efficacy of PD-L1-targeted CAR against PD-L1(low) targets. The results show that PD-L1-CAR cells have strong reactivity and cytotoxicity against both PD-L1(high) and PD-L1(low) target cells. Additionally, PD-L1-CAR cells also exhibit potent cytotoxic effects against non-malignant cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Constantin Rickassel, Ann-Christin Gnirck, Nikhat Shaikh, Virginia Adamiak, Alex Waterhoelter, Yakup Tanriver, Katrin Neumann, Tobias B. Huber, Georg Gasteiger, Ulf Panzer, Jan-Eric Turner
Summary: In this article, the authors provide a detailed analysis of the NCR+T-bet(+) ILC population in the murine kidney, identifying cNK cells and ILC1s as the two major subsets. The study shows that cNK cells and ILC1s are dispensable for the initiation and progression of immune-mediated glomerular disease. The authors also caution against the use of standard antibody depletion methods for studying NCR+ ILC function in mouse models.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Qi An, Jingwen Zhao, Xueqing Zhu, Baoqi Yang, Zewen Wu, Yazhen Su, Liyun Zhang, Ke Xu, Dan Ma
Summary: This article explores the pathogenesis of Sjogrens syndrome caused by autoantibodies attacking salivary and lacrimal gland tissues, focusing on the role of T cells and therapeutic targeting of T cells for treatment of patients with SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Donghe Li, Yuyin Zhang, Qingsong Qiu, Jinzeng Wang, Xuemei Zhao, Bo Jiao, Xiuli Zhang, Shanhe Yu, Pengfei Xu, Yuqing Dan, Xinhua Xiao, Peihong Wang, Mingzhu Liu, Zhizhou Xia, Zhangsen Huang, Ruihong Zhang, Jiaoyang Li, Xi Xie, Yan Zhang, Chenxuan Liu, Ping Liu, Ruibao Ren
Summary: IRF8 deficiency leads to a decrease in the number of LT-HSCs in mice, but an increase in the repopulation capacity of individual HSCs. The regulation of TLR9 signaling in diverse innate immune cells by IRF8 influences HSCs.
Review
Immunology
Oleksandr Kyrysyuk, Kai W. Wucherpfennig
Summary: T cells and NK cells have complementary roles in tumor immunity. Targeting immune evasion mechanisms and shared receptors between T cells and NK cells can enhance their immune response. Inhibitory and activating cytokines are also potential therapeutic strategies to impact lymphocyte function in tumors.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Review
Oncology
Julian Burks, Purevdorj B. Olkhanud, Jay A. Berzofsky
Summary: Gastrointestinal cancers are a group of complex cancers that affect the digestive system. NKT cells, with their immunoregulatory properties, play a crucial role in tumor immunity and can have either anti-tumor or pro-tumor effects depending on the cytokine profile expressed and the type of GI cancer.
Review
Cell Biology
Ye Xu, Jun Shen, Zhihua Ran
Review
Oncology
Manqing Wu, Jun Shen
FRONTIERS IN ONCOLOGY
(2019)
Review
Gastroenterology & Hepatology
Yueying Chen, Fan Wang, Jun Shen
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Allergy
Chengcen Guo, Jun Shen
Summary: Crohn's disease is a type of inflammatory bowel disease that affects various segments of the gastrointestinal tract. The disruption of intestinal barrier and cell polarity may play a role in the pathogenesis, leading to an inflammatory cascade. Understanding the factors and impact of intestinal barrier function and cell polarity is crucial in the natural history of Crohn's disease.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Ren Mao, Jie Liang, Jun Shen, Subrata Ghosh, Liang-Ru Zhu, Hong Yang, Kai-Chun Wu, Min-Hu Chen
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2020)
Review
Gastroenterology & Hepatology
Ren Mao, Yun Qiu, Jin-Shen He, Jin-Yu Tan, Xue-Hua Li, Jie Liang, Jun Shen, Liang-Ru Zhu, Yan Chen, Marietta Iacucci, Siew C. Ng, Subrata Ghosh, Min-Hu Chen
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Health Care Sciences & Services
Xiaohan Yan, Yuqi Qiao, Jinglu Tong, Ren Mao, Jie Liang, Cuicui Lv, Yueying Chen, Yiyan Wang, Jun Shen
HEALTH AND QUALITY OF LIFE OUTCOMES
(2020)
Article
Gastroenterology & Hepatology
Lijun Xu, Jun Shen, Qing Zheng
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Review
Pharmacology & Pharmacy
Pufang Tan, Xiaogang Li, Jun Shen, Qi Feng
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Immunology
Yiran Yao, Qi Feng, Jun Shen
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2020)
Review
Genetics & Heredity
Yueying Chen, Jun Shen
Summary: Recent studies have highlighted the importance of mucosal immunity in diseases such as respiratory tract infection, inflammatory bowel diseases (IBD), and colorectal cancer (CRC). Transfer RNA (tRNA) and its fragments, including tRNA-derived RNA fragments (tRFs) and tRNA-derived stress-induced RNAs (tiRNAs), have emerged as key players in cellular homeostasis, growth, and apoptosis, but their specific relationship with mucosal immunity remains unclear.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Cell Biology
Xinyi Mao, Jun Shen
Summary: Enteric glial cells play a critical role in regulating gastrointestinal homeostasis and have two-way communication with enteric neurons and immune cells. These interactions may be important in the pathogenesis of Crohn's disease, and abnormalities in glial cells have been found in this disease. However, the specific mechanisms by which enteric glial cells contribute to Crohn's disease need further exploration.
CELL PROLIFERATION
(2023)
Review
Medicine, General & Internal
Yueying Chen, Jun Shen
Summary: The mission of the IBD Quality Care Evaluation Center is to establish a network of IBD quality care units in China and improve the national level of IBD healthcare. Using a Delphi consensus methodology, a list of core and secondary IBD quality care indicators suitable for the Chinese healthcare system was selected, and units meeting the indicators were certified.
Review
Cell Biology
Erpeng Yang, Jun Shen
Summary: Paneth cells play critical roles in controlling gut microbiota and maintaining intestinal homeostasis by secreting alpha-defensins. Inflammatory bowel disease, including Crohn's disease, is closely related to Paneth cells, which are identified as the central element of the pathogenesis.
CELL PROLIFERATION
(2021)
Review
Gastroenterology & Hepatology
Song Su, Jun Shen, Liangru Zhu, Yun Qiu, Jin-Shen He, Jin-Yu Tan, Marietta Iacucci, Siew C. Ng, Subrata Ghosh, Ren Mao, Jie Liang
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2020)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)
