Ionic mechanisms in pancreatic β cell signaling

Pancreatic β-cell Na+ channels control global Ca2+ signaling and oxidative metabolism by inducing Na+ and Ca2+ responses that are propagated into mitochondria

(2014) Iulia I. Nita et al.   FASEB JOURNAL

L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function

(2014) Franz Hofmann et al.   PHYSIOLOGICAL REVIEWS

Voltage-gated calcium channels function as Ca2+-activated signaling receptors

(2014) Daphne Atlas   TRENDS IN BIOCHEMICAL SCIENCES

The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src

(2013) Yue Shi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transient Receptor Potential (TRP) Cation Channels in Diabetes

(2013) Barbara Colsoul et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery

(2013) Sandrine Poëa-Guyon et al.   JOURNAL OF CELL BIOLOGY

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

KATP channels and islet hormone secretion: new insights and controversies

(2013) Frances M. Ashcroft et al.   Nature Reviews Endocrinology

Purinergic signalling in endocrine organs

(2013) Geoffrey Burnstock   Purinergic Signalling

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

The diabetic β-cell: hyperstimulated vs. hyperexcited

(2012) C. G. Nichols et al.   DIABETES OBESITY & METABOLISM

Ryanodine Receptors: Structure and Function

(2012) Filip Van Petegem   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-gated potassium channels and the diversity of electrical signalling

(2012) Lily Yeh Jan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells

(2012) De-Shou Cao et al.   PLoS One

Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron

(2012) Shao-Nian Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

(2012) E. Tringham et al.   Science Translational Medicine

Regulation of calcium in pancreatic α- and β-cells in health and disease

(2011) Patrik Rorsman et al.   CELL CALCIUM

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

(2011) J. N. Walker et al.   DIABETES OBESITY & METABOLISM

Cholesterol Elevation Impairs Glucose-Stimulated Ca2+Signaling in Mouse Pancreatic β-Cells

(2011) Andy K. Lee et al.   ENDOCRINOLOGY

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

(2011) Ben Montpetit et al.   NATURE

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes

(2011) N. Soltani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lowering apolipoprotein CIII delays onset of type 1 diabetes

(2011) R. Holmberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans

(2011) Patrik Rorsman et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Voltage-Gated Calcium Channels

(2011) W. A. Catterall   Cold Spring Harbor Perspectives in Biology

Mitochondrial proteome analysis reveals altered expression of voltage dependent anion channels in pancreatic β-cells exposed to high glucose

(2011) Meftun Ahmed et al.   Islets

Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells

(2010) Kyota Aoyagi et al.   BIOCHEMICAL JOURNAL

 -Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic  -Cells

(2010) M. Braun et al.   DIABETES

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice

(2010) K. Uchida et al.   DIABETES

Identification of Direct and Indirect Effectors of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel

(2010) Balázs Tóth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses

(2010) David A. Jacobson et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells

(2010) Thomas F. J. Wagner et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPM5 regulates glucose-stimulated insulin secretion

(2010) Lili R. Brixel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

(2010) B. Colsoul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrical activity in pancreatic islet cells: The VRAC hypothesis

(2010) Leonard Best et al.   Islets

Suppression of Sulfonylurea- and Glucose-Induced Insulin Secretion In Vitro and In Vivo in Mice Lacking the Chloride Transport Protein ClC-3

(2009) Dai-Qing Li et al.   Cell Metabolism

The Granular Chloride Channel ClC-3 Is Permissive for Insulin Secretion

(2009) Ludmila V. Deriy et al.   Cell Metabolism

Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic  -Cells

(2009) M. Dufer et al.   DIABETES

Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic β cells

(2009) Yi Zhang et al.   JOURNAL OF ENDOCRINOLOGY

Chloride channels as drug targets

(2009) Alan S. Verkman et al.   NATURE REVIEWS DRUG DISCOVERY

Electrophysiological and Immunocytochemical Evidence for P2X Purinergic Receptors in Pancreatic β Cells

(2009) Amélia M. Silva et al.   PANCREAS

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in   Cells

(2009) I. Lange et al.   Science Signaling

Single Particle Image Reconstruction of the Human Recombinant Kv2.1 Channel

(2008) Brian Adair et al.   BIOPHYSICAL JOURNAL

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4

(2008) S. Casas et al.   DIABETOLOGIA

Inhibition of Cholesterol Biosynthesis Impairs Insulin Secretion and Voltage-Gated Calcium Channel Function in Pancreatic β-Cells

(2008) Fuzhen Xia et al.   ENDOCRINOLOGY

Interdomain Cytoplasmic Interactions Govern the Intracellular Trafficking, Gating, and Modulation of the Kv2.1 Channel

(2008) D. P. Mohapatra et al.   JOURNAL OF NEUROSCIENCE

Novel aspects of the molecular mechanisms controlling insulin secretion

(2008) Lena Eliasson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

(2008) Thomas F.J. Wagner et al.   NATURE CELL BIOLOGY

Noninvasive in vivo imaging of pancreatic islet cell biology

(2008) Stephan Speier et al.   NATURE MEDICINE

Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye

(2008) Stephan Speier et al.   Nature Protocols

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2β in pancreatic β-cells and in iPLA2β-null mice

(2007) Shunzhong Bao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM