Article
Surgery
Can Lu, Josefine Schardey, Tao Zhang, Alexander Crispin, Ulrich Wirth, Konrad W. Karcz, Alexandr Bazhin, Joachim Andrassy, Jens Werner, Florian Kuehn
Summary: This study conducted a systematic review and meta-analysis to compare the survival outcomes of IBD-associated and non-IBD-associated CRC. The results showed that IBD-CRC patients had a significantly worse overall survival than those without IBD. This may be attributed to more aggressive histological characteristics and a lower rate of R0 resections at the primary tumor site.
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Thais Gagno Grillo, Ana Elisa Valencise Quaglio, Rodrigo Fedatto Beraldo, Talles Bazeia Lima, Julio Pinheiro Baima, Luiz Claudio Di Stasi, Ligia Yukie Sassaki
Summary: miRNAs play a crucial role in regulating gene expression and immune-mediated disorders, particularly in the diagnosis and prognosis of CRC associated with IBD.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Ross J. Porter, Mark J. Arends, Antonia M. D. Churchhouse, Shahida Din
Summary: The cumulative impact of chronic inflammation in patients with inflammatory bowel diseases predisposes to the development of IBD-CRC. Inflammation can induce mutagenesis, and the molecular pathogenesis of IBD-CRC is well described, while the immunopathogenesis is less understood. The impact of novel immunosuppressive therapies on achieving deep remission in IBD-CRC remains mostly unknown.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Jose Maria Huguet, Luis Ferrer-Barcelo, Patricia Suarez, Eva Sanchez, Jose David Prieto, Victor Garcia, Javier Sempere
Summary: The detection of dysplasia in IBD patients is important and chromoendoscopy with targeted biopsy remains the preferred technique. However, other techniques such as virtual chromoendoscopy are being compared due to their similar results and fewer technical difficulties. New endoscopy techniques and improved devices have the potential to revolutionize the screening and follow-up of dysplasia in IBD patients. Further research is needed to define the optimal follow-up strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michelle Temby, Theresa L. Boye, Jacqueline Hoang, Ole H. Nielsen, John Gubatan
Summary: This article reviews the role of kinase signaling pathways in colitis-associated colon cancer, including MAPK, CDK, autophagy-activated kinases, JAK-STAT, and other kinases. It also discusses the involvement of JAK-STAT signaling in the pathogenesis of inflammatory bowel disease (IBD) and the potential use of JAK inhibitors for treating IBD.
Article
Gastroenterology & Hepatology
Rebecca J. Birch, Nicholas Burr, Venkataraman Subramanian, Jim P. Tiernan, Mark A. Hull, Paul Finan, Azmina Rose, Matthew Rutter, Roland Valori, Amy Downing, Eva J. A. Morris
Summary: This study investigated the epidemiology and outcomes of inflammatory bowel disease-associated colorectal cancer (IBD-CRC). It found that IBD patients have a higher risk of developing CRC, are diagnosed at a younger age, and have worse outcomes compared to sporadic CRC. Further research is needed to understand the reasons behind these differences and inform screening, surveillance, and treatment strategies for this high-risk group.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Tawnya M. Hansen, Zoann Nugent, Charles N. Bernstein, N. Jewel Samadder, Sanjay K. Murthy, Harminder Singh
Summary: The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years. There is a high proportion of post colonoscopy CRC among IBD-CRC patients, which has remained unchanged over the years and requires detailed root-cause analysis and interventions.
Article
Gastroenterology & Hepatology
Kristiina Rajamaki, Aurora Taira, Riku Katainen, Niko Valimaki, Anna Kuosmanen, Roosa-Maria Plaketti, Toni T. Seppala, Maarit Ahtiainen, Erkki-Ville Wirta, Emilia Vartiainen, Paivi Sulo, Janne Ravantti, Suvi Lehtipuro, Kirsi J. Granberg, Matti Nykter, Tomas Tanskanen, Ari Ristimaki, Selja Koskensalo, Laura Renkonen-Sinisalo, Anna Lepisto, Jan Bohm, Jussi Taipale, Jukka-Pekka Mecklin, Mervi Aavikko, Kimmo Palin, Lauri A. Aaltonen
Summary: By comprehensively characterizing IBD-associated tumorigenesis using multiple high-throughput approaches, distinct mechanisms of WNT pathway dysregulation were identified in IBD-CRC, which skew the tumors towards a mesenchymal subtype. Additionally, epigenetic modifications and noncoding mutations in specific genes were found in IBD-CRC, highlighting further differences compared to sCRC.
