Selective class IIa HDAC inhibitors: myth or reality

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Improved Synthesis and Structural Reassignment of MC1568: A Class IIa Selective HDAC Inhibitor

(2014) Cassandra L. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDAC4: mechanism of regulation and biological functions

(2014) Zhengke Wang et al.   Epigenomics

Towards Selective Inhibition of Histone Deacetylase Isoforms: What Has Been Achieved, Where We Are and What Will Be Next

(2013) Florian Thaler et al.   ChemMedChem

Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases

(2013) Frank J. Dekker et al.   DRUG DISCOVERY TODAY

Class IIa Histone Deacetylases and Myocyte Enhancer Factor 2 Proteins Regulate the Mesenchymal-to-Epithelial Transition of Somatic Cell Reprogramming

(2013) Qiang Zhuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC4 controls histone methylation in response to elevated cardiac load

(2013) Mathias Hohl et al.   JOURNAL OF CLINICAL INVESTIGATION

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease

(2013) Roland W. Bürli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes

(2013) Naoko Hara et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

MEF2 Is a Converging Hub for Histone Deacetylase 4 and Phosphatidylinositol 3-Kinase/Akt-Induced Transformation

(2013) Eros Di Giorgio et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group

(2013) Mercedes Lobera et al.   Nature Chemical Biology

Histone acetylation: molecular mnemonics on the chromatin

(2013) Johannes Gräff et al.   NATURE REVIEWS NEUROSCIENCE

HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin

(2013) Ozan Aygün et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identifying targets for the restoration and reactivation of BRM

(2013) B Kahali et al.   ONCOGENE

HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses

(2013) J E Bolden et al.   Cell Death & Disease

Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment

(2012) J. T. Isaacs et al.   CANCER RESEARCH

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Beside the MEF2 axis: Unconventional functions of HDAC4

(2012) Andrea Clocchiatti et al.   CELLULAR SIGNALLING

Class IIa HDACs repressive activities on MEF2-depedent transcription are associated with poor prognosis of ER+ breast tumors

(2012) Andrea Clocchiatti et al.   FASEB JOURNAL

Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives

(2012) Giuseppe Giannini et al.   Future Medicinal Chemistry

Histone Deacetylase (HDAC) Inhibitors with a Novel Connecting Unit Linker Region Reveal a Selectivity Profile for HDAC4 and HDAC5 with Improved Activity against Chemoresistant Cancer Cells

(2012) Linda Marek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells

(2012) Suryaprakash Raichur et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A Direct HDAC4-MAP Kinase Crosstalk Activates Muscle Atrophy Program

(2012) Moon-Chang Choi et al.   MOLECULAR CELL

The role of histone demethylases in cancer therapy

(2012) Inga Hoffmann et al.   Molecular Oncology

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

(2012) Jiali Li et al.   NATURE MEDICINE

Regulated Shuttling of the Histone Deacetylase HDAC5 to the Nucleus May Put a Brake on Cocaine Addiction

(2012) Anne E. West   NEURON

Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2

(2012) Nimanthi Jayathilaka et al.   NUCLEIC ACIDS RESEARCH

Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells

(2012) I. Venza et al.   Pigment Cell & Melanoma Research

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

(2012) N. Gammoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases

(2011) Leonhard M. Henkes et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

Epigenetic aberrations during oncogenesis

(2011) Maria Hatziapostolou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins

(2011) Izhak Kehat et al.   JOURNAL OF CELL BIOLOGY

Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis

(2011) Andrea Clocchiatti et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor

(2011) Y. Kong et al.   MOLECULAR CANCER THERAPEUTICS

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

(2011) Raffaella Di Micco et al.   NATURE CELL BIOLOGY

Tasquinimod prevents the angiogenic rebound induced by fractionated radiation resulting in an enhanced therapeutic response of prostate cancer xenografts

(2011) Susan L. Dalrymple et al.   PROSTATE

Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases

(2010) Viviana Moresi et al.   CELL

Inside HDAC with HDAC inhibitors

(2010) Philippe Bertrand   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Class II Histone Deacetylases Limit GLUT4 Gene Expression during Adipocyte Differentiation

(2010) Juston Weems et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation

(2010) Angela Nebbioso et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors

(2010) Anders Olsson et al.   Molecular Cancer

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

(2010) R. Rad et al.   SCIENCE

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors

(2009) Pierre Tessier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells

(2009) Young-Sook Baek et al.   BMC IMMUNOLOGY

Isoform-specific histone deacetylase inhibitors: The next step?

(2009) Sriram Balasubramanian et al.   CANCER LETTERS

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Clinical Studies of Histone Deacetylase Inhibitors

(2009) H. M. Prince et al.   CLINICAL CANCER RESEARCH

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes

(2009) Angela Nebbioso et al.   EMBO REPORTS

Inhibition of HDAC9 Increases T Regulatory Cell Function and Prevents Colitis in Mice

(2009) Edwin F. de Zoeten et al.   GASTROENTEROLOGY

Histone Deacetylase Inhibitors in Cancer Therapy

(2009) Andrew A. Lane et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy

(2009) Jesus M. Ontoria et al.   JOURNAL OF MEDICINAL CHEMISTRY

2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors

(2008) Philip Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

(2008) Philip Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

(2008) Tetsuro Ago et al.   CELL

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

(2008) S. L. McGee et al.   DIABETES

The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity

(2008) Todd J. Cohen et al.   FASEB JOURNAL

GLUT4 Enhancer Factor (GEF) Interacts with MEF2A and HDAC5 to Regulate theGLUT4Promoter in Adipocytes

(2008) David P. Sparling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

(2008) Matthew J. Bottomley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

(2008) Anja Schuetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

(2008) Andrew J. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL

Specific Activity of Class II Histone Deacetylases in Human Breast Cancer Cells

(2008) V. Duong et al.   MOLECULAR CANCER RESEARCH

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

(2008) D Mottet et al.   ONCOGENE