Article
Gastroenterology & Hepatology
Estefania Flores, Chimezie Mbachi, Ikechukwu Achebe, Jennifer Asotibe, Emmanuel Palomera-Tejeda, Ishaan Vohra, Victor Udechukwu, Vikram Kotwal
Summary: While mortality trends in non-IBD-CRC population have significantly decreased, there is no significant trend in mortality for IBD-CRC population. Further strategies are needed to reduce IBD-CRC mortality trends.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Endocrinology & Metabolism
Yuxuan Xia, Li Zhang, Dickson Kofi Wiredu Ocansey, Qiang Tu, Fei Mao, Xiumei Sheng
Summary: Inflammatory bowel disease (IBD) and colorectal cancer (CRC) share a common factor in their development, glycolysis, which affects various aspects of gastrointestinal tissues. In IBD, glycolysis impacts the intestinal microbiota, mucosal barrier function, and the immune system, while in CRC, it is linked to multiple signaling pathways and transcription factors. A comprehensive study of glycolysis is crucial for a better understanding of the pathogenesis and therapeutic targets of both IBD and CRC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Gastroenterology & Hepatology
Massimo Claudio Fantini, Ilaria Guadagni
Summary: Patients with UC and CD have an increased risk of developing CRC, with inflammation playing a crucial role in the pathogenesis of CAC. Control of inflammation is pivotal to the prevention of CAC.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Medicine, General & Internal
Naim Abu-Freha, Bracha Cohen, Michal Gordon, Sarah Weissmann, Emily H. Kestenbaum, Sergei Vosko, Muhammad Abu-Tailakh, Liza Ben-Shoshan, Daniel L. Cohen, Haim Shirin
Summary: This study investigated the prevalence and risk factors of CRC among a large cohort of IBD patients. The results showed that the rate of CRC was higher in CD and UC patients compared to the general population. Age, primary sclerosing cholangitis, diabetes mellitus, and glucocorticoids treatment were found to be predictors of CRC. Therefore, IBD patients, especially those with risk factors, should be closely monitored for CRC.
FRONTIERS IN MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Jordan E. Axelrad, Raymond K. Cross
Summary: Patients with chronic ulcerative and Crohn's colitis have a higher risk of developing colorectal neoplasia (CRN [dysplasia and cancer]) compared to the general population. Risk factors for CRN include the extent of colitis, cumulative inflammatory burden, family history of colorectal cancer, and primary sclerosing cholangitis. Best practices for preventing CRN involve controlling colonic inflammation, conducting high quality surveillance colonoscopy with or without enhanced imaging techniques, removing visible dysplasia if possible, and considering colectomy for patients with unresectable dysplasia, invisible multifocal low-grade dysplasia, or invisible high-grade dysplasia. The decision to stop dysplasia surveillance should be individualized and based on factors such as age, frailty, comorbid conditions, life expectancy, previous surveillance exam results, and risk factors for CRN.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Benedetto Neri, Maria Lia Scribano, Alessandro Armuzzi, Fabiana Castiglione, Renata D'Inca, Ambrogio Orlando, Stefano Festa, Gabriele Riegler, Walter Fries, Gianmichele Meucci, Patrizia Alvisi, Filippo Mocciaro, Claudio Papi, Michelangela Mossa, Giorgia Sena, Luisa Guidi, Anna Testa, Sara Renna, Iris Frankovic, Anna Viola, Marta Patturelli, Carlo Chiaramonte, Livia Biancone
Summary: The sequence chronic inflammation-dysplasia-cancer is involved in the development of several gastrointestinal cancers. The characteristics of IBD, including CRC-related symptoms at onset, play a role in the long-term outcome of CRC in IBD patients. CRC has a higher incidence in UC and CD patients. Surveillance programs should focus on high-risk subgroups of patients.